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Gene: KCNK5 |
Gene summary for KCNK5 |
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Gene information | Species | Human | Gene symbol | KCNK5 | Gene ID | 8645 |
Gene name | potassium two pore domain channel subfamily K member 5 | |
Gene Alias | K2p5.1 | |
Cytomap | 6p21.2 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | A0A024RD32 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8645 | KCNK5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.49e-13 | 6.12e-01 | -0.1808 |
8645 | KCNK5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.47e-03 | 3.16e-01 | -0.0811 |
8645 | KCNK5 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.57e-06 | 2.85e-01 | -0.1954 |
8645 | KCNK5 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.52e-07 | 8.26e-01 | -0.2196 |
8645 | KCNK5 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.10e-07 | 5.71e-01 | -0.1526 |
8645 | KCNK5 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.62e-09 | 4.50e-01 | -0.1464 |
8645 | KCNK5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.49e-06 | 3.44e-01 | -0.059 |
8645 | KCNK5 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.37e-03 | 3.47e-01 | -0.2061 |
8645 | KCNK5 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.18e-02 | 2.11e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCNK5 | SNV | Missense_Mutation | rs368144556 | c.1252N>A | p.Ala418Thr | p.A418T | O95279 | protein_coding | deleterious(0.04) | benign(0.116) | TCGA-A8-A07P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
KCNK5 | SNV | Missense_Mutation | c.329N>G | p.Ala110Gly | p.A110G | O95279 | protein_coding | tolerated(0.35) | benign(0.006) | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
KCNK5 | SNV | Missense_Mutation | novel | c.716N>T | p.Ser239Phe | p.S239F | O95279 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B6-A401-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
KCNK5 | insertion | Frame_Shift_Ins | novel | c.694_695insTGGAAGAGGTGTCACAGACACTGAGGAGCAAAGGC | p.Tyr232LeufsTer27 | p.Y232Lfs*27 | O95279 | protein_coding | TCGA-BH-A0EB-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
KCNK5 | SNV | Missense_Mutation | rs376599617 | c.649N>A | p.Ala217Thr | p.A217T | O95279 | protein_coding | tolerated(0.36) | benign(0.069) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KCNK5 | SNV | Missense_Mutation | c.1085N>C | p.Leu362Pro | p.L362P | O95279 | protein_coding | tolerated(0.07) | possibly_damaging(0.691) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KCNK5 | SNV | Missense_Mutation | c.70N>A | p.Glu24Lys | p.E24K | O95279 | protein_coding | deleterious(0.02) | benign(0.031) | TCGA-AA-3854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KCNK5 | SNV | Missense_Mutation | c.907N>A | p.Asp303Asn | p.D303N | O95279 | protein_coding | deleterious(0.04) | probably_damaging(0.974) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KCNK5 | SNV | Missense_Mutation | c.485N>A | p.Cys162Tyr | p.C162Y | O95279 | protein_coding | deleterious(0.01) | possibly_damaging(0.745) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
KCNK5 | SNV | Missense_Mutation | c.1355N>T | p.Gly452Val | p.G452V | O95279 | protein_coding | tolerated_low_confidence(0.27) | benign(0) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8645 | KCNK5 | ION CHANNEL, DRUGGABLE GENOME | blocker | 135650872 | QUINIDINE | |
8645 | KCNK5 | ION CHANNEL, DRUGGABLE GENOME | activator | 135650346 | HALOTHANE |
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