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Gene: KIAA1211 |
Gene summary for KIAA1211 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | KIAA1211 | Gene ID | 57482 |
| Gene name | capping protein inhibiting regulator of actin dynamics | |
| Gene Alias | CRAD | |
| Cytomap | 4q12 | |
| Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | Q6ZU35 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57482 | KIAA1211 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.37e-21 | -6.33e-01 | 0.0155 |
| 57482 | KIAA1211 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.52e-12 | -6.33e-01 | -0.1808 |
| 57482 | KIAA1211 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.93e-02 | -6.33e-01 | 0.0216 |
| 57482 | KIAA1211 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.36e-09 | -6.33e-01 | -0.0811 |
| 57482 | KIAA1211 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.93e-15 | -6.33e-01 | -0.1088 |
| 57482 | KIAA1211 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.24e-23 | -6.33e-01 | -0.1954 |
| 57482 | KIAA1211 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.60e-10 | -6.33e-01 | -0.1207 |
| 57482 | KIAA1211 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.22e-07 | -6.33e-01 | -0.1526 |
| 57482 | KIAA1211 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.96e-35 | -6.33e-01 | -0.1464 |
| 57482 | KIAA1211 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.49e-32 | -6.33e-01 | -0.1001 |
| 57482 | KIAA1211 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.15e-17 | -6.33e-01 | -0.059 |
| 57482 | KIAA1211 | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.36e-03 | -6.33e-01 | -0.1706 |
| 57482 | KIAA1211 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.06e-03 | -6.33e-01 | -0.2061 |
| 57482 | KIAA1211 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.93e-02 | -6.33e-01 | -0.1462 |
| 57482 | KIAA1211 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.74e-06 | -6.33e-01 | -0.0842 |
| 57482 | KIAA1211 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.57e-05 | -6.33e-01 | -0.0179 |
| 57482 | KIAA1211 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.35e-19 | -6.33e-01 | 0.096 |
| 57482 | KIAA1211 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.93e-02 | -6.33e-01 | 0.0446 |
| 57482 | KIAA1211 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.77e-04 | -6.33e-01 | 0.0528 |
| 57482 | KIAA1211 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.61e-02 | -6.33e-01 | 0.0131 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| KIAA1211 | SNV | Missense_Mutation | novel | c.2156N>A | p.Phe719Tyr | p.F719Y | Q6ZU35 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A7-A6VW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
| KIAA1211 | SNV | Missense_Mutation | c.325C>T | p.Pro109Ser | p.P109S | Q6ZU35 | protein_coding | tolerated(0.12) | benign(0.117) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| KIAA1211 | SNV | Missense_Mutation | novel | c.3459G>T | p.Glu1153Asp | p.E1153D | Q6ZU35 | protein_coding | tolerated(0.11) | benign(0.275) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| KIAA1211 | SNV | Missense_Mutation | c.3196A>G | p.Met1066Val | p.M1066V | Q6ZU35 | protein_coding | tolerated(1) | benign(0) | TCGA-AN-A0XO-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| KIAA1211 | SNV | Missense_Mutation | c.3010N>C | p.Ser1004Pro | p.S1004P | Q6ZU35 | protein_coding | tolerated(0.33) | benign(0.003) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| KIAA1211 | insertion | Nonsense_Mutation | novel | c.1485_1486insAGAAGGGGATGGCTCAAGACAGTGCTGCCGCCCAGACAATGA | p.Glu495_Gly496insArgArgGlyTrpLeuLysThrValLeuProProArgGlnTer | p.E495_G496insRRGWLKTVLPPRQ* | Q6ZU35 | protein_coding | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | ||
| KIAA1211 | insertion | In_Frame_Ins | novel | c.96_97insCACAATGCTGAAAGTGCTTGCCGAATGAGA | p.Ile32_Leu33insHisAsnAlaGluSerAlaCysArgMetArg | p.I32_L33insHNAESACRMR | Q6ZU35 | protein_coding | TCGA-B6-A0IM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| KIAA1211 | SNV | Missense_Mutation | novel | c.3464G>T | p.Arg1155Met | p.R1155M | Q6ZU35 | protein_coding | deleterious(0) | possibly_damaging(0.66) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| KIAA1211 | SNV | Missense_Mutation | rs746156043 | c.571C>T | p.Arg191Trp | p.R191W | Q6ZU35 | protein_coding | deleterious(0) | possibly_damaging(0.533) | TCGA-C5-A1BJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| KIAA1211 | SNV | Missense_Mutation | c.504N>C | p.Gln168His | p.Q168H | Q6ZU35 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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