![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: KCNH6 |
Gene summary for KCNH6 |
![]() |
Gene information | Species | Human | Gene symbol | KCNH6 | Gene ID | 81033 |
Gene name | potassium voltage-gated channel subfamily H member 6 | |
Gene Alias | ERG-2 | |
Cytomap | 17q23.3 | |
Gene Type | protein-coding | GO ID | GO:0002027 | UniProtAcc | B4DKC0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81033 | KCNH6 | HCC1 | Human | Liver | HCC | 7.19e-14 | 1.06e+00 | 0.5336 |
81033 | KCNH6 | HCC2 | Human | Liver | HCC | 2.13e-19 | 1.09e+00 | 0.5341 |
81033 | KCNH6 | HCC5 | Human | Liver | HCC | 8.95e-17 | 9.56e-01 | 0.4932 |
81033 | KCNH6 | S014 | Human | Liver | HCC | 4.27e-19 | 7.24e-01 | 0.2254 |
81033 | KCNH6 | S015 | Human | Liver | HCC | 1.38e-23 | 9.28e-01 | 0.2375 |
81033 | KCNH6 | S016 | Human | Liver | HCC | 7.17e-34 | 1.06e+00 | 0.2243 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCNH6 | SNV | Missense_Mutation | c.2509G>C | p.Glu837Gln | p.E837Q | Q9H252 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
KCNH6 | SNV | Missense_Mutation | c.2052N>C | p.Lys684Asn | p.K684N | Q9H252 | protein_coding | deleterious(0.01) | possibly_damaging(0.893) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD | |
KCNH6 | SNV | Missense_Mutation | novel | c.1390N>T | p.Val464Phe | p.V464F | Q9H252 | protein_coding | deleterious(0) | possibly_damaging(0.876) | TCGA-AN-A049-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KCNH6 | SNV | Missense_Mutation | c.1973G>T | p.Gly658Val | p.G658V | Q9H252 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0XU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KCNH6 | SNV | Missense_Mutation | novel | c.1204T>C | p.Phe402Leu | p.F402L | Q9H252 | protein_coding | tolerated(0.47) | benign(0.048) | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD |
KCNH6 | SNV | Missense_Mutation | c.144N>G | p.Phe48Leu | p.F48L | Q9H252 | protein_coding | deleterious(0.04) | probably_damaging(0.991) | TCGA-D8-A147-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
KCNH6 | SNV | Missense_Mutation | c.1634N>C | p.Leu545Pro | p.L545P | Q9H252 | protein_coding | deleterious(0) | benign(0.017) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KCNH6 | SNV | Missense_Mutation | novel | c.1491N>T | p.Met497Ile | p.M497I | Q9H252 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-PE-A5DC-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
KCNH6 | deletion | Frame_Shift_Del | c.2062delG | p.Ala688GlnfsTer99 | p.A688Qfs*99 | Q9H252 | protein_coding | TCGA-B6-A0RT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |||
KCNH6 | insertion | Frame_Shift_Ins | novel | c.1206_1207insCACACAGCTGCCACAGCGAC | p.Leu403HisfsTer16 | p.L403Hfs*16 | Q9H252 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
81033 | KCNH6 | DRUGGABLE GENOME, ION CHANNEL | inhibitor | 135652149 | ||
81033 | KCNH6 | DRUGGABLE GENOME, ION CHANNEL | blocker | CHEMBL284348 | DALFAMPRIDINE | |
81033 | KCNH6 | DRUGGABLE GENOME, ION CHANNEL | inhibitor | 223366024 | ||
81033 | KCNH6 | DRUGGABLE GENOME, ION CHANNEL | blocker | CHEMBL2107762 | NERISPIRDINE | |
81033 | KCNH6 | DRUGGABLE GENOME, ION CHANNEL | blocker | CHEMBL113461 | TEDISAMIL | |
81033 | KCNH6 | DRUGGABLE GENOME, ION CHANNEL | activator | 135650743 | ||
81033 | KCNH6 | DRUGGABLE GENOME, ION CHANNEL | blocker | CHEMBL1200728 | GUANIDINE HYDROCHLORIDE |
Page: 1 |