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Gene: KCTD20 |
Gene summary for KCTD20 |
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Gene information | Species | Human | Gene symbol | KCTD20 | Gene ID | 222658 |
Gene name | potassium channel tetramerization domain containing 20 | |
Gene Alias | C6orf69 | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0006793 | UniProtAcc | Q7Z5Y7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
222658 | KCTD20 | LZE4T | Human | Esophagus | ESCC | 2.19e-11 | 2.80e-01 | 0.0811 |
222658 | KCTD20 | LZE7T | Human | Esophagus | ESCC | 1.69e-07 | 3.53e-01 | 0.0667 |
222658 | KCTD20 | LZE8T | Human | Esophagus | ESCC | 8.64e-07 | 2.08e-01 | 0.067 |
222658 | KCTD20 | LZE22T | Human | Esophagus | ESCC | 4.88e-03 | 4.99e-01 | 0.068 |
222658 | KCTD20 | LZE24T | Human | Esophagus | ESCC | 9.51e-16 | 4.25e-01 | 0.0596 |
222658 | KCTD20 | LZE21T | Human | Esophagus | ESCC | 8.32e-06 | 3.41e-01 | 0.0655 |
222658 | KCTD20 | LZE6T | Human | Esophagus | ESCC | 1.76e-04 | 1.27e-01 | 0.0845 |
222658 | KCTD20 | P1T-E | Human | Esophagus | ESCC | 4.66e-05 | 3.06e-01 | 0.0875 |
222658 | KCTD20 | P2T-E | Human | Esophagus | ESCC | 5.56e-33 | 6.76e-01 | 0.1177 |
222658 | KCTD20 | P4T-E | Human | Esophagus | ESCC | 1.72e-16 | 4.41e-01 | 0.1323 |
222658 | KCTD20 | P5T-E | Human | Esophagus | ESCC | 9.19e-15 | 2.97e-01 | 0.1327 |
222658 | KCTD20 | P8T-E | Human | Esophagus | ESCC | 2.62e-15 | 3.00e-01 | 0.0889 |
222658 | KCTD20 | P9T-E | Human | Esophagus | ESCC | 8.74e-18 | 3.21e-01 | 0.1131 |
222658 | KCTD20 | P10T-E | Human | Esophagus | ESCC | 1.59e-18 | 3.83e-01 | 0.116 |
222658 | KCTD20 | P11T-E | Human | Esophagus | ESCC | 1.04e-15 | 4.53e-01 | 0.1426 |
222658 | KCTD20 | P12T-E | Human | Esophagus | ESCC | 9.12e-14 | 3.48e-01 | 0.1122 |
222658 | KCTD20 | P15T-E | Human | Esophagus | ESCC | 1.55e-15 | 4.48e-01 | 0.1149 |
222658 | KCTD20 | P16T-E | Human | Esophagus | ESCC | 1.62e-21 | 2.09e-01 | 0.1153 |
222658 | KCTD20 | P17T-E | Human | Esophagus | ESCC | 2.18e-09 | 4.00e-01 | 0.1278 |
222658 | KCTD20 | P19T-E | Human | Esophagus | ESCC | 1.12e-04 | 5.40e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCTD20 | SNV | Missense_Mutation | novel | c.328A>C | p.Asn110His | p.N110H | Q7Z5Y7 | protein_coding | deleterious(0.04) | benign(0.172) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KCTD20 | SNV | Missense_Mutation | c.502N>A | p.Glu168Lys | p.E168K | Q7Z5Y7 | protein_coding | deleterious(0.03) | possibly_damaging(0.766) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KCTD20 | SNV | Missense_Mutation | novel | c.1123C>G | p.Leu375Val | p.L375V | Q7Z5Y7 | protein_coding | tolerated(0.66) | benign(0.1) | TCGA-JL-A3YW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KCTD20 | insertion | Frame_Shift_Ins | novel | c.1233_1234insATATTCCACATTTCCTTAACTGTTTCTCATATAGT | p.Met412IlefsTer51 | p.M412Ifs*51 | Q7Z5Y7 | protein_coding | TCGA-BH-A0DS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
KCTD20 | SNV | Missense_Mutation | rs754018529 | c.985G>C | p.Glu329Gln | p.E329Q | Q7Z5Y7 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KCTD20 | SNV | Missense_Mutation | rs367786498 | c.526N>T | p.Arg176Cys | p.R176C | Q7Z5Y7 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KCTD20 | SNV | Missense_Mutation | c.269N>G | p.Asn90Ser | p.N90S | Q7Z5Y7 | protein_coding | tolerated_low_confidence(0.78) | benign(0) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KCTD20 | SNV | Missense_Mutation | rs182729907 | c.644N>A | p.Arg215Gln | p.R215Q | Q7Z5Y7 | protein_coding | tolerated(0.1) | benign(0.163) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KCTD20 | SNV | Missense_Mutation | novel | c.351G>T | p.Glu117Asp | p.E117D | Q7Z5Y7 | protein_coding | tolerated(0.15) | benign(0.089) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KCTD20 | SNV | Missense_Mutation | c.859N>A | p.Leu287Ile | p.L287I | Q7Z5Y7 | protein_coding | tolerated(0.87) | benign(0.022) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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