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Gene: KIAA1551 |
Gene summary for KIAA1551 |
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Gene information | Species | Human | Gene symbol | KIAA1551 | Gene ID | 55196 |
Gene name | retroelement silencing factor 1 | |
Gene Alias | C12orf35 | |
Cytomap | 12p11.21 | |
Gene Type | protein-coding | GO ID | GO:0006325 | UniProtAcc | Q9HCM1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55196 | KIAA1551 | AEH-subject1 | Human | Endometrium | AEH | 7.83e-39 | -6.13e-01 | -0.3059 |
55196 | KIAA1551 | AEH-subject2 | Human | Endometrium | AEH | 1.83e-30 | -6.13e-01 | -0.2525 |
55196 | KIAA1551 | AEH-subject3 | Human | Endometrium | AEH | 1.16e-34 | -6.13e-01 | -0.2576 |
55196 | KIAA1551 | AEH-subject4 | Human | Endometrium | AEH | 1.29e-23 | -6.13e-01 | -0.2657 |
55196 | KIAA1551 | AEH-subject5 | Human | Endometrium | AEH | 1.16e-34 | -6.13e-01 | -0.2953 |
55196 | KIAA1551 | EEC-subject1 | Human | Endometrium | EEC | 5.49e-38 | -6.13e-01 | -0.2682 |
55196 | KIAA1551 | EEC-subject2 | Human | Endometrium | EEC | 3.80e-37 | -6.13e-01 | -0.2607 |
55196 | KIAA1551 | EEC-subject3 | Human | Endometrium | EEC | 2.94e-39 | -6.13e-01 | -0.2525 |
55196 | KIAA1551 | EEC-subject4 | Human | Endometrium | EEC | 3.80e-37 | -6.13e-01 | -0.2571 |
55196 | KIAA1551 | EEC-subject5 | Human | Endometrium | EEC | 5.49e-38 | -6.13e-01 | -0.249 |
55196 | KIAA1551 | GSM5276934 | Human | Endometrium | EEC | 2.76e-07 | -3.81e-01 | -0.0913 |
55196 | KIAA1551 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.34e-09 | -3.62e-02 | -0.1869 |
55196 | KIAA1551 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 5.65e-12 | 4.10e-02 | -0.1875 |
55196 | KIAA1551 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 5.43e-15 | 9.36e-02 | -0.1883 |
55196 | KIAA1551 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 8.44e-07 | -1.20e-01 | -0.1934 |
55196 | KIAA1551 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.87e-18 | 1.15e-01 | -0.1917 |
55196 | KIAA1551 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.96e-20 | 1.04e-01 | -0.1916 |
55196 | KIAA1551 | P2T-E | Human | Esophagus | ESCC | 2.16e-23 | 4.85e-01 | 0.1177 |
55196 | KIAA1551 | P4T-E | Human | Esophagus | ESCC | 3.92e-18 | 3.88e-01 | 0.1323 |
55196 | KIAA1551 | P5T-E | Human | Esophagus | ESCC | 4.19e-12 | 1.45e-02 | 0.1327 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA1551 | SNV | Missense_Mutation | novel | c.2311N>T | p.Val771Phe | p.V771F | Q9HCM1 | protein_coding | deleterious(0) | possibly_damaging(0.839) | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
KIAA1551 | SNV | Missense_Mutation | c.3118N>A | p.Glu1040Lys | p.E1040K | Q9HCM1 | protein_coding | tolerated(0.12) | possibly_damaging(0.791) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KIAA1551 | SNV | Missense_Mutation | novel | c.5055N>T | p.Lys1685Asn | p.K1685N | Q9HCM1 | protein_coding | deleterious(0.02) | possibly_damaging(0.814) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA1551 | SNV | Missense_Mutation | c.4246G>A | p.Glu1416Lys | p.E1416K | Q9HCM1 | protein_coding | deleterious(0) | possibly_damaging(0.754) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
KIAA1551 | SNV | Missense_Mutation | c.191T>C | p.Leu64Pro | p.L64P | Q9HCM1 | protein_coding | tolerated(0.18) | benign(0.025) | TCGA-E2-A1BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
KIAA1551 | SNV | Missense_Mutation | novel | c.4394A>G | p.Lys1465Arg | p.K1465R | Q9HCM1 | protein_coding | tolerated(0.08) | benign(0.13) | TCGA-E9-A1R6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
KIAA1551 | SNV | Missense_Mutation | c.3439T>C | p.Cys1147Arg | p.C1147R | Q9HCM1 | protein_coding | tolerated(0.05) | possibly_damaging(0.592) | TCGA-E9-A1RG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
KIAA1551 | SNV | Missense_Mutation | novel | c.5216N>T | p.Arg1739Ile | p.R1739I | Q9HCM1 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-EW-A6S9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA1551 | SNV | Missense_Mutation | c.3286N>A | p.Asp1096Asn | p.D1096N | Q9HCM1 | protein_coding | deleterious(0.05) | benign(0.234) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
KIAA1551 | insertion | Frame_Shift_Ins | novel | c.3704_3705insTC | p.Asn1236GlnfsTer40 | p.N1236Qfs*40 | Q9HCM1 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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