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Gene: KDM5C |
Gene summary for KDM5C |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | KDM5C | Gene ID | 8242 |
| Gene name | lysine demethylase 5C | |
| Gene Alias | DXS1272E | |
| Cytomap | Xp11.22 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P41229 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 8242 | KDM5C | LZE4T | Human | Esophagus | ESCC | 2.39e-05 | 8.70e-02 | 0.0811 |
| 8242 | KDM5C | LZE7T | Human | Esophagus | ESCC | 7.96e-06 | 4.00e-01 | 0.0667 |
| 8242 | KDM5C | LZE8T | Human | Esophagus | ESCC | 2.01e-07 | 2.90e-01 | 0.067 |
| 8242 | KDM5C | LZE20T | Human | Esophagus | ESCC | 9.10e-08 | 1.34e-01 | 0.0662 |
| 8242 | KDM5C | LZE24T | Human | Esophagus | ESCC | 5.52e-13 | 4.39e-01 | 0.0596 |
| 8242 | KDM5C | LZE21T | Human | Esophagus | ESCC | 4.50e-05 | 2.16e-01 | 0.0655 |
| 8242 | KDM5C | P1T-E | Human | Esophagus | ESCC | 2.52e-05 | 3.09e-01 | 0.0875 |
| 8242 | KDM5C | P2T-E | Human | Esophagus | ESCC | 1.34e-39 | 7.13e-01 | 0.1177 |
| 8242 | KDM5C | P4T-E | Human | Esophagus | ESCC | 1.53e-17 | 3.43e-01 | 0.1323 |
| 8242 | KDM5C | P5T-E | Human | Esophagus | ESCC | 3.61e-11 | 1.04e-01 | 0.1327 |
| 8242 | KDM5C | P8T-E | Human | Esophagus | ESCC | 1.04e-32 | 5.95e-01 | 0.0889 |
| 8242 | KDM5C | P9T-E | Human | Esophagus | ESCC | 2.83e-04 | 1.66e-01 | 0.1131 |
| 8242 | KDM5C | P10T-E | Human | Esophagus | ESCC | 4.17e-11 | 1.76e-01 | 0.116 |
| 8242 | KDM5C | P11T-E | Human | Esophagus | ESCC | 7.99e-14 | 5.35e-01 | 0.1426 |
| 8242 | KDM5C | P12T-E | Human | Esophagus | ESCC | 2.05e-05 | 1.44e-01 | 0.1122 |
| 8242 | KDM5C | P15T-E | Human | Esophagus | ESCC | 6.65e-14 | 2.45e-01 | 0.1149 |
| 8242 | KDM5C | P16T-E | Human | Esophagus | ESCC | 1.06e-18 | 3.43e-01 | 0.1153 |
| 8242 | KDM5C | P17T-E | Human | Esophagus | ESCC | 1.20e-07 | 3.77e-01 | 0.1278 |
| 8242 | KDM5C | P20T-E | Human | Esophagus | ESCC | 5.57e-08 | 1.91e-01 | 0.1124 |
| 8242 | KDM5C | P21T-E | Human | Esophagus | ESCC | 1.16e-11 | 1.25e-01 | 0.1617 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
| GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
| GO:000963620 | Esophagus | ESCC | response to toxic substance | 150/8552 | 262/18723 | 1.00e-04 | 7.12e-04 | 150 |
| GO:004851118 | Esophagus | ESCC | rhythmic process | 164/8552 | 298/18723 | 6.80e-04 | 3.57e-03 | 164 |
| GO:00064824 | Esophagus | ESCC | protein demethylation | 24/8552 | 33/18723 | 1.50e-03 | 7.06e-03 | 24 |
| GO:00082144 | Esophagus | ESCC | protein dealkylation | 24/8552 | 33/18723 | 1.50e-03 | 7.06e-03 | 24 |
| GO:00165773 | Esophagus | ESCC | histone demethylation | 22/8552 | 31/18723 | 3.90e-03 | 1.58e-02 | 22 |
| GO:00700763 | Esophagus | ESCC | histone lysine demethylation | 20/8552 | 28/18723 | 5.23e-03 | 1.97e-02 | 20 |
| GO:001657021 | Liver | HCC | histone modification | 283/7958 | 463/18723 | 2.68e-16 | 2.33e-14 | 283 |
| GO:000963622 | Liver | HCC | response to toxic substance | 153/7958 | 262/18723 | 1.37e-07 | 2.58e-06 | 153 |
| GO:004851121 | Liver | HCC | rhythmic process | 156/7958 | 298/18723 | 3.54e-04 | 2.46e-03 | 156 |
| GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
| GO:00165707 | Oral cavity | OSCC | histone modification | 270/7305 | 463/18723 | 1.59e-17 | 1.50e-15 | 270 |
| GO:004851116 | Oral cavity | OSCC | rhythmic process | 157/7305 | 298/18723 | 1.00e-06 | 1.36e-05 | 157 |
| GO:000963618 | Oral cavity | OSCC | response to toxic substance | 137/7305 | 262/18723 | 7.94e-06 | 8.52e-05 | 137 |
| GO:000632510 | Oral cavity | OSCC | chromatin organization | 190/7305 | 409/18723 | 1.17e-03 | 5.97e-03 | 190 |
| GO:001657023 | Oral cavity | EOLP | histone modification | 98/2218 | 463/18723 | 5.58e-09 | 2.96e-07 | 98 |
| GO:004851117 | Oral cavity | EOLP | rhythmic process | 69/2218 | 298/18723 | 2.68e-08 | 1.11e-06 | 69 |
| GO:000632515 | Oral cavity | EOLP | chromatin organization | 84/2218 | 409/18723 | 2.68e-07 | 8.16e-06 | 84 |
| GO:000963625 | Oral cavity | EOLP | response to toxic substance | 48/2218 | 262/18723 | 1.37e-03 | 9.49e-03 | 48 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| KDM5C | SNV | Missense_Mutation | c.2941G>A | p.Glu981Lys | p.E981K | P41229 | protein_coding | deleterious(0.01) | possibly_damaging(0.902) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
| KDM5C | SNV | Missense_Mutation | novel | c.1377A>C | p.Lys459Asn | p.K459N | P41229 | protein_coding | deleterious(0.02) | benign(0.382) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| KDM5C | SNV | Missense_Mutation | c.3820N>A | p.Glu1274Lys | p.E1274K | P41229 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| KDM5C | SNV | Missense_Mutation | c.1988N>T | p.Ala663Val | p.A663V | P41229 | protein_coding | deleterious(0) | possibly_damaging(0.659) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| KDM5C | SNV | Missense_Mutation | c.3883N>C | p.Ala1295Pro | p.A1295P | P41229 | protein_coding | deleterious(0.01) | possibly_damaging(0.701) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| KDM5C | SNV | Missense_Mutation | c.3881N>T | p.Gln1294Leu | p.Q1294L | P41229 | protein_coding | deleterious(0) | possibly_damaging(0.548) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| KDM5C | SNV | Missense_Mutation | c.3319N>C | p.Asp1107His | p.D1107H | P41229 | protein_coding | deleterious(0.02) | benign(0.053) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
| KDM5C | insertion | In_Frame_Ins | novel | c.3227_3228insACC | p.Leu1076_Thr1077insPro | p.L1076_T1077insP | P41229 | protein_coding | TCGA-A7-A26E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | SD | ||
| KDM5C | insertion | Frame_Shift_Ins | novel | c.3226_3227insCGACAGG | p.Leu1076ProfsTer56 | p.L1076Pfs*56 | P41229 | protein_coding | TCGA-A7-A26E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | SD | ||
| KDM5C | insertion | Nonsense_Mutation | novel | c.1625_1626insCAATTA | p.Ala542_Glu543insAsnTer | p.A542_E543insN* | P41229 | protein_coding | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 8242 | KDM5C | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | inhibitor | 310264759 | ||
| 8242 | KDM5C | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | inhibitor | 178103605 | ||
| 8242 | KDM5C | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | EVEROLIMUS | EVEROLIMUS | 27751729 | |
| 8242 | KDM5C | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | inhibitor | 249565909 | ||
| 8242 | KDM5C | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | inhibitor | 178103606 | ||
| 8242 | KDM5C | DRUGGABLE GENOME, ENZYME, CLINICALLY ACTIONABLE | SUNITINIB | SUNITINIB | 27751729 |
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