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Gene: KIAA0100 |
Gene summary for KIAA0100 |
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Gene information | Species | Human | Gene symbol | KIAA0100 | Gene ID | 9703 |
Gene name | KIAA0100 | |
Gene Alias | BCOX | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q14667 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9703 | KIAA0100 | LZE7T | Human | Esophagus | ESCC | 1.33e-05 | 2.82e-01 | 0.0667 |
9703 | KIAA0100 | LZE21D1 | Human | Esophagus | HGIN | 2.21e-03 | 2.10e-01 | 0.0632 |
9703 | KIAA0100 | LZE22T | Human | Esophagus | ESCC | 2.37e-02 | 2.83e-01 | 0.068 |
9703 | KIAA0100 | LZE24T | Human | Esophagus | ESCC | 4.99e-12 | 3.02e-01 | 0.0596 |
9703 | KIAA0100 | LZE21T | Human | Esophagus | ESCC | 2.26e-02 | 2.69e-01 | 0.0655 |
9703 | KIAA0100 | P1T-E | Human | Esophagus | ESCC | 1.11e-12 | 3.62e-01 | 0.0875 |
9703 | KIAA0100 | P2T-E | Human | Esophagus | ESCC | 1.08e-17 | 2.90e-01 | 0.1177 |
9703 | KIAA0100 | P4T-E | Human | Esophagus | ESCC | 8.72e-19 | 3.79e-01 | 0.1323 |
9703 | KIAA0100 | P5T-E | Human | Esophagus | ESCC | 8.33e-11 | 2.00e-01 | 0.1327 |
9703 | KIAA0100 | P8T-E | Human | Esophagus | ESCC | 9.20e-17 | 3.18e-01 | 0.0889 |
9703 | KIAA0100 | P9T-E | Human | Esophagus | ESCC | 3.63e-12 | 1.69e-01 | 0.1131 |
9703 | KIAA0100 | P10T-E | Human | Esophagus | ESCC | 1.05e-30 | 5.93e-01 | 0.116 |
9703 | KIAA0100 | P11T-E | Human | Esophagus | ESCC | 2.46e-08 | 3.23e-01 | 0.1426 |
9703 | KIAA0100 | P12T-E | Human | Esophagus | ESCC | 1.60e-12 | 2.11e-01 | 0.1122 |
9703 | KIAA0100 | P15T-E | Human | Esophagus | ESCC | 1.11e-09 | 2.47e-01 | 0.1149 |
9703 | KIAA0100 | P16T-E | Human | Esophagus | ESCC | 1.40e-14 | 2.28e-01 | 0.1153 |
9703 | KIAA0100 | P17T-E | Human | Esophagus | ESCC | 1.15e-10 | 3.34e-01 | 0.1278 |
9703 | KIAA0100 | P19T-E | Human | Esophagus | ESCC | 4.18e-06 | 3.23e-01 | 0.1662 |
9703 | KIAA0100 | P20T-E | Human | Esophagus | ESCC | 3.83e-13 | 2.21e-01 | 0.1124 |
9703 | KIAA0100 | P21T-E | Human | Esophagus | ESCC | 4.04e-16 | 4.41e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0100 | SNV | Missense_Mutation | novel | c.5221N>C | p.Asp1741His | p.D1741H | Q14667 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
KIAA0100 | SNV | Missense_Mutation | c.476N>G | p.Ile159Ser | p.I159S | Q14667 | protein_coding | tolerated(0.13) | benign(0.062) | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
KIAA0100 | SNV | Missense_Mutation | c.1229N>T | p.Arg410Ile | p.R410I | Q14667 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIAA0100 | SNV | Missense_Mutation | rs757189429 | c.4442N>A | p.Arg1481His | p.R1481H | Q14667 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA0100 | SNV | Missense_Mutation | novel | c.1727N>C | p.Leu576Ser | p.L576S | Q14667 | protein_coding | deleterious(0) | possibly_damaging(0.697) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA0100 | SNV | Missense_Mutation | rs769233124 | c.2881C>G | p.Arg961Gly | p.R961G | Q14667 | protein_coding | deleterious(0.02) | benign(0.136) | TCGA-AN-A0FY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA0100 | SNV | Missense_Mutation | c.5008N>C | p.Glu1670Gln | p.E1670Q | Q14667 | protein_coding | deleterious(0.02) | probably_damaging(0.979) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
KIAA0100 | SNV | Missense_Mutation | c.2056N>G | p.Leu686Val | p.L686V | Q14667 | protein_coding | tolerated(0.1) | benign(0.073) | TCGA-GM-A2DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | PD | |
KIAA0100 | SNV | Missense_Mutation | c.1441N>A | p.Gln481Lys | p.Q481K | Q14667 | protein_coding | tolerated(0.05) | probably_damaging(0.987) | TCGA-PL-A8LV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
KIAA0100 | deletion | Frame_Shift_Del | novel | c.5895delN | p.Asn1966MetfsTer6 | p.N1966Mfs*6 | Q14667 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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