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Gene: KDELC2 |
Gene summary for KDELC2 |
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Gene information | Species | Human | Gene symbol | KDELC2 | Gene ID | 143888 |
Gene name | protein O-glucosyltransferase 3 | |
Gene Alias | KDELC2 | |
Cytomap | 11q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A024R3C4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
143888 | KDELC2 | P2T-E | Human | Esophagus | ESCC | 6.31e-18 | 3.02e-01 | 0.1177 |
143888 | KDELC2 | P4T-E | Human | Esophagus | ESCC | 2.14e-16 | 4.11e-01 | 0.1323 |
143888 | KDELC2 | P9T-E | Human | Esophagus | ESCC | 1.77e-07 | 2.35e-01 | 0.1131 |
143888 | KDELC2 | P10T-E | Human | Esophagus | ESCC | 3.08e-12 | 2.05e-01 | 0.116 |
143888 | KDELC2 | P11T-E | Human | Esophagus | ESCC | 3.69e-08 | 3.79e-01 | 0.1426 |
143888 | KDELC2 | P12T-E | Human | Esophagus | ESCC | 3.18e-15 | 3.00e-01 | 0.1122 |
143888 | KDELC2 | P15T-E | Human | Esophagus | ESCC | 5.38e-03 | 8.60e-02 | 0.1149 |
143888 | KDELC2 | P16T-E | Human | Esophagus | ESCC | 5.04e-10 | 2.64e-01 | 0.1153 |
143888 | KDELC2 | P17T-E | Human | Esophagus | ESCC | 4.69e-02 | 1.09e-01 | 0.1278 |
143888 | KDELC2 | P19T-E | Human | Esophagus | ESCC | 1.95e-04 | 2.66e-01 | 0.1662 |
143888 | KDELC2 | P20T-E | Human | Esophagus | ESCC | 4.47e-06 | 9.78e-02 | 0.1124 |
143888 | KDELC2 | P21T-E | Human | Esophagus | ESCC | 8.73e-18 | 3.23e-01 | 0.1617 |
143888 | KDELC2 | P22T-E | Human | Esophagus | ESCC | 1.42e-08 | 6.23e-02 | 0.1236 |
143888 | KDELC2 | P23T-E | Human | Esophagus | ESCC | 1.17e-02 | 7.01e-02 | 0.108 |
143888 | KDELC2 | P24T-E | Human | Esophagus | ESCC | 3.55e-03 | 8.09e-02 | 0.1287 |
143888 | KDELC2 | P26T-E | Human | Esophagus | ESCC | 1.86e-04 | 7.85e-02 | 0.1276 |
143888 | KDELC2 | P27T-E | Human | Esophagus | ESCC | 1.24e-06 | 1.48e-01 | 0.1055 |
143888 | KDELC2 | P28T-E | Human | Esophagus | ESCC | 6.27e-07 | 5.56e-02 | 0.1149 |
143888 | KDELC2 | P30T-E | Human | Esophagus | ESCC | 1.50e-07 | 5.21e-01 | 0.137 |
143888 | KDELC2 | P31T-E | Human | Esophagus | ESCC | 3.53e-03 | 1.03e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KDELC2 | SNV | Missense_Mutation | novel | c.656N>G | p.Asp219Gly | p.D219G | Q7Z4H8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A090-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KDELC2 | SNV | Missense_Mutation | c.799N>A | p.Asp267Asn | p.D267N | Q7Z4H8 | protein_coding | tolerated(0.12) | benign(0.135) | TCGA-AN-A0FV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KDELC2 | SNV | Missense_Mutation | c.241N>A | p.Pro81Thr | p.P81T | Q7Z4H8 | protein_coding | tolerated(0.14) | benign(0.012) | TCGA-E9-A1R5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
KDELC2 | SNV | Missense_Mutation | rs776801689 | c.1429N>A | p.Glu477Lys | p.E477K | Q7Z4H8 | protein_coding | tolerated(0.96) | benign(0.003) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KDELC2 | SNV | Missense_Mutation | c.1390G>A | p.Val464Ile | p.V464I | Q7Z4H8 | protein_coding | deleterious(0.01) | benign(0.158) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KDELC2 | SNV | Missense_Mutation | c.518N>C | p.Ile173Thr | p.I173T | Q7Z4H8 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
KDELC2 | SNV | Missense_Mutation | rs776801689 | c.1429N>A | p.Glu477Lys | p.E477K | Q7Z4H8 | protein_coding | tolerated(0.96) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
KDELC2 | SNV | Missense_Mutation | rs752556893 | c.1253N>T | p.Arg418Ile | p.R418I | Q7Z4H8 | protein_coding | deleterious(0.01) | possibly_damaging(0.837) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KDELC2 | SNV | Missense_Mutation | rs750568803 | c.257N>A | p.Arg86Gln | p.R86Q | Q7Z4H8 | protein_coding | tolerated(0.05) | benign(0.281) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
KDELC2 | insertion | Frame_Shift_Ins | novel | c.906_907insGTAAT | p.Ser303ValfsTer36 | p.S303Vfs*36 | Q7Z4H8 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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