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Gene: KIAA1244 |
Gene summary for KIAA1244 |
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Gene information | Species | Human | Gene symbol | KIAA1244 | Gene ID | 57221 |
Gene name | ARFGEF family member 3 | |
Gene Alias | A7322 | |
Cytomap | 6q23.3-q24.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q5TH69 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57221 | KIAA1244 | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 2.22e-03 | 5.29e-01 | 0.1531 |
57221 | KIAA1244 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 9.88e-13 | 4.76e-01 | 0.1633 |
57221 | KIAA1244 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 1.37e-13 | 4.91e-01 | 0.1608 |
57221 | KIAA1244 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 1.63e-12 | 5.86e-01 | 0.1604 |
57221 | KIAA1244 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 4.44e-11 | 4.47e-01 | 0.1621 |
57221 | KIAA1244 | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 3.50e-02 | 3.61e-01 | 0.1619 |
57221 | KIAA1244 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 1.56e-05 | 3.73e-01 | 0.1602 |
57221 | KIAA1244 | GSM5353232_PA_PR5249_T1_S3_L001 | Human | Prostate | Tumor | 3.03e-02 | 5.68e-01 | 0.1439 |
57221 | KIAA1244 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 8.40e-07 | 3.13e-01 | 0.1575 |
57221 | KIAA1244 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 1.82e-05 | 3.26e-01 | 0.1569 |
57221 | KIAA1244 | GSM5353247_PA_PR5269_3_S27_L002 | Human | Prostate | Tumor | 1.33e-04 | 9.17e-01 | 0.1532 |
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Tissue | Expression Dynamics | Abbreviation |
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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