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Gene: KIAA0922 |
Gene summary for KIAA0922 |
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Gene information | Species | Human | Gene symbol | KIAA0922 | Gene ID | 23240 |
Gene name | transmembrane 131 like | |
Gene Alias | KIAA0922 | |
Cytomap | 4q31.3 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | A2VDJ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23240 | KIAA0922 | P2T-E | Human | Esophagus | ESCC | 1.40e-38 | 7.41e-01 | 0.1177 |
23240 | KIAA0922 | P4T-E | Human | Esophagus | ESCC | 3.65e-02 | 1.74e-01 | 0.1323 |
23240 | KIAA0922 | P5T-E | Human | Esophagus | ESCC | 3.01e-06 | 9.49e-02 | 0.1327 |
23240 | KIAA0922 | P8T-E | Human | Esophagus | ESCC | 2.03e-13 | 7.55e-02 | 0.0889 |
23240 | KIAA0922 | P9T-E | Human | Esophagus | ESCC | 1.45e-08 | 1.14e-01 | 0.1131 |
23240 | KIAA0922 | P10T-E | Human | Esophagus | ESCC | 2.31e-08 | 7.99e-02 | 0.116 |
23240 | KIAA0922 | P12T-E | Human | Esophagus | ESCC | 1.58e-17 | 3.25e-01 | 0.1122 |
23240 | KIAA0922 | P15T-E | Human | Esophagus | ESCC | 4.30e-12 | 1.28e-01 | 0.1149 |
23240 | KIAA0922 | P16T-E | Human | Esophagus | ESCC | 2.02e-18 | 2.53e-01 | 0.1153 |
23240 | KIAA0922 | P20T-E | Human | Esophagus | ESCC | 1.19e-02 | 7.28e-02 | 0.1124 |
23240 | KIAA0922 | P21T-E | Human | Esophagus | ESCC | 1.71e-10 | 8.61e-02 | 0.1617 |
23240 | KIAA0922 | P22T-E | Human | Esophagus | ESCC | 6.57e-04 | 5.42e-02 | 0.1236 |
23240 | KIAA0922 | P23T-E | Human | Esophagus | ESCC | 5.53e-05 | 1.93e-01 | 0.108 |
23240 | KIAA0922 | P24T-E | Human | Esophagus | ESCC | 8.38e-06 | 1.11e-01 | 0.1287 |
23240 | KIAA0922 | P26T-E | Human | Esophagus | ESCC | 5.79e-20 | 2.38e-01 | 0.1276 |
23240 | KIAA0922 | P27T-E | Human | Esophagus | ESCC | 2.64e-17 | 3.37e-01 | 0.1055 |
23240 | KIAA0922 | P28T-E | Human | Esophagus | ESCC | 2.82e-11 | 7.30e-02 | 0.1149 |
23240 | KIAA0922 | P30T-E | Human | Esophagus | ESCC | 1.90e-07 | 1.81e-01 | 0.137 |
23240 | KIAA0922 | P31T-E | Human | Esophagus | ESCC | 2.31e-03 | 5.50e-02 | 0.1251 |
23240 | KIAA0922 | P32T-E | Human | Esophagus | ESCC | 1.06e-09 | 1.53e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0922 | SNV | Missense_Mutation | novel | c.2722N>A | p.Gln908Lys | p.Q908K | A2VDJ0 | protein_coding | tolerated(1) | benign(0.217) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
KIAA0922 | SNV | Missense_Mutation | novel | c.4067N>G | p.Asp1356Gly | p.D1356G | A2VDJ0 | protein_coding | tolerated(0.23) | benign(0.006) | TCGA-AC-A62Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA0922 | SNV | Missense_Mutation | rs369720504 | c.2071G>A | p.Val691Ile | p.V691I | A2VDJ0 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA0922 | SNV | Missense_Mutation | c.533G>C | p.Gly178Ala | p.G178A | A2VDJ0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B6-A1KF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIAA0922 | SNV | Missense_Mutation | rs201480266 | c.4553N>T | p.Ser1518Phe | p.S1518F | A2VDJ0 | protein_coding | deleterious(0) | possibly_damaging(0.795) | TCGA-BH-A0HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
KIAA0922 | SNV | Missense_Mutation | rs765811285 | c.3783A>G | p.Ile1261Met | p.I1261M | A2VDJ0 | protein_coding | tolerated(0.29) | benign(0.005) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA0922 | SNV | Missense_Mutation | c.3895N>C | p.Asp1299His | p.D1299H | A2VDJ0 | protein_coding | deleterious(0.01) | possibly_damaging(0.81) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
KIAA0922 | SNV | Missense_Mutation | c.4052N>T | p.Ser1351Ile | p.S1351I | A2VDJ0 | protein_coding | deleterious(0.01) | benign(0.109) | TCGA-C8-A130-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
KIAA0922 | SNV | Missense_Mutation | novel | c.4288N>T | p.Val1430Leu | p.V1430L | A2VDJ0 | protein_coding | tolerated(1) | benign(0.005) | TCGA-C8-A1HJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA0922 | insertion | Frame_Shift_Ins | novel | c.1261_1262insC | p.Val421AlafsTer5 | p.V421Afs*5 | A2VDJ0 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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