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Gene: KIAA1033 |
Gene summary for KIAA1033 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | KIAA1033 | Gene ID | 23325 |
| Gene name | WASH complex subunit 4 | |
| Gene Alias | KIAA1033 | |
| Cytomap | 12q23.3 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A087X256 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 23325 | KIAA1033 | P1T-E | Human | Esophagus | ESCC | 9.47e-12 | 2.82e-01 | 0.0875 |
| 23325 | KIAA1033 | P2T-E | Human | Esophagus | ESCC | 1.55e-35 | 5.86e-01 | 0.1177 |
| 23325 | KIAA1033 | P4T-E | Human | Esophagus | ESCC | 6.10e-21 | 3.76e-01 | 0.1323 |
| 23325 | KIAA1033 | P5T-E | Human | Esophagus | ESCC | 9.14e-19 | 2.00e-01 | 0.1327 |
| 23325 | KIAA1033 | P8T-E | Human | Esophagus | ESCC | 1.37e-25 | 4.31e-01 | 0.0889 |
| 23325 | KIAA1033 | P9T-E | Human | Esophagus | ESCC | 4.04e-03 | 1.41e-01 | 0.1131 |
| 23325 | KIAA1033 | P10T-E | Human | Esophagus | ESCC | 1.83e-16 | 3.08e-01 | 0.116 |
| 23325 | KIAA1033 | P11T-E | Human | Esophagus | ESCC | 8.20e-22 | 7.27e-01 | 0.1426 |
| 23325 | KIAA1033 | P12T-E | Human | Esophagus | ESCC | 2.06e-17 | 3.50e-01 | 0.1122 |
| 23325 | KIAA1033 | P15T-E | Human | Esophagus | ESCC | 1.79e-18 | 3.16e-01 | 0.1149 |
| 23325 | KIAA1033 | P16T-E | Human | Esophagus | ESCC | 1.44e-12 | 2.94e-01 | 0.1153 |
| 23325 | KIAA1033 | P17T-E | Human | Esophagus | ESCC | 1.68e-03 | 4.35e-01 | 0.1278 |
| 23325 | KIAA1033 | P20T-E | Human | Esophagus | ESCC | 9.68e-22 | 4.62e-01 | 0.1124 |
| 23325 | KIAA1033 | P21T-E | Human | Esophagus | ESCC | 2.45e-30 | 6.24e-01 | 0.1617 |
| 23325 | KIAA1033 | P22T-E | Human | Esophagus | ESCC | 1.12e-15 | 2.62e-01 | 0.1236 |
| 23325 | KIAA1033 | P23T-E | Human | Esophagus | ESCC | 1.52e-24 | 4.77e-01 | 0.108 |
| 23325 | KIAA1033 | P24T-E | Human | Esophagus | ESCC | 1.06e-14 | 3.04e-01 | 0.1287 |
| 23325 | KIAA1033 | P26T-E | Human | Esophagus | ESCC | 8.16e-20 | 3.16e-01 | 0.1276 |
| 23325 | KIAA1033 | P27T-E | Human | Esophagus | ESCC | 1.36e-17 | 3.43e-01 | 0.1055 |
| 23325 | KIAA1033 | P28T-E | Human | Esophagus | ESCC | 1.25e-18 | 3.08e-01 | 0.1149 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
| hsa0414419 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
| hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
| hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
| hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
| hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
| hsa0414414 | Lung | IAC | Endocytosis | 51/1053 | 251/8465 | 2.25e-04 | 2.54e-03 | 1.68e-03 | 51 |
| hsa0414415 | Lung | IAC | Endocytosis | 51/1053 | 251/8465 | 2.25e-04 | 2.54e-03 | 1.68e-03 | 51 |
| hsa0414423 | Lung | AIS | Endocytosis | 52/961 | 251/8465 | 9.74e-06 | 3.04e-04 | 1.95e-04 | 52 |
| hsa0414433 | Lung | AIS | Endocytosis | 52/961 | 251/8465 | 9.74e-06 | 3.04e-04 | 1.95e-04 | 52 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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