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Gene: KIAA0930 |
Gene summary for KIAA0930 |
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Gene information | Species | Human | Gene symbol | KIAA0930 | Gene ID | 23313 |
Gene name | KIAA0930 | |
Gene Alias | C22orf9 | |
Cytomap | 22q13.31 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q6ICG6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23313 | KIAA0930 | LZE4T | Human | Esophagus | ESCC | 2.52e-06 | 7.87e-02 | 0.0811 |
23313 | KIAA0930 | LZE5T | Human | Esophagus | ESCC | 1.62e-03 | 4.96e-02 | 0.0514 |
23313 | KIAA0930 | LZE7T | Human | Esophagus | ESCC | 5.65e-06 | 3.91e-01 | 0.0667 |
23313 | KIAA0930 | LZE20T | Human | Esophagus | ESCC | 1.74e-03 | 2.45e-02 | 0.0662 |
23313 | KIAA0930 | LZE22T | Human | Esophagus | ESCC | 1.12e-04 | 7.87e-02 | 0.068 |
23313 | KIAA0930 | LZE24T | Human | Esophagus | ESCC | 8.02e-11 | 3.26e-02 | 0.0596 |
23313 | KIAA0930 | LZE6T | Human | Esophagus | ESCC | 4.47e-03 | -5.03e-02 | 0.0845 |
23313 | KIAA0930 | P1T-E | Human | Esophagus | ESCC | 6.15e-04 | 3.22e-01 | 0.0875 |
23313 | KIAA0930 | P2T-E | Human | Esophagus | ESCC | 1.21e-09 | -2.74e-02 | 0.1177 |
23313 | KIAA0930 | P4T-E | Human | Esophagus | ESCC | 3.95e-10 | 2.59e-01 | 0.1323 |
23313 | KIAA0930 | P5T-E | Human | Esophagus | ESCC | 2.29e-16 | 8.61e-03 | 0.1327 |
23313 | KIAA0930 | P8T-E | Human | Esophagus | ESCC | 6.10e-15 | 1.04e-01 | 0.0889 |
23313 | KIAA0930 | P9T-E | Human | Esophagus | ESCC | 5.88e-15 | 2.06e-01 | 0.1131 |
23313 | KIAA0930 | P10T-E | Human | Esophagus | ESCC | 1.44e-14 | 1.63e-01 | 0.116 |
23313 | KIAA0930 | P11T-E | Human | Esophagus | ESCC | 1.01e-06 | 3.18e-01 | 0.1426 |
23313 | KIAA0930 | P12T-E | Human | Esophagus | ESCC | 1.71e-22 | 2.22e-01 | 0.1122 |
23313 | KIAA0930 | P15T-E | Human | Esophagus | ESCC | 8.67e-16 | 2.94e-01 | 0.1149 |
23313 | KIAA0930 | P16T-E | Human | Esophagus | ESCC | 1.42e-07 | -5.34e-02 | 0.1153 |
23313 | KIAA0930 | P17T-E | Human | Esophagus | ESCC | 1.65e-10 | 2.28e-01 | 0.1278 |
23313 | KIAA0930 | P19T-E | Human | Esophagus | ESCC | 4.84e-03 | 2.03e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0930 | SNV | Missense_Mutation | rs368253058 | c.911G>A | p.Arg304Gln | p.R304Q | Q6ICG6 | protein_coding | tolerated(0.09) | probably_damaging(0.933) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
KIAA0930 | insertion | Nonsense_Mutation | novel | c.947_948insTTCAGGGGATTTCCCACCTTTCTAAG | p.Pro317SerfsTer8 | p.P317Sfs*8 | Q6ICG6 | protein_coding | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | ||
KIAA0930 | insertion | Frame_Shift_Ins | novel | c.945_946insTTGGTCA | p.Val316LeufsTer10 | p.V316Lfs*10 | Q6ICG6 | protein_coding | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | ||
KIAA0930 | insertion | In_Frame_Ins | novel | c.456_457insTTGTGCGCATCCAAGGTGCTCAGGGCCCTGAGG | p.His152_Pro153insLeuCysAlaSerLysValLeuArgAlaLeuArg | p.H152_P153insLCASKVLRALR | Q6ICG6 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KIAA0930 | insertion | Frame_Shift_Ins | novel | c.1044_1045insCACAGCCAGCTCTGCCTCCAGGGCCTTGGTACTTGTGAGCC | p.Ala349HisfsTer35 | p.A349Hfs*35 | Q6ICG6 | protein_coding | TCGA-AO-A0J4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
KIAA0930 | insertion | Nonsense_Mutation | novel | c.116_117insAGTGACCCCCGGCCCCTGCCCCTGCGTCTGT | p.Trp39Ter | p.W39* | Q6ICG6 | protein_coding | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD | ||
KIAA0930 | SNV | Missense_Mutation | rs762931184 | c.194C>T | p.Ala65Val | p.A65V | Q6ICG6 | protein_coding | tolerated(0.4) | benign(0.015) | TCGA-VS-A8EG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA0930 | SNV | Missense_Mutation | rs751295257 | c.685N>A | p.Ala229Thr | p.A229T | Q6ICG6 | protein_coding | tolerated(0.57) | benign(0.024) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
KIAA0930 | SNV | Missense_Mutation | c.268C>T | p.Arg90Trp | p.R90W | Q6ICG6 | protein_coding | deleterious(0.02) | possibly_damaging(0.903) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
KIAA0930 | SNV | Missense_Mutation | c.176N>T | p.Tyr59Phe | p.Y59F | Q6ICG6 | protein_coding | tolerated(0.36) | benign(0.34) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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