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Gene: KANSL1L |
Gene summary for KANSL1L |
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Gene information | Species | Human | Gene symbol | KANSL1L | Gene ID | 151050 |
Gene name | KAT8 regulatory NSL complex subunit 1 like | |
Gene Alias | C2orf67 | |
Cytomap | 2q34 | |
Gene Type | protein-coding | GO ID | GO:0000123 | UniProtAcc | A0AUZ9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
151050 | KANSL1L | RNA-P17T-P17T-2 | Human | Lung | IAC | 9.09e-03 | 5.26e-01 | 0.3371 |
151050 | KANSL1L | RNA-P17T-P17T-4 | Human | Lung | IAC | 9.41e-06 | 7.58e-01 | 0.343 |
151050 | KANSL1L | RNA-P17T-P17T-6 | Human | Lung | IAC | 1.60e-04 | 6.34e-01 | 0.3385 |
151050 | KANSL1L | RNA-P17T-P17T-8 | Human | Lung | IAC | 4.85e-04 | 4.72e-01 | 0.3329 |
151050 | KANSL1L | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 6.19e-21 | 8.33e-01 | -0.2116 |
151050 | KANSL1L | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 3.74e-07 | 7.72e-01 | -0.1941 |
151050 | KANSL1L | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 8.99e-05 | 6.52e-01 | -0.2107 |
151050 | KANSL1L | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 8.84e-14 | 7.68e-01 | -0.2119 |
151050 | KANSL1L | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.02e-06 | 3.24e-01 | -0.0166 |
151050 | KANSL1L | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 6.28e-11 | 3.83e-01 | -0.0132 |
151050 | KANSL1L | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 5.62e-10 | 3.56e-01 | -0.013 |
151050 | KANSL1L | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.59e-05 | 3.10e-01 | -0.0121 |
151050 | KANSL1L | HTA12-18-3 | Human | Pancreas | PDAC | 1.93e-10 | 1.13e+00 | 0.0716 |
151050 | KANSL1L | HTA12-23-1 | Human | Pancreas | PDAC | 1.43e-05 | 7.49e-01 | 0.3405 |
151050 | KANSL1L | HTA12-25-1 | Human | Pancreas | PDAC | 2.17e-03 | 5.12e-01 | 0.313 |
151050 | KANSL1L | HTA12-26-1 | Human | Pancreas | PDAC | 1.52e-14 | 7.98e-01 | 0.3728 |
151050 | KANSL1L | HTA12-29-1 | Human | Pancreas | PDAC | 4.88e-28 | 7.37e-01 | 0.3722 |
151050 | KANSL1L | HTA12-9-2 | Human | Pancreas | PDAC | 2.96e-02 | 4.63e-01 | 0.0835 |
151050 | KANSL1L | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 1.80e-06 | 2.92e-01 | -0.23 |
151050 | KANSL1L | 047563_1562-all-cells | Human | Prostate | BPH | 3.82e-03 | 3.12e-01 | 0.0791 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KANSL1L | SNV | Missense_Mutation | novel | c.32A>G | p.Lys11Arg | p.K11R | A0AUZ9 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-A8-A08P-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
KANSL1L | SNV | Missense_Mutation | c.2162N>T | p.Arg721Ile | p.R721I | A0AUZ9 | protein_coding | tolerated(0.08) | possibly_damaging(0.735) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KANSL1L | SNV | Missense_Mutation | novel | c.1073N>T | p.Arg358Ile | p.R358I | A0AUZ9 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KANSL1L | SNV | Missense_Mutation | novel | c.707N>A | p.Ser236Asn | p.S236N | A0AUZ9 | protein_coding | tolerated(0.26) | probably_damaging(0.986) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KANSL1L | SNV | Missense_Mutation | novel | c.2848G>A | p.Glu950Lys | p.E950K | A0AUZ9 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.54) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD |
KANSL1L | insertion | Frame_Shift_Ins | novel | c.1961_1962insA | p.Thr655AspfsTer2 | p.T655Dfs*2 | A0AUZ9 | protein_coding | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
KANSL1L | SNV | Missense_Mutation | novel | c.2413N>G | p.Leu805Val | p.L805V | A0AUZ9 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-C5-A1BI-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
KANSL1L | SNV | Missense_Mutation | novel | c.1603N>A | p.Gln535Lys | p.Q535K | A0AUZ9 | protein_coding | deleterious(0.02) | probably_damaging(0.968) | TCGA-C5-A8ZZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | SD |
KANSL1L | SNV | Missense_Mutation | rs762505094 | c.1420G>A | p.Glu474Lys | p.E474K | A0AUZ9 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
KANSL1L | SNV | Missense_Mutation | c.1560N>T | p.Glu520Asp | p.E520D | A0AUZ9 | protein_coding | tolerated(0.49) | probably_damaging(0.987) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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