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Gene: KIAA0141 |
Gene summary for KIAA0141 |
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Gene information | Species | Human | Gene symbol | KIAA0141 | Gene ID | 9812 |
Gene name | DAP3 binding cell death enhancer 1 | |
Gene Alias | DELE | |
Cytomap | 5q31.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q14154 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9812 | KIAA0141 | P1T-E | Human | Esophagus | ESCC | 3.04e-03 | 2.31e-01 | 0.0875 |
9812 | KIAA0141 | P2T-E | Human | Esophagus | ESCC | 5.86e-22 | 3.93e-01 | 0.1177 |
9812 | KIAA0141 | P4T-E | Human | Esophagus | ESCC | 5.16e-14 | 2.87e-01 | 0.1323 |
9812 | KIAA0141 | P5T-E | Human | Esophagus | ESCC | 1.43e-08 | 1.70e-01 | 0.1327 |
9812 | KIAA0141 | P8T-E | Human | Esophagus | ESCC | 8.16e-10 | 1.79e-01 | 0.0889 |
9812 | KIAA0141 | P9T-E | Human | Esophagus | ESCC | 2.82e-09 | 1.39e-01 | 0.1131 |
9812 | KIAA0141 | P10T-E | Human | Esophagus | ESCC | 1.71e-11 | 1.67e-01 | 0.116 |
9812 | KIAA0141 | P11T-E | Human | Esophagus | ESCC | 1.79e-12 | 5.26e-01 | 0.1426 |
9812 | KIAA0141 | P12T-E | Human | Esophagus | ESCC | 1.46e-21 | 3.52e-01 | 0.1122 |
9812 | KIAA0141 | P15T-E | Human | Esophagus | ESCC | 3.61e-22 | 4.71e-01 | 0.1149 |
9812 | KIAA0141 | P16T-E | Human | Esophagus | ESCC | 2.48e-18 | 2.89e-01 | 0.1153 |
9812 | KIAA0141 | P17T-E | Human | Esophagus | ESCC | 3.01e-02 | 1.40e-01 | 0.1278 |
9812 | KIAA0141 | P19T-E | Human | Esophagus | ESCC | 1.59e-03 | 3.81e-01 | 0.1662 |
9812 | KIAA0141 | P20T-E | Human | Esophagus | ESCC | 5.07e-19 | 4.94e-01 | 0.1124 |
9812 | KIAA0141 | P21T-E | Human | Esophagus | ESCC | 3.20e-19 | 2.87e-01 | 0.1617 |
9812 | KIAA0141 | P22T-E | Human | Esophagus | ESCC | 8.04e-17 | 2.65e-01 | 0.1236 |
9812 | KIAA0141 | P23T-E | Human | Esophagus | ESCC | 2.10e-15 | 3.92e-01 | 0.108 |
9812 | KIAA0141 | P24T-E | Human | Esophagus | ESCC | 1.29e-10 | 2.33e-01 | 0.1287 |
9812 | KIAA0141 | P26T-E | Human | Esophagus | ESCC | 9.14e-26 | 3.47e-01 | 0.1276 |
9812 | KIAA0141 | P27T-E | Human | Esophagus | ESCC | 1.20e-11 | 2.83e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0141 | SNV | Missense_Mutation | c.1117N>T | p.Val373Leu | p.V373L | Q14154 | protein_coding | tolerated(0.27) | probably_damaging(0.995) | TCGA-C8-A12K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIAA0141 | SNV | Missense_Mutation | c.532T>A | p.Ser178Thr | p.S178T | Q14154 | protein_coding | deleterious(0.03) | benign(0.433) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
KIAA0141 | deletion | Frame_Shift_Del | c.268_274delACTCTGG | p.Thr90ProfsTer24 | p.T90Pfs*24 | Q14154 | protein_coding | TCGA-D8-A13Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |||
KIAA0141 | deletion | Frame_Shift_Del | novel | c.624delN | p.Lys209AsnfsTer25 | p.K209Nfs*25 | Q14154 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
KIAA0141 | SNV | Missense_Mutation | c.679N>G | p.Leu227Val | p.L227V | Q14154 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIAA0141 | SNV | Missense_Mutation | rs145284153 | c.227G>A | p.Arg76His | p.R76H | Q14154 | protein_coding | tolerated(0.19) | benign(0) | TCGA-A6-5660-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD |
KIAA0141 | SNV | Missense_Mutation | novel | c.821N>T | p.Arg274Leu | p.R274L | Q14154 | protein_coding | tolerated(0.06) | benign(0.158) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KIAA0141 | SNV | Missense_Mutation | rs137962377 | c.1249N>A | p.Ala417Thr | p.A417T | Q14154 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A02O-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIAA0141 | SNV | Missense_Mutation | novel | c.359N>T | p.Trp120Leu | p.W120L | Q14154 | protein_coding | deleterious(0.01) | possibly_damaging(0.656) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KIAA0141 | SNV | Missense_Mutation | c.299G>T | p.Arg100Met | p.R100M | Q14154 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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