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Gene: KCNMB2-AS1 |
Gene summary for KCNMB2-AS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | KCNMB2-AS1 | Gene ID | 104797538 |
Gene name | KCNMB2 antisense RNA 1 | |
Gene Alias | KCNMB2-AS1 | |
Cytomap | 3q26.32 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
104797538 | KCNMB2-AS1 | CCI_1 | Human | Cervix | CC | 5.25e-09 | 5.43e-01 | 0.528 |
104797538 | KCNMB2-AS1 | CCI_3 | Human | Cervix | CC | 3.66e-13 | 5.37e-01 | 0.516 |
104797538 | KCNMB2-AS1 | AEH-subject1 | Human | Endometrium | AEH | 5.97e-26 | 4.79e-01 | -0.3059 |
104797538 | KCNMB2-AS1 | AEH-subject2 | Human | Endometrium | AEH | 2.68e-14 | 3.41e-01 | -0.2525 |
104797538 | KCNMB2-AS1 | AEH-subject3 | Human | Endometrium | AEH | 1.14e-15 | 3.73e-01 | -0.2576 |
104797538 | KCNMB2-AS1 | AEH-subject4 | Human | Endometrium | AEH | 6.00e-24 | 5.39e-01 | -0.2657 |
104797538 | KCNMB2-AS1 | AEH-subject5 | Human | Endometrium | AEH | 3.80e-37 | 6.87e-01 | -0.2953 |
104797538 | KCNMB2-AS1 | EEC-subject1 | Human | Endometrium | EEC | 8.15e-11 | 3.22e-01 | -0.2682 |
104797538 | KCNMB2-AS1 | EEC-subject2 | Human | Endometrium | EEC | 3.02e-19 | 3.61e-01 | -0.2607 |
104797538 | KCNMB2-AS1 | EEC-subject3 | Human | Endometrium | EEC | 8.23e-05 | 2.24e-01 | -0.2525 |
104797538 | KCNMB2-AS1 | EEC-subject4 | Human | Endometrium | EEC | 8.21e-22 | 5.02e-01 | -0.2571 |
104797538 | KCNMB2-AS1 | EEC-subject5 | Human | Endometrium | EEC | 1.58e-12 | 2.92e-01 | -0.249 |
104797538 | KCNMB2-AS1 | GSM5276935 | Human | Endometrium | EEC | 4.07e-08 | 1.55e-01 | -0.123 |
104797538 | KCNMB2-AS1 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.56e-02 | 1.13e-01 | -0.1269 |
104797538 | KCNMB2-AS1 | LZE4T | Human | Esophagus | ESCC | 1.49e-12 | 4.20e-01 | 0.0811 |
104797538 | KCNMB2-AS1 | LZE5T | Human | Esophagus | ESCC | 4.88e-05 | 4.86e-01 | 0.0514 |
104797538 | KCNMB2-AS1 | LZE7T | Human | Esophagus | ESCC | 7.31e-03 | 2.38e-01 | 0.0667 |
104797538 | KCNMB2-AS1 | LZE8T | Human | Esophagus | ESCC | 3.08e-02 | 1.61e-01 | 0.067 |
104797538 | KCNMB2-AS1 | LZE20T | Human | Esophagus | ESCC | 1.76e-02 | 1.24e-01 | 0.0662 |
104797538 | KCNMB2-AS1 | LZE22T | Human | Esophagus | ESCC | 1.22e-05 | 4.61e-01 | 0.068 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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