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Gene: KIAA0232 |
Gene summary for KIAA0232 |
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Gene information | Species | Human | Gene symbol | KIAA0232 | Gene ID | 9778 |
Gene name | KIAA0232 | |
Gene Alias | KIAA0232 | |
Cytomap | 4p16.1 | |
Gene Type | protein-coding | GO ID | GO:0000166 | UniProtAcc | A5YKK5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9778 | KIAA0232 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.38e-14 | -3.23e-01 | 0.0155 |
9778 | KIAA0232 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.21e-04 | 6.14e-01 | -0.0811 |
9778 | KIAA0232 | HTA11_6818_2000001011 | Human | Colorectum | AD | 6.83e-06 | 7.48e-01 | 0.0112 |
9778 | KIAA0232 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.58e-04 | 5.83e-01 | 0.0588 |
9778 | KIAA0232 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.02e-03 | 4.69e-01 | 0.294 |
9778 | KIAA0232 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.83e-03 | -3.22e-01 | 0.3859 |
9778 | KIAA0232 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.06e-14 | -4.62e-01 | 0.3005 |
9778 | KIAA0232 | A002-C-010 | Human | Colorectum | FAP | 1.88e-02 | -1.47e-01 | 0.242 |
9778 | KIAA0232 | A001-C-207 | Human | Colorectum | FAP | 1.76e-06 | -3.11e-01 | 0.1278 |
9778 | KIAA0232 | A015-C-203 | Human | Colorectum | FAP | 2.64e-25 | -2.79e-01 | -0.1294 |
9778 | KIAA0232 | A015-C-204 | Human | Colorectum | FAP | 3.86e-05 | -1.75e-01 | -0.0228 |
9778 | KIAA0232 | A014-C-040 | Human | Colorectum | FAP | 2.22e-06 | -4.32e-01 | -0.1184 |
9778 | KIAA0232 | A002-C-201 | Human | Colorectum | FAP | 3.52e-12 | -1.98e-01 | 0.0324 |
9778 | KIAA0232 | A002-C-203 | Human | Colorectum | FAP | 4.73e-02 | -6.02e-02 | 0.2786 |
9778 | KIAA0232 | A001-C-119 | Human | Colorectum | FAP | 5.32e-06 | -2.32e-01 | -0.1557 |
9778 | KIAA0232 | A001-C-108 | Human | Colorectum | FAP | 1.21e-14 | -1.54e-01 | -0.0272 |
9778 | KIAA0232 | A002-C-205 | Human | Colorectum | FAP | 1.93e-24 | -1.61e-01 | -0.1236 |
9778 | KIAA0232 | A015-C-005 | Human | Colorectum | FAP | 1.75e-07 | -3.06e-01 | -0.0336 |
9778 | KIAA0232 | A015-C-006 | Human | Colorectum | FAP | 2.37e-19 | -5.81e-01 | -0.0994 |
9778 | KIAA0232 | A015-C-106 | Human | Colorectum | FAP | 1.05e-13 | -2.59e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0232 | SNV | Missense_Mutation | c.918A>T | p.Leu306Phe | p.L306F | Q92628 | protein_coding | tolerated(0.71) | benign(0.105) | TCGA-A1-A0SN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD | |
KIAA0232 | SNV | Missense_Mutation | rs746490506 | c.2555N>T | p.Ser852Leu | p.S852L | Q92628 | protein_coding | deleterious(0.02) | benign(0.123) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
KIAA0232 | SNV | Missense_Mutation | c.3058N>T | p.Asp1020Tyr | p.D1020Y | Q92628 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A8-A075-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | CR | |
KIAA0232 | SNV | Missense_Mutation | c.397N>A | p.Glu133Lys | p.E133K | Q92628 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KIAA0232 | SNV | Missense_Mutation | c.439N>C | p.Glu147Gln | p.E147Q | Q92628 | protein_coding | tolerated(0.12) | benign(0.116) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KIAA0232 | SNV | Missense_Mutation | c.1129N>C | p.Asp377His | p.D377H | Q92628 | protein_coding | deleterious(0) | possibly_damaging(0.747) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KIAA0232 | SNV | Missense_Mutation | rs752327429 | c.1790N>C | p.Ser597Thr | p.S597T | Q92628 | protein_coding | tolerated(0.17) | benign(0.12) | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
KIAA0232 | SNV | Missense_Mutation | novel | c.3679N>A | p.Glu1227Lys | p.E1227K | Q92628 | protein_coding | tolerated_low_confidence(0.31) | benign(0.001) | TCGA-AR-A2LN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD |
KIAA0232 | SNV | Missense_Mutation | c.3757N>G | p.Pro1253Ala | p.P1253A | Q92628 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.692) | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | |
KIAA0232 | SNV | Missense_Mutation | c.1164N>A | p.Met388Ile | p.M388I | Q92628 | protein_coding | tolerated(0.41) | benign(0) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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