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Gene: KCNA3 |
Gene summary for KCNA3 |
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Gene information | Species | Human | Gene symbol | KCNA3 | Gene ID | 3738 |
Gene name | potassium voltage-gated channel subfamily A member 3 | |
Gene Alias | HGK5 | |
Cytomap | 1p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | P22001 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3738 | KCNA3 | HCC1 | Human | Liver | HCC | 5.06e-05 | 5.03e-01 | 0.5336 |
3738 | KCNA3 | HCC2 | Human | Liver | HCC | 1.88e-05 | 3.79e-01 | 0.5341 |
3738 | KCNA3 | HCC5 | Human | Liver | HCC | 2.95e-20 | 1.33e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCNA3 | SNV | Missense_Mutation | rs778776863 | c.544N>A | p.Glu182Lys | p.E182K | P22001 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-A2-A0YH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
KCNA3 | SNV | Missense_Mutation | c.974G>A | p.Arg325Gln | p.R325Q | P22001 | protein_coding | deleterious(0) | possibly_damaging(0.503) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KCNA3 | SNV | Missense_Mutation | novel | c.469G>A | p.Asp157Asn | p.D157N | P22001 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KCNA3 | SNV | Missense_Mutation | novel | c.740C>T | p.Ser247Phe | p.S247F | P22001 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KCNA3 | SNV | Missense_Mutation | novel | c.1340N>G | p.Tyr447Cys | p.Y447C | P22001 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
KCNA3 | insertion | Frame_Shift_Ins | novel | c.773_774insTGAT | p.Glu258AspfsTer63 | p.E258Dfs*63 | P22001 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
KCNA3 | SNV | Missense_Mutation | c.1716N>A | p.Phe572Leu | p.F572L | P22001 | protein_coding | tolerated_low_confidence(1) | benign(0.001) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
KCNA3 | SNV | Missense_Mutation | c.1645A>G | p.Thr549Ala | p.T549A | P22001 | protein_coding | tolerated_low_confidence(0.3) | benign(0.001) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KCNA3 | SNV | Missense_Mutation | c.899N>T | p.Thr300Met | p.T300M | P22001 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KCNA3 | SNV | Missense_Mutation | c.1208T>C | p.Phe403Ser | p.F403S | P22001 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3738 | KCNA3 | DRUGGABLE GENOME, ION CHANNEL | blocker | CHEMBL2107762 | NERISPIRDINE | |
3738 | KCNA3 | DRUGGABLE GENOME, ION CHANNEL | blocker | 375973238 | ||
3738 | KCNA3 | DRUGGABLE GENOME, ION CHANNEL | blocker | CHEMBL113461 | TEDISAMIL | |
3738 | KCNA3 | DRUGGABLE GENOME, ION CHANNEL | Debio-0824 | 22637724 | ||
3738 | KCNA3 | DRUGGABLE GENOME, ION CHANNEL | Dalazatide | DALAZATIDE | ||
3738 | KCNA3 | DRUGGABLE GENOME, ION CHANNEL | blocker | 135652058 | ||
3738 | KCNA3 | DRUGGABLE GENOME, ION CHANNEL | blocker | 340590214 | ||
3738 | KCNA3 | DRUGGABLE GENOME, ION CHANNEL | blocker | CHEMBL1200728 | GUANIDINE HYDROCHLORIDE | |
3738 | KCNA3 | DRUGGABLE GENOME, ION CHANNEL | blocker | CHEMBL284348 | DALFAMPRIDINE | |
3738 | KCNA3 | DRUGGABLE GENOME, ION CHANNEL | blocker | 135652678 | CORREOLIDE |
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