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Gene: KIAA1211L |
Gene summary for KIAA1211L |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | KIAA1211L | Gene ID | 343990 |
| Gene name | CRACD like | |
| Gene Alias | C2orf55 | |
| Cytomap | 2q11.2 | |
| Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q6NV74 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 343990 | KIAA1211L | C43 | Human | Oral cavity | OSCC | 1.18e-32 | 6.50e-01 | 0.1704 |
| 343990 | KIAA1211L | C46 | Human | Oral cavity | OSCC | 2.51e-32 | 7.33e-01 | 0.1673 |
| 343990 | KIAA1211L | C57 | Human | Oral cavity | OSCC | 1.18e-04 | 2.78e-01 | 0.1679 |
| 343990 | KIAA1211L | LN22 | Human | Oral cavity | OSCC | 2.66e-06 | 7.52e-01 | 0.1733 |
| 343990 | KIAA1211L | LN46 | Human | Oral cavity | OSCC | 3.47e-22 | 8.34e-01 | 0.1666 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| KIAA1211L | SNV | Missense_Mutation | c.375N>T | p.Gln125His | p.Q125H | Q6NV74 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
| KIAA1211L | insertion | Frame_Shift_Ins | novel | c.302_303insGATGCTGCCACATTTTAAATTCTTTATGTTATTGTGGT | p.Gly102MetfsTer38 | p.G102Mfs*38 | Q6NV74 | protein_coding | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
| KIAA1211L | insertion | Frame_Shift_Ins | novel | c.2451_2452insAAAATACAAAAATTAGCCAGCATGGTGGTGCGTGC | p.Ala818LysfsTer48 | p.A818Kfs*48 | Q6NV74 | protein_coding | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| KIAA1211L | SNV | Missense_Mutation | novel | c.802C>T | p.Pro268Ser | p.P268S | Q6NV74 | protein_coding | tolerated(0.31) | benign(0.023) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| KIAA1211L | SNV | Missense_Mutation | novel | c.108T>A | p.Phe36Leu | p.F36L | Q6NV74 | protein_coding | tolerated(0.19) | benign(0.024) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| KIAA1211L | SNV | Missense_Mutation | c.1375N>C | p.Glu459Gln | p.E459Q | Q6NV74 | protein_coding | deleterious(0.05) | possibly_damaging(0.607) | TCGA-C5-A1M6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
| KIAA1211L | SNV | Missense_Mutation | novel | c.2450G>C | p.Gly817Ala | p.G817A | Q6NV74 | protein_coding | tolerated(0.14) | benign(0.154) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
| KIAA1211L | SNV | Missense_Mutation | rs775019973 | c.2593G>A | p.Glu865Lys | p.E865K | Q6NV74 | protein_coding | deleterious(0.04) | possibly_damaging(0.739) | TCGA-AA-3548-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
| KIAA1211L | SNV | Missense_Mutation | novel | c.358C>T | p.Arg120Trp | p.R120W | Q6NV74 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| KIAA1211L | SNV | Missense_Mutation | c.1147C>T | p.Pro383Ser | p.P383S | Q6NV74 | protein_coding | tolerated(0.7) | benign(0.178) | TCGA-AD-A5EK-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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