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Gene: KATNA1 |
Gene summary for KATNA1 |
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Gene information | Species | Human | Gene symbol | KATNA1 | Gene ID | 11104 |
Gene name | katanin catalytic subunit A1 | |
Gene Alias | KATNA1 | |
Cytomap | 6q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | O75449 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11104 | KATNA1 | LZE2T | Human | Esophagus | ESCC | 1.38e-04 | 4.07e-01 | 0.082 |
11104 | KATNA1 | LZE4T | Human | Esophagus | ESCC | 1.42e-10 | 3.08e-01 | 0.0811 |
11104 | KATNA1 | LZE7T | Human | Esophagus | ESCC | 2.56e-02 | 2.10e-01 | 0.0667 |
11104 | KATNA1 | LZE8T | Human | Esophagus | ESCC | 5.64e-07 | 1.36e-01 | 0.067 |
11104 | KATNA1 | LZE22T | Human | Esophagus | ESCC | 1.62e-03 | 3.08e-01 | 0.068 |
11104 | KATNA1 | LZE24T | Human | Esophagus | ESCC | 6.55e-15 | 3.77e-01 | 0.0596 |
11104 | KATNA1 | LZE6T | Human | Esophagus | ESCC | 1.40e-06 | 1.59e-01 | 0.0845 |
11104 | KATNA1 | P1T-E | Human | Esophagus | ESCC | 1.96e-02 | 2.74e-01 | 0.0875 |
11104 | KATNA1 | P2T-E | Human | Esophagus | ESCC | 1.56e-16 | 3.82e-01 | 0.1177 |
11104 | KATNA1 | P4T-E | Human | Esophagus | ESCC | 4.83e-19 | 5.27e-01 | 0.1323 |
11104 | KATNA1 | P5T-E | Human | Esophagus | ESCC | 5.79e-13 | 3.90e-01 | 0.1327 |
11104 | KATNA1 | P8T-E | Human | Esophagus | ESCC | 2.05e-15 | 1.84e-01 | 0.0889 |
11104 | KATNA1 | P9T-E | Human | Esophagus | ESCC | 6.50e-09 | 1.70e-01 | 0.1131 |
11104 | KATNA1 | P10T-E | Human | Esophagus | ESCC | 4.33e-13 | 2.84e-01 | 0.116 |
11104 | KATNA1 | P11T-E | Human | Esophagus | ESCC | 6.41e-06 | 4.66e-01 | 0.1426 |
11104 | KATNA1 | P12T-E | Human | Esophagus | ESCC | 2.14e-18 | 3.46e-01 | 0.1122 |
11104 | KATNA1 | P15T-E | Human | Esophagus | ESCC | 9.08e-22 | 4.88e-01 | 0.1149 |
11104 | KATNA1 | P16T-E | Human | Esophagus | ESCC | 1.93e-29 | 5.46e-01 | 0.1153 |
11104 | KATNA1 | P17T-E | Human | Esophagus | ESCC | 1.23e-08 | 2.51e-01 | 0.1278 |
11104 | KATNA1 | P19T-E | Human | Esophagus | ESCC | 5.61e-06 | 5.90e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KATNA1 | SNV | Missense_Mutation | novel | c.313N>C | p.Glu105Gln | p.E105Q | O75449 | protein_coding | tolerated(0.09) | possibly_damaging(0.864) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
KATNA1 | SNV | Missense_Mutation | c.69N>G | p.Asp23Glu | p.D23E | O75449 | protein_coding | tolerated(0.34) | benign(0.035) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
KATNA1 | insertion | In_Frame_Ins | novel | c.1034_1035insCAAAGCAAGACCCTGTGTCCAAAG | p.Glu345delinsAspLysAlaArgProCysValGlnArg | p.E345delinsDKARPCVQR | O75449 | protein_coding | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
KATNA1 | deletion | Frame_Shift_Del | novel | c.186delN | p.Ala63LeufsTer8 | p.A63Lfs*8 | O75449 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
KATNA1 | SNV | Missense_Mutation | novel | c.562G>C | p.Asp188His | p.D188H | O75449 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
KATNA1 | SNV | Missense_Mutation | c.1165G>A | p.Glu389Lys | p.E389K | O75449 | protein_coding | tolerated(0.14) | benign(0.434) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
KATNA1 | SNV | Missense_Mutation | c.964G>C | p.Glu322Gln | p.E322Q | O75449 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
KATNA1 | SNV | Missense_Mutation | c.769N>A | p.Leu257Ile | p.L257I | O75449 | protein_coding | deleterious(0.01) | possibly_damaging(0.803) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
KATNA1 | SNV | Missense_Mutation | rs748635170 | c.556N>A | p.Gly186Arg | p.G186R | O75449 | protein_coding | deleterious(0) | possibly_damaging(0.888) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KATNA1 | SNV | Missense_Mutation | rs756980278 | c.947N>A | p.Arg316His | p.R316H | O75449 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-D5-5537-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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