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Gene: KIAA2013 |
Gene summary for KIAA2013 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | KIAA2013 | Gene ID | 90231 |
| Gene name | KIAA2013 | |
| Gene Alias | KIAA2013 | |
| Cytomap | 1p36.22 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8IYS2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 90231 | KIAA2013 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.02e-18 | 7.44e-01 | -0.1808 |
| 90231 | KIAA2013 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.23e-06 | 4.27e-01 | -0.0811 |
| 90231 | KIAA2013 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.79e-04 | 3.05e-01 | -0.1088 |
| 90231 | KIAA2013 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.49e-29 | 7.20e-01 | -0.1954 |
| 90231 | KIAA2013 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.10e-03 | 6.83e-01 | -0.2602 |
| 90231 | KIAA2013 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.72e-03 | 4.41e-01 | -0.2196 |
| 90231 | KIAA2013 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.12e-12 | 6.01e-01 | -0.1207 |
| 90231 | KIAA2013 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.90e-10 | 4.46e-01 | -0.1526 |
| 90231 | KIAA2013 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.59e-20 | 6.89e-01 | -0.1464 |
| 90231 | KIAA2013 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.69e-13 | 4.74e-01 | -0.1001 |
| 90231 | KIAA2013 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.92e-15 | 6.19e-01 | -0.059 |
| 90231 | KIAA2013 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.87e-04 | 4.86e-01 | -0.1706 |
| 90231 | KIAA2013 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.33e-03 | 3.60e-01 | -0.2061 |
| 90231 | KIAA2013 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.44e-03 | 3.87e-01 | -0.0842 |
| 90231 | KIAA2013 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.89e-11 | 5.89e-01 | -0.0179 |
| 90231 | KIAA2013 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.16e-21 | 6.07e-01 | 0.096 |
| 90231 | KIAA2013 | HTA11_8622_2000001021 | Human | Colorectum | SER | 9.92e-05 | 4.91e-01 | 0.0528 |
| 90231 | KIAA2013 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.93e-05 | 6.06e-01 | 0.0131 |
| 90231 | KIAA2013 | HTA11_10623_2000001011 | Human | Colorectum | AD | 5.37e-08 | 6.41e-01 | -0.0177 |
| 90231 | KIAA2013 | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.98e-08 | 7.05e-01 | 0.0171 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| KIAA2013 | SNV | Missense_Mutation | novel | c.1586A>G | p.Asp529Gly | p.D529G | Q8IYS2 | protein_coding | deleterious(0.02) | benign(0.03) | TCGA-A2-A1FW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
| KIAA2013 | SNV | Missense_Mutation | novel | c.1156G>A | p.Glu386Lys | p.E386K | Q8IYS2 | protein_coding | tolerated(0.24) | benign(0.077) | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| KIAA2013 | SNV | Missense_Mutation | c.1739N>G | p.Asp580Gly | p.D580G | Q8IYS2 | protein_coding | deleterious(0.01) | benign(0.396) | TCGA-AQ-A1H3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
| KIAA2013 | SNV | Missense_Mutation | c.1741G>A | p.Glu581Lys | p.E581K | Q8IYS2 | protein_coding | deleterious(0.01) | possibly_damaging(0.803) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| KIAA2013 | SNV | Missense_Mutation | c.1426N>A | p.Val476Met | p.V476M | Q8IYS2 | protein_coding | deleterious(0.03) | probably_damaging(0.994) | TCGA-C5-A2LV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| KIAA2013 | insertion | Frame_Shift_Ins | novel | c.1609_1610insAGGACAGC | p.Ala537GlufsTer14 | p.A537Efs*14 | Q8IYS2 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
| KIAA2013 | SNV | Missense_Mutation | c.1426N>A | p.Val476Met | p.V476M | Q8IYS2 | protein_coding | deleterious(0.03) | probably_damaging(0.994) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| KIAA2013 | SNV | Missense_Mutation | c.1751N>T | p.Ala584Val | p.A584V | Q8IYS2 | protein_coding | deleterious(0.01) | possibly_damaging(0.698) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| KIAA2013 | SNV | Missense_Mutation | rs761268626 | c.1423G>A | p.Asp475Asn | p.D475N | Q8IYS2 | protein_coding | tolerated(0.09) | benign(0.041) | TCGA-QG-A5YW-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | CR |
| KIAA2013 | SNV | Missense_Mutation | novel | c.1736N>G | p.His579Arg | p.H579R | Q8IYS2 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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