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Gene: KIAA0825 |
Gene summary for KIAA0825 |
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Gene information | Species | Human | Gene symbol | KIAA0825 | Gene ID | 285600 |
Gene name | KIAA0825 | |
Gene Alias | C5orf36 | |
Cytomap | 5q15 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q8IV33 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285600 | KIAA0825 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.75e-06 | -7.91e-02 | 0.0155 |
285600 | KIAA0825 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.41e-15 | 8.03e-01 | -0.0811 |
285600 | KIAA0825 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.09e-19 | 1.21e+00 | -0.1088 |
285600 | KIAA0825 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.26e-16 | 5.35e-01 | -0.1954 |
285600 | KIAA0825 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.26e-10 | 5.83e-01 | -0.1526 |
285600 | KIAA0825 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.56e-06 | 4.43e-01 | -0.1464 |
285600 | KIAA0825 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.69e-04 | 3.18e-01 | -0.059 |
285600 | KIAA0825 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.76e-04 | 6.47e-01 | -0.1706 |
285600 | KIAA0825 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.47e-02 | 1.43e-01 | -0.2061 |
285600 | KIAA0825 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.77e-03 | -9.24e-02 | 0.096 |
285600 | KIAA0825 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.07e-04 | 2.64e-01 | 0.294 |
285600 | KIAA0825 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.82e-06 | 5.81e-01 | 0.281 |
285600 | KIAA0825 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.74e-05 | -2.53e-01 | 0.3005 |
285600 | KIAA0825 | A015-C-203 | Human | Colorectum | FAP | 2.01e-04 | -1.65e-01 | -0.1294 |
285600 | KIAA0825 | A002-C-205 | Human | Colorectum | FAP | 2.14e-03 | -1.94e-01 | -0.1236 |
285600 | KIAA0825 | A015-C-104 | Human | Colorectum | FAP | 1.13e-03 | -1.88e-01 | -0.1899 |
285600 | KIAA0825 | A002-C-016 | Human | Colorectum | FAP | 8.52e-03 | -1.34e-01 | 0.0521 |
285600 | KIAA0825 | A002-C-116 | Human | Colorectum | FAP | 2.82e-06 | -2.20e-01 | -0.0452 |
285600 | KIAA0825 | NAFLD1 | Human | Liver | NAFLD | 1.10e-05 | 5.81e-01 | -0.04 |
285600 | KIAA0825 | HCC1 | Human | Liver | HCC | 3.47e-13 | 8.76e-01 | 0.5336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0825 | SNV | Missense_Mutation | rs775286023 | c.2756C>G | p.Ser919Cys | p.S919C | protein_coding | deleterious(0) | possibly_damaging(0.847) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
KIAA0825 | SNV | Missense_Mutation | c.2604C>G | p.Asn868Lys | p.N868K | protein_coding | tolerated(0.95) | benign(0.357) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | ||
KIAA0825 | SNV | Missense_Mutation | rs754099690 | c.1027N>A | p.Glu343Lys | p.E343K | protein_coding | tolerated(1) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIAA0825 | SNV | Missense_Mutation | rs374930679 | c.3604A>G | p.Met1202Val | p.M1202V | protein_coding | tolerated(0.75) | benign(0.007) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIAA0825 | SNV | Missense_Mutation | rs530737956 | c.1798N>A | p.Val600Ile | p.V600I | protein_coding | tolerated(0.54) | benign(0.007) | TCGA-E9-A22A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
KIAA0825 | SNV | Missense_Mutation | novel | c.1062N>T | p.Lys354Asn | p.K354N | protein_coding | tolerated(0.37) | benign(0.118) | TCGA-GM-A4E0-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
KIAA0825 | SNV | Missense_Mutation | c.604N>G | p.Leu202Val | p.L202V | Q8IV33 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD | |
KIAA0825 | insertion | Frame_Shift_Ins | novel | c.2552_2553insTAAA | p.Ile852LysfsTer4 | p.I852Kfs*4 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
KIAA0825 | deletion | In_Frame_Del | c.3338_3340delNNN | p.Gly1113del | p.G1113del | protein_coding | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | ||||
KIAA0825 | SNV | Missense_Mutation | novel | c.3728A>T | p.Asp1243Val | p.D1243V | protein_coding | deleterious(0.03) | benign(0.354) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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