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Gene: KCTD7 |
Gene summary for KCTD7 |
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Gene information | Species | Human | Gene symbol | KCTD7 | Gene ID | 154881 |
Gene name | potassium channel tetramerization domain containing 7 | |
Gene Alias | CLN14 | |
Cytomap | 7q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q96MP8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
154881 | KCTD7 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.55e-09 | 1.88e-01 | 0.0155 |
154881 | KCTD7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.65e-07 | 2.06e-01 | -0.1808 |
154881 | KCTD7 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.22e-05 | 2.80e-01 | 0.0216 |
154881 | KCTD7 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.73e-09 | 3.30e-01 | -0.0811 |
154881 | KCTD7 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.20e-05 | 1.98e-01 | -0.1088 |
154881 | KCTD7 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.04e-22 | 4.11e-01 | -0.1954 |
154881 | KCTD7 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.61e-03 | 2.55e-01 | -0.2602 |
154881 | KCTD7 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.91e-05 | 2.24e-01 | -0.1207 |
154881 | KCTD7 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.46e-11 | 3.59e-01 | -0.1526 |
154881 | KCTD7 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.20e-20 | 3.58e-01 | -0.1464 |
154881 | KCTD7 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.19e-14 | 2.78e-01 | -0.1001 |
154881 | KCTD7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.00e-13 | 2.86e-01 | -0.059 |
154881 | KCTD7 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.34e-04 | 2.80e-01 | -0.1462 |
154881 | KCTD7 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.76e-07 | 3.47e-01 | -0.0842 |
154881 | KCTD7 | HTA11_9341_2000001011 | Human | Colorectum | SER | 5.61e-03 | 2.94e-01 | -0.00410000000000005 |
154881 | KCTD7 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.28e-08 | 2.00e-01 | 0.096 |
154881 | KCTD7 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.40e-02 | 2.22e-01 | 0.0446 |
154881 | KCTD7 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.05e-04 | 2.26e-01 | -0.0177 |
154881 | KCTD7 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.30e-12 | 3.37e-01 | 0.0338 |
154881 | KCTD7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.83e-12 | 2.51e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030004 | Colorectum | AD | cellular monovalent inorganic cation homeostasis | 36/3918 | 103/18723 | 6.80e-04 | 6.95e-03 | 36 |
GO:0055067 | Colorectum | AD | monovalent inorganic cation homeostasis | 45/3918 | 151/18723 | 6.19e-03 | 3.88e-02 | 45 |
GO:0032411 | Colorectum | AD | positive regulation of transporter activity | 37/3918 | 120/18723 | 6.82e-03 | 4.22e-02 | 37 |
GO:00300041 | Colorectum | SER | cellular monovalent inorganic cation homeostasis | 31/2897 | 103/18723 | 1.31e-04 | 2.66e-03 | 31 |
GO:00324111 | Colorectum | SER | positive regulation of transporter activity | 31/2897 | 120/18723 | 2.25e-03 | 2.16e-02 | 31 |
GO:00550671 | Colorectum | SER | monovalent inorganic cation homeostasis | 37/2897 | 151/18723 | 2.48e-03 | 2.33e-02 | 37 |
GO:0032409 | Colorectum | SER | regulation of transporter activity | 65/2897 | 310/18723 | 5.71e-03 | 4.19e-02 | 65 |
GO:00324091 | Colorectum | MSS | regulation of transporter activity | 78/3467 | 310/18723 | 2.09e-03 | 1.78e-02 | 78 |
GO:00300042 | Colorectum | MSS | cellular monovalent inorganic cation homeostasis | 31/3467 | 103/18723 | 2.94e-03 | 2.27e-02 | 31 |
GO:00324112 | Colorectum | MSS | positive regulation of transporter activity | 35/3467 | 120/18723 | 2.95e-03 | 2.28e-02 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCTD7 | SNV | Missense_Mutation | c.335G>T | p.Arg112Leu | p.R112L | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
KCTD7 | insertion | Nonsense_Mutation | novel | c.763_764insCTAACACATTATGAGGTTTTATTGTTTTCTCCAATTTT | p.Gln255ProfsTer5 | p.Q255Pfs*5 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | |||
KCTD7 | SNV | Missense_Mutation | rs772773351 | c.217G>A | p.Glu73Lys | p.E73K | protein_coding | tolerated(0.08) | possibly_damaging(0.49) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
KCTD7 | SNV | Missense_Mutation | novel | c.211T>C | p.Cys71Arg | p.C71R | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KCTD7 | SNV | Missense_Mutation | rs768924233 | c.836G>A | p.Arg279His | p.R279H | protein_coding | deleterious(0.02) | probably_damaging(0.98) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KCTD7 | SNV | Missense_Mutation | novel | c.617T>C | p.Leu206Pro | p.L206P | protein_coding | tolerated(0.25) | benign(0.136) | TCGA-AA-A02E-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
KCTD7 | SNV | Missense_Mutation | rs772773351 | c.217N>A | p.Glu73Lys | p.E73K | protein_coding | tolerated(0.08) | possibly_damaging(0.49) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KCTD7 | SNV | Missense_Mutation | rs200415747 | c.793G>A | p.Gly265Arg | p.G265R | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KCTD7 | SNV | Missense_Mutation | c.695T>G | p.Phe232Cys | p.F232C | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | ||
KCTD7 | SNV | Missense_Mutation | novel | c.683N>C | p.Val228Ala | p.V228A | protein_coding | tolerated(0.76) | probably_damaging(0.956) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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