Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: KIAA1549

Gene summary for KIAA1549

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

KIAA1549

Gene ID

57670

Gene nameKIAA1549
Gene AliasRP86
Cytomap7q34
Gene Typeprotein-coding
GO ID

GO:0005575

UniProtAcc

Q9HCM3


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
57670KIAA1549HCC1_MengHumanLiverHCC1.53e-174.38e-020.0246
57670KIAA1549HCC1HumanLiverHCC6.66e-051.97e+000.5336
57670KIAA1549HCC2HumanLiverHCC1.86e-081.05e+000.5341
57670KIAA1549HCC5HumanLiverHCC1.27e-045.05e-010.4932
57670KIAA1549S027HumanLiverHCC1.34e-073.49e-010.2446
57670KIAA1549S028HumanLiverHCC1.70e-092.56e-010.2503
57670KIAA1549S029HumanLiverHCC2.88e-022.01e-010.2581
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
KIAA1549SNVMissense_Mutationnovelc.4108N>Tp.Ile1370Phep.I1370FQ9HCM3protein_codingdeleterious(0)probably_damaging(0.99)TCGA-5L-AAT0-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
KIAA1549SNVMissense_Mutationnovelc.5734N>Gp.Thr1912Alap.T1912AQ9HCM3protein_codingtolerated(0.1)benign(0.006)TCGA-A2-A0D1-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapytaxotereSD
KIAA1549SNVMissense_Mutationnovelc.2641N>Gp.Thr881Alap.T881AQ9HCM3protein_codingtolerated(0.29)benign(0)TCGA-A2-A3Y0-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
KIAA1549SNVMissense_Mutationnovelc.3483N>Ap.Asn1161Lysp.N1161KQ9HCM3protein_codingdeleterious(0)probably_damaging(0.993)TCGA-A7-A6VY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideCR
KIAA1549SNVMissense_Mutationc.3831A>Tp.Gln1277Hisp.Q1277HQ9HCM3protein_codingdeleterious(0.04)benign(0.437)TCGA-A8-A08L-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
KIAA1549SNVMissense_Mutationc.208N>Gp.His70Aspp.H70DQ9HCM3protein_codingdeleterious_low_confidence(0)benign(0.08)TCGA-AN-A0FX-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
KIAA1549SNVMissense_Mutationrs777901817c.1757C>Tp.Pro586Leup.P586LQ9HCM3protein_codingdeleterious(0.05)benign(0.085)TCGA-AR-A0U2-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapytamoxiphenPD
KIAA1549SNVMissense_Mutationnovelc.548N>Tp.Pro183Leup.P183LQ9HCM3protein_codingtolerated(1)benign(0)TCGA-BH-A8FY-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KIAA1549SNVMissense_Mutationc.3244N>Tp.His1082Tyrp.H1082YQ9HCM3protein_codingdeleterious(0.02)benign(0.158)TCGA-C8-A26Z-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenCR
KIAA1549insertionFrame_Shift_Insnovelc.5735_5736insATTCTTCCTCCTTCTTCTGGTGCTAp.Ser1913PhefsTer114p.S1913Ffs*114Q9HCM3protein_codingTCGA-A2-A0D1-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapytaxotereSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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