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Gene: KCTD2 |
Gene summary for KCTD2 |
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Gene information | Species | Human | Gene symbol | KCTD2 | Gene ID | 23510 |
Gene name | potassium channel tetramerization domain containing 2 | |
Gene Alias | KCTD2 | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q14681 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23510 | KCTD2 | HCC1_Meng | Human | Liver | HCC | 4.60e-12 | 2.53e-02 | 0.0246 |
23510 | KCTD2 | HCC1 | Human | Liver | HCC | 4.00e-02 | 1.91e+00 | 0.5336 |
23510 | KCTD2 | HCC2 | Human | Liver | HCC | 2.78e-04 | 2.49e+00 | 0.5341 |
23510 | KCTD2 | Pt14.a | Human | Liver | HCC | 8.14e-05 | 2.72e-01 | 0.0169 |
23510 | KCTD2 | S014 | Human | Liver | HCC | 3.25e-08 | 2.30e-01 | 0.2254 |
23510 | KCTD2 | S015 | Human | Liver | HCC | 1.78e-08 | 2.75e-01 | 0.2375 |
23510 | KCTD2 | S016 | Human | Liver | HCC | 1.22e-04 | 1.62e-01 | 0.2243 |
23510 | KCTD2 | S027 | Human | Liver | HCC | 3.76e-03 | 2.99e-01 | 0.2446 |
23510 | KCTD2 | S028 | Human | Liver | HCC | 3.42e-07 | 1.90e-01 | 0.2503 |
23510 | KCTD2 | S029 | Human | Liver | HCC | 2.52e-03 | 1.63e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
GO:004316122 | Liver | HCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 299/7958 | 412/18723 | 7.82e-36 | 8.27e-33 | 299 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCTD2 | SNV | Missense_Mutation | novel | c.515N>T | p.Arg172Leu | p.R172L | Q14681 | protein_coding | tolerated(0.07) | benign(0.019) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
KCTD2 | SNV | Missense_Mutation | novel | c.466N>C | p.Glu156Gln | p.E156Q | Q14681 | protein_coding | deleterious(0.02) | possibly_damaging(0.728) | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KCTD2 | SNV | Missense_Mutation | c.249N>G | p.Phe83Leu | p.F83L | Q14681 | protein_coding | tolerated(0.06) | possibly_damaging(0.64) | TCGA-C5-A1MJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
KCTD2 | SNV | Missense_Mutation | rs202181641 | c.481N>A | p.Ala161Thr | p.A161T | Q14681 | protein_coding | tolerated(0.95) | benign(0.028) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
KCTD2 | SNV | Missense_Mutation | c.442N>A | p.Glu148Lys | p.E148K | Q14681 | protein_coding | deleterious(0.04) | possibly_damaging(0.713) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
KCTD2 | SNV | Missense_Mutation | rs763352643 | c.619N>A | p.Gly207Ser | p.G207S | Q14681 | protein_coding | deleterious(0.04) | possibly_damaging(0.656) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KCTD2 | SNV | Missense_Mutation | c.785N>A | p.Arg262Gln | p.R262Q | Q14681 | protein_coding | deleterious(0.03) | probably_damaging(0.94) | TCGA-CK-5915-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KCTD2 | insertion | Frame_Shift_Ins | novel | c.634_635insG | p.Gln212ArgfsTer10 | p.Q212Rfs*10 | Q14681 | protein_coding | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KCTD2 | SNV | Missense_Mutation | novel | c.563N>A | p.Arg188Lys | p.R188K | Q14681 | protein_coding | deleterious(0.01) | possibly_damaging(0.468) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KCTD2 | SNV | Missense_Mutation | novel | c.746N>T | p.Pro249Leu | p.P249L | Q14681 | protein_coding | deleterious(0.04) | benign(0.087) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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