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Gene: KIAA1468 |
Gene summary for KIAA1468 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | KIAA1468 | Gene ID | 57614 |
| Gene name | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing | |
| Gene Alias | HsT3308 | |
| Cytomap | 18q21.33 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9P260 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57614 | KIAA1468 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.39e-48 | -9.55e-01 | 0.0155 |
| 57614 | KIAA1468 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.48e-30 | -9.55e-01 | -0.1808 |
| 57614 | KIAA1468 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.73e-08 | -9.55e-01 | 0.0216 |
| 57614 | KIAA1468 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.86e-24 | -9.55e-01 | -0.0811 |
| 57614 | KIAA1468 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.24e-35 | -9.55e-01 | -0.1088 |
| 57614 | KIAA1468 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.96e-52 | -9.55e-01 | -0.1954 |
| 57614 | KIAA1468 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.42e-05 | -9.55e-01 | -0.2602 |
| 57614 | KIAA1468 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.92e-07 | -9.55e-01 | -0.2196 |
| 57614 | KIAA1468 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.38e-24 | -9.55e-01 | -0.1207 |
| 57614 | KIAA1468 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.11e-20 | -9.55e-01 | -0.1526 |
| 57614 | KIAA1468 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.20e-61 | -9.55e-01 | -0.1464 |
| 57614 | KIAA1468 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.40e-57 | -9.55e-01 | -0.1001 |
| 57614 | KIAA1468 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.56e-40 | -9.55e-01 | -0.059 |
| 57614 | KIAA1468 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.60e-10 | -9.55e-01 | -0.1706 |
| 57614 | KIAA1468 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.27e-12 | -9.55e-01 | -0.2061 |
| 57614 | KIAA1468 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.73e-08 | -9.55e-01 | -0.1462 |
| 57614 | KIAA1468 | HTA11_546_2000001011 | Human | Colorectum | AD | 7.86e-18 | -9.55e-01 | -0.0842 |
| 57614 | KIAA1468 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.42e-05 | -9.55e-01 | -0.00410000000000005 |
| 57614 | KIAA1468 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.21e-15 | -9.55e-01 | -0.0179 |
| 57614 | KIAA1468 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.12e-43 | -9.55e-01 | 0.096 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| KIAA1468 | SNV | Missense_Mutation | novel | c.2541N>G | p.Ile847Met | p.I847M | Q9P260 | protein_coding | tolerated(0.16) | possibly_damaging(0.474) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| KIAA1468 | SNV | Missense_Mutation | novel | c.2852N>A | p.Ser951Tyr | p.S951Y | Q9P260 | protein_coding | deleterious(0) | possibly_damaging(0.506) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| KIAA1468 | SNV | Missense_Mutation | c.3061N>C | p.Ile1021Leu | p.I1021L | Q9P260 | protein_coding | deleterious(0.01) | benign(0.204) | TCGA-E2-A14Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
| KIAA1468 | SNV | Missense_Mutation | c.640N>T | p.Ala214Ser | p.A214S | Q9P260 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-E9-A1NE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
| KIAA1468 | deletion | Frame_Shift_Del | novel | c.2411delN | p.Arg804LeufsTer15 | p.R804Lfs*15 | Q9P260 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| KIAA1468 | deletion | Frame_Shift_Del | novel | c.2189delN | p.Lys731AsnfsTer25 | p.K731Nfs*25 | Q9P260 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
| KIAA1468 | SNV | Missense_Mutation | c.2265G>C | p.Leu755Phe | p.L755F | Q9P260 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| KIAA1468 | SNV | Missense_Mutation | novel | c.3040G>A | p.Asp1014Asn | p.D1014N | Q9P260 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| KIAA1468 | insertion | Frame_Shift_Ins | novel | c.278_279insCTGTCAGG | p.Ile94CysfsTer18 | p.I94Cfs*18 | Q9P260 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
| KIAA1468 | SNV | Missense_Mutation | c.3019N>A | p.Ala1007Thr | p.A1007T | Q9P260 | protein_coding | deleterious(0) | possibly_damaging(0.849) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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