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Gene: KCNC3 |
Gene summary for KCNC3 |
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Gene information | Species | Human | Gene symbol | KCNC3 | Gene ID | 3748 |
Gene name | potassium voltage-gated channel subfamily C member 3 | |
Gene Alias | KSHIIID | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q14003 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3748 | KCNC3 | male-WTA | Human | Thyroid | PTC | 5.01e-07 | 1.61e-01 | 0.1037 |
3748 | KCNC3 | PTC04 | Human | Thyroid | PTC | 1.37e-06 | 2.24e-01 | 0.1927 |
3748 | KCNC3 | PTC05 | Human | Thyroid | PTC | 3.24e-09 | 4.34e-01 | 0.2065 |
3748 | KCNC3 | PTC06 | Human | Thyroid | PTC | 3.75e-21 | 5.16e-01 | 0.2057 |
3748 | KCNC3 | PTC07 | Human | Thyroid | PTC | 1.81e-12 | 3.07e-01 | 0.2044 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCNC3 | SNV | Missense_Mutation | novel | c.505G>C | p.Glu169Gln | p.E169Q | Q14003 | protein_coding | deleterious(0.01) | possibly_damaging(0.885) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
KCNC3 | SNV | Missense_Mutation | novel | c.2165N>A | p.Arg722Gln | p.R722Q | Q14003 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.953) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KCNC3 | SNV | Missense_Mutation | novel | c.1544N>T | p.Ser515Leu | p.S515L | Q14003 | protein_coding | tolerated(0.34) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KCNC3 | SNV | Missense_Mutation | novel | c.589N>A | p.Glu197Lys | p.E197K | Q14003 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KCNC3 | SNV | Missense_Mutation | c.293N>A | p.Arg98His | p.R98H | Q14003 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-JW-A69B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
KCNC3 | SNV | Missense_Mutation | novel | c.1275C>G | p.Phe425Leu | p.F425L | Q14003 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-VS-AA62-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
KCNC3 | SNV | Missense_Mutation | novel | c.1945G>T | p.Ala649Ser | p.A649S | Q14003 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.677) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
KCNC3 | SNV | Missense_Mutation | c.1303N>T | p.Arg435Cys | p.R435C | Q14003 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KCNC3 | SNV | Missense_Mutation | novel | c.2054N>C | p.Met685Thr | p.M685T | Q14003 | protein_coding | tolerated_low_confidence(0.13) | benign(0) | TCGA-AA-3521-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KCNC3 | SNV | Missense_Mutation | c.1324N>T | p.Arg442Cys | p.R442C | Q14003 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3748 | KCNC3 | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL113461 | TEDISAMIL | |
3748 | KCNC3 | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL1200728 | GUANIDINE HYDROCHLORIDE | |
3748 | KCNC3 | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL284348 | DALFAMPRIDINE | |
3748 | KCNC3 | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL2107762 | NERISPIRDINE |
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