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Gene: KCTD16 |
Gene summary for KCTD16 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | KCTD16 | Gene ID | 57528 |
| Gene name | potassium channel tetramerization domain containing 16 | |
| Gene Alias | KCTD16 | |
| Cytomap | 5q31.3 | |
| Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A8K8W2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57528 | KCTD16 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.79e-02 | 3.07e-01 | -0.1207 |
| 57528 | KCTD16 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.27e-04 | 3.45e-01 | -0.1464 |
| 57528 | KCTD16 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.87e-05 | 2.91e-01 | 0.096 |
| 57528 | KCTD16 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.73e-09 | 2.66e-01 | 0.3005 |
| 57528 | KCTD16 | F007 | Human | Colorectum | FAP | 1.52e-04 | 4.54e-01 | 0.1176 |
| 57528 | KCTD16 | A002-C-010 | Human | Colorectum | FAP | 9.77e-20 | 6.74e-01 | 0.242 |
| 57528 | KCTD16 | A014-C-040 | Human | Colorectum | FAP | 7.44e-03 | 5.66e-01 | -0.1184 |
| 57528 | KCTD16 | A002-C-201 | Human | Colorectum | FAP | 2.53e-02 | 3.31e-01 | 0.0324 |
| 57528 | KCTD16 | A002-C-203 | Human | Colorectum | FAP | 3.64e-06 | 4.25e-01 | 0.2786 |
| 57528 | KCTD16 | A002-C-021 | Human | Colorectum | FAP | 7.06e-31 | 8.68e-01 | 0.1171 |
| 57528 | KCTD16 | A002-C-205 | Human | Colorectum | FAP | 1.77e-03 | 3.64e-01 | -0.1236 |
| 57528 | KCTD16 | A002-C-016 | Human | Colorectum | FAP | 2.84e-07 | 3.92e-01 | 0.0521 |
| 57528 | KCTD16 | A014-C-008 | Human | Colorectum | FAP | 2.10e-12 | 7.31e-01 | -0.191 |
| 57528 | KCTD16 | F034 | Human | Colorectum | FAP | 4.09e-02 | 3.22e-01 | -0.0665 |
| 57528 | KCTD16 | F072B | Human | Colorectum | FAP | 5.99e-24 | 7.83e-01 | 0.257 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| KCTD16 | SNV | Missense_Mutation | c.1052N>G | p.Val351Gly | p.V351G | Q68DU8 | protein_coding | deleterious(0) | benign(0.108) | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
| KCTD16 | insertion | Nonsense_Mutation | novel | c.262_263insGAAAAATACTGGGATAAGAGGAGGTCATTTTTTAATAAGTTAGC | p.Tyr88Ter | p.Y88* | Q68DU8 | protein_coding | TCGA-B6-A0I9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
| KCTD16 | insertion | Frame_Shift_Ins | novel | c.597_598insCA | p.Leu200HisfsTer11 | p.L200Hfs*11 | Q68DU8 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
| KCTD16 | insertion | Nonsense_Mutation | novel | c.599_600insTTGATTTCTTGGGGGAAAAATACT | p.Ser199_Leu200insPheTerPheLeuGlyGlyLysIle | p.S199_L200insF*FLGGKI | Q68DU8 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
| KCTD16 | SNV | Missense_Mutation | novel | c.210G>T | p.Lys70Asn | p.K70N | Q68DU8 | protein_coding | deleterious(0) | possibly_damaging(0.721) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| KCTD16 | SNV | Missense_Mutation | novel | c.1114G>A | p.Gly372Ser | p.G372S | Q68DU8 | protein_coding | tolerated(0.27) | benign(0.009) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| KCTD16 | SNV | Missense_Mutation | c.446N>T | p.Arg149Ile | p.R149I | Q68DU8 | protein_coding | tolerated(0.14) | probably_damaging(0.991) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| KCTD16 | SNV | Missense_Mutation | novel | c.697C>A | p.Leu233Met | p.L233M | Q68DU8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| KCTD16 | SNV | Missense_Mutation | novel | c.656C>A | p.Pro219Gln | p.P219Q | Q68DU8 | protein_coding | deleterious(0) | possibly_damaging(0.77) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| KCTD16 | SNV | Missense_Mutation | novel | c.360N>C | p.Lys120Asn | p.K120N | Q68DU8 | protein_coding | deleterious(0) | possibly_damaging(0.658) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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