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Gene: KC6 |
Gene summary for KC6 |
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Gene information | Species | Human | Gene symbol | KC6 | Gene ID | 641516 |
Gene name | keratoconus gene 6 | |
Gene Alias | KC6 | |
Cytomap | NA | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
641516 | KC6 | P1T-E | Human | Esophagus | ESCC | 1.98e-11 | 4.31e-01 | 0.0875 |
641516 | KC6 | P2T-E | Human | Esophagus | ESCC | 1.61e-32 | 4.96e-01 | 0.1177 |
641516 | KC6 | P4T-E | Human | Esophagus | ESCC | 8.33e-13 | 2.98e-01 | 0.1323 |
641516 | KC6 | P8T-E | Human | Esophagus | ESCC | 3.52e-19 | 2.95e-01 | 0.0889 |
641516 | KC6 | P9T-E | Human | Esophagus | ESCC | 5.22e-18 | 3.68e-01 | 0.1131 |
641516 | KC6 | P10T-E | Human | Esophagus | ESCC | 9.53e-09 | 2.26e-01 | 0.116 |
641516 | KC6 | P12T-E | Human | Esophagus | ESCC | 4.19e-25 | 4.48e-01 | 0.1122 |
641516 | KC6 | P15T-E | Human | Esophagus | ESCC | 2.11e-03 | 1.05e-01 | 0.1149 |
641516 | KC6 | P16T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.22e-01 | 0.1153 |
641516 | KC6 | P20T-E | Human | Esophagus | ESCC | 2.71e-31 | 6.44e-01 | 0.1124 |
641516 | KC6 | P21T-E | Human | Esophagus | ESCC | 1.66e-02 | 9.57e-02 | 0.1617 |
641516 | KC6 | P22T-E | Human | Esophagus | ESCC | 2.86e-20 | 3.43e-01 | 0.1236 |
641516 | KC6 | P23T-E | Human | Esophagus | ESCC | 9.83e-23 | 4.62e-01 | 0.108 |
641516 | KC6 | P24T-E | Human | Esophagus | ESCC | 3.50e-02 | 7.84e-02 | 0.1287 |
641516 | KC6 | P26T-E | Human | Esophagus | ESCC | 3.14e-50 | 7.86e-01 | 0.1276 |
641516 | KC6 | P27T-E | Human | Esophagus | ESCC | 4.19e-25 | 4.11e-01 | 0.1055 |
641516 | KC6 | P28T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.24e-01 | 0.1149 |
641516 | KC6 | P30T-E | Human | Esophagus | ESCC | 1.56e-12 | 3.56e-01 | 0.137 |
641516 | KC6 | P32T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.14e-01 | 0.1666 |
641516 | KC6 | P37T-E | Human | Esophagus | ESCC | 7.83e-07 | 1.59e-01 | 0.1371 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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