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Gene: KIAA1161 |
Gene summary for KIAA1161 |
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Gene information | Species | Human | Gene symbol | KIAA1161 | Gene ID | 57462 |
Gene name | myogenesis regulating glycosidase (putative) | |
Gene Alias | IBGC7 | |
Cytomap | 9p13.3 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q6NSJ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57462 | KIAA1161 | HCC1_Meng | Human | Liver | HCC | 7.14e-15 | 4.64e-02 | 0.0246 |
57462 | KIAA1161 | HCC2_Meng | Human | Liver | HCC | 1.05e-05 | 5.28e-02 | 0.0107 |
57462 | KIAA1161 | HCC1 | Human | Liver | HCC | 6.95e-06 | 2.08e+00 | 0.5336 |
57462 | KIAA1161 | HCC2 | Human | Liver | HCC | 6.44e-09 | 2.19e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA1161 | SNV | Missense_Mutation | novel | c.2102N>T | p.Pro701Leu | p.P701L | Q6NSJ0 | protein_coding | deleterious(0.01) | possibly_damaging(0.73) | TCGA-3C-AALK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
KIAA1161 | SNV | Missense_Mutation | c.1163N>T | p.Thr388Met | p.T388M | Q6NSJ0 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-BH-A0E9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
KIAA1161 | SNV | Missense_Mutation | novel | c.1513G>A | p.Val505Ile | p.V505I | Q6NSJ0 | protein_coding | deleterious(0.04) | possibly_damaging(0.891) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA1161 | deletion | Frame_Shift_Del | novel | c.830_831delCA | p.Pro277ArgfsTer90 | p.P277Rfs*90 | Q6NSJ0 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
KIAA1161 | SNV | Missense_Mutation | novel | c.967N>A | p.Leu323Met | p.L323M | Q6NSJ0 | protein_coding | tolerated(0.18) | possibly_damaging(0.893) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KIAA1161 | SNV | Missense_Mutation | novel | c.865G>A | p.Val289Ile | p.V289I | Q6NSJ0 | protein_coding | tolerated(0.27) | benign(0.005) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA1161 | deletion | Frame_Shift_Del | novel | c.668delN | p.Gly223AlafsTer57 | p.G223Afs*57 | Q6NSJ0 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
KIAA1161 | SNV | Missense_Mutation | novel | c.1145N>G | p.Asp382Gly | p.D382G | Q6NSJ0 | protein_coding | tolerated(0.18) | benign(0.03) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA1161 | SNV | Missense_Mutation | novel | c.485N>A | p.Arg162His | p.R162H | Q6NSJ0 | protein_coding | tolerated(0.14) | benign(0.034) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA1161 | SNV | Missense_Mutation | c.1712N>A | p.Arg571His | p.R571H | Q6NSJ0 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AZ-4681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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