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Gene: KIAA0408 |
Gene summary for KIAA0408 |
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Gene information | Species | Human | Gene symbol | KIAA0408 | Gene ID | 9729 |
Gene name | KIAA0408 | |
Gene Alias | KIAA0408 | |
Cytomap | 6q22.33 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q6ZU52 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9729 | KIAA0408 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.02e-16 | 6.79e-01 | -0.2116 |
9729 | KIAA0408 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 3.94e-06 | 6.67e-01 | -0.1941 |
9729 | KIAA0408 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 5.59e-05 | 5.04e-01 | -0.2107 |
9729 | KIAA0408 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.01e-09 | 5.37e-01 | -0.2119 |
9729 | KIAA0408 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 4.20e-04 | 2.24e-01 | -0.0166 |
9729 | KIAA0408 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.22e-08 | 3.74e-01 | -0.0132 |
9729 | KIAA0408 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 3.06e-06 | 2.69e-01 | -0.013 |
9729 | KIAA0408 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 4.42e-08 | 3.42e-01 | -0.0121 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0408 | SNV | Missense_Mutation | novel | c.1345N>C | p.Val449Leu | p.V449L | Q6ZU52 | protein_coding | deleterious(0.02) | possibly_damaging(0.803) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |
KIAA0408 | SNV | Missense_Mutation | c.1241C>T | p.Ser414Leu | p.S414L | Q6ZU52 | protein_coding | tolerated(0.27) | benign(0.006) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KIAA0408 | SNV | Missense_Mutation | c.178G>A | p.Glu60Lys | p.E60K | Q6ZU52 | protein_coding | deleterious(0.01) | possibly_damaging(0.536) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
KIAA0408 | SNV | Missense_Mutation | c.1238N>T | p.Ser413Phe | p.S413F | Q6ZU52 | protein_coding | tolerated(0.34) | benign(0.062) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
KIAA0408 | SNV | Missense_Mutation | c.1485N>T | p.Trp495Cys | p.W495C | Q6ZU52 | protein_coding | tolerated(0.36) | possibly_damaging(0.54) | TCGA-E9-A1R6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
KIAA0408 | insertion | Frame_Shift_Ins | novel | c.366_367insT | p.Lys123Ter | p.K123* | Q6ZU52 | protein_coding | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
KIAA0408 | insertion | Nonsense_Mutation | novel | c.364_365insTCATTGCTTTAGCTATGGTTGCTTTTGAGAGCTTATTCTA | p.Gln122LeufsTer14 | p.Q122Lfs*14 | Q6ZU52 | protein_coding | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
KIAA0408 | deletion | Frame_Shift_Del | c.108_117delNNNNNNNNNN | p.Trp36CysfsTer5 | p.W36Cfs*5 | Q6ZU52 | protein_coding | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
KIAA0408 | SNV | Missense_Mutation | c.1723N>A | p.Glu575Lys | p.E575K | Q6ZU52 | protein_coding | tolerated(0.75) | benign(0.037) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
KIAA0408 | SNV | Missense_Mutation | novel | c.86N>C | p.Arg29Thr | p.R29T | Q6ZU52 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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