Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: KIAA1841

Gene summary for KIAA1841

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

KIAA1841

Gene ID

84542

Gene nameSANT and BTB domain regulator of CSR
Gene AliasKIAA1841
Cytomap2p15
Gene Typeprotein-coding
GO ID

NA

UniProtAcc

Q6NSI8


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
84542KIAA1841CCI_1HumanCervixCC2.54e-085.52e-010.528
84542KIAA1841CCI_2HumanCervixCC3.06e-085.60e-010.5249
84542KIAA1841CCI_3HumanCervixCC2.95e-095.33e-010.516
84542KIAA1841sample3HumanCervixCC1.19e-072.86e-010.1387
84542KIAA1841T3HumanCervixCC2.76e-062.85e-010.1389
84542KIAA1841HCC2_MengHumanLiverHCC1.11e-026.36e-020.0107
84542KIAA1841HCC1HumanLiverHCC3.09e-113.47e+000.5336
84542KIAA1841HCC2HumanLiverHCC1.05e-132.89e+000.5341
84542KIAA1841S015HumanLiverHCC1.44e-042.85e-010.2375
84542KIAA1841S028HumanLiverHCC3.02e-052.71e-010.2503
84542KIAA1841S029HumanLiverHCC2.08e-022.21e-010.2581
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
KIAA1841SNVMissense_Mutationc.94N>Gp.Gln32Glup.Q32EQ6NSI8protein_codingtolerated(0.12)benign(0.003)TCGA-A2-A0CX-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
KIAA1841SNVMissense_Mutationnovelc.1823N>Gp.Lys608Argp.K608RQ6NSI8protein_codingtolerated(0.08)benign(0.039)TCGA-A2-A0T0-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereSD
KIAA1841SNVMissense_Mutationrs376731071c.842N>Tp.Ser281Leup.S281LQ6NSI8protein_codingdeleterious(0.01)benign(0.047)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
KIAA1841SNVMissense_Mutationc.883N>Gp.Phe295Valp.F295VQ6NSI8protein_codingtolerated(0.09)benign(0.094)TCGA-FU-A3HZ-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
KIAA1841SNVMissense_Mutationnovelc.1693N>Cp.Glu565Glnp.E565QQ6NSI8protein_codingdeleterious(0.01)probably_damaging(0.971)TCGA-ZJ-AAXU-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
KIAA1841SNVMissense_Mutationrs756138624c.500N>Tp.Asp167Valp.D167VQ6NSI8protein_codingdeleterious(0)probably_damaging(0.993)TCGA-A6-3809-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
KIAA1841SNVMissense_Mutationc.1027C>Tp.Pro343Serp.P343SQ6NSI8protein_codingtolerated(0.4)benign(0.011)TCGA-AA-3510-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
KIAA1841SNVMissense_Mutationnovelc.214T>Cp.Ser72Prop.S72PQ6NSI8protein_codingtolerated(1)benign(0)TCGA-AA-3845-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
KIAA1841SNVMissense_Mutationnovelc.694N>Ap.Leu232Ilep.L232IQ6NSI8protein_codingdeleterious(0.03)probably_damaging(0.999)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
KIAA1841SNVMissense_Mutationc.1339N>Tp.Arg447Trpp.R447WQ6NSI8protein_codingdeleterious(0)probably_damaging(0.995)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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