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Gene: KATNAL2 |
Gene summary for KATNAL2 |
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Gene information | Species | Human | Gene symbol | KATNAL2 | Gene ID | 83473 |
Gene name | katanin catalytic subunit A1 like 2 | |
Gene Alias | KATNAL2 | |
Cytomap | 18q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8IYT4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83473 | KATNAL2 | NAFLD1 | Human | Liver | NAFLD | 6.35e-04 | 5.11e-01 | -0.04 |
83473 | KATNAL2 | HCC1_Meng | Human | Liver | HCC | 1.25e-07 | -2.49e-02 | 0.0246 |
83473 | KATNAL2 | HCC2 | Human | Liver | HCC | 1.41e-05 | 1.87e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KATNAL2 | SNV | Missense_Mutation | c.790N>T | p.Arg264Trp | p.R264W | Q8IYT4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KATNAL2 | SNV | Missense_Mutation | c.650N>A | p.Gly217Glu | p.G217E | Q8IYT4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B6-A400-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
KATNAL2 | SNV | Missense_Mutation | c.881N>T | p.Ser294Phe | p.S294F | Q8IYT4 | protein_coding | tolerated(0.07) | benign(0.149) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
KATNAL2 | insertion | Nonsense_Mutation | novel | c.771_772insAGCTGAGCAGTCACTTCCTTCCTTGTGTGTGAGACT | p.Gly257_Asp258insSerTerAlaValThrSerPheLeuValCysGluThr | p.G257_D258insS*AVTSFLVCET | Q8IYT4 | protein_coding | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
KATNAL2 | SNV | Missense_Mutation | rs751573875 | c.908G>A | p.Arg303Gln | p.R303Q | Q8IYT4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
KATNAL2 | SNV | Missense_Mutation | c.1390N>A | p.Glu464Lys | p.E464K | Q8IYT4 | protein_coding | tolerated(0.22) | possibly_damaging(0.788) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
KATNAL2 | SNV | Missense_Mutation | c.790N>T | p.Arg264Trp | p.R264W | Q8IYT4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
KATNAL2 | SNV | Missense_Mutation | c.548A>G | p.Asp183Gly | p.D183G | Q8IYT4 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CM-4744-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KATNAL2 | SNV | Missense_Mutation | c.229N>C | p.Asn77His | p.N77H | Q8IYT4 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KATNAL2 | SNV | Missense_Mutation | c.790C>T | p.Arg264Trp | p.R264W | Q8IYT4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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