Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: KANSL1

Gene summary for KANSL1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

KANSL1

Gene ID

284058

Gene nameKAT8 regulatory NSL complex subunit 1
Gene AliasCENP-36
Cytomap17q21.31
Gene Typeprotein-coding
GO ID

GO:0006464

UniProtAcc

Q7Z3B3


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
284058KANSL1CA_HPV_1HumanCervixCC1.60e-024.73e-020.0264
284058KANSL1CA_HPV_3HumanCervixCC2.15e-031.17e-010.0414
284058KANSL1CCI_1HumanCervixCC7.36e-171.32e+000.528
284058KANSL1CCI_2HumanCervixCC4.96e-101.56e+000.5249
284058KANSL1CCI_3HumanCervixCC7.07e-171.15e+000.516
284058KANSL1HTA11_3410_2000001011HumanColorectumAD1.45e-43-8.37e-010.0155
284058KANSL1HTA11_2487_2000001011HumanColorectumSER3.18e-04-4.12e-01-0.1808
284058KANSL1HTA11_2951_2000001011HumanColorectumAD5.97e-03-4.74e-010.0216
284058KANSL1HTA11_347_2000001011HumanColorectumAD3.63e-043.95e-01-0.1954
284058KANSL1HTA11_2112_2000001011HumanColorectumSER5.84e-043.65e-01-0.2196
284058KANSL1HTA11_696_2000001011HumanColorectumAD2.17e-02-3.14e-01-0.1464
284058KANSL1HTA11_2992_2000001011HumanColorectumSER2.45e-04-4.03e-01-0.1706
284058KANSL1HTA11_5212_2000001011HumanColorectumAD7.95e-12-7.62e-01-0.2061
284058KANSL1HTA11_5216_2000001011HumanColorectumSER5.14e-03-4.74e-01-0.1462
284058KANSL1HTA11_7862_2000001011HumanColorectumAD8.68e-05-4.86e-01-0.0179
284058KANSL1HTA11_8622_2000001021HumanColorectumSER3.92e-08-5.12e-010.0528
284058KANSL1HTA11_11156_2000001011HumanColorectumAD3.02e-02-6.64e-010.0397
284058KANSL1HTA11_99999970781_79442HumanColorectumMSS9.63e-09-3.83e-010.294
284058KANSL1HTA11_99999965062_69753HumanColorectumMSI-H3.86e-025.97e-010.3487
284058KANSL1F007HumanColorectumFAP4.50e-041.31e-010.1176
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00165705CervixCChistone modification84/2311463/187231.70e-042.01e-0384
GO:00182054CervixCCpeptidyl-lysine modification62/2311376/187231.04e-024.97e-0262
GO:0016570ColorectumMSShistone modification113/3467463/187238.37e-048.68e-03113
GO:00165701ColorectumFAPhistone modification94/2622463/187231.06e-041.76e-0394
GO:00165702ColorectumCRChistone modification75/2078463/187234.95e-047.06e-0375
GO:00182057EsophagusHGINpeptidyl-lysine modification88/2587376/187232.99e-071.39e-0588
GO:00165708EsophagusHGINhistone modification92/2587463/187231.70e-043.30e-0392
GO:00064735EsophagusHGINprotein acetylation45/2587201/187236.17e-048.58e-0345
GO:00439844EsophagusHGINhistone H4-K16 acetylation9/258720/187237.18e-049.60e-039
GO:00183945EsophagusHGINpeptidyl-lysine acetylation39/2587169/187237.46e-049.90e-0339
GO:00435435EsophagusHGINprotein acylation51/2587243/187231.33e-031.57e-0251
GO:00439675EsophagusHGINhistone H4 acetylation19/258767/187231.39e-031.63e-0219
GO:00064755EsophagusHGINinternal protein amino acid acetylation36/2587160/187231.87e-032.01e-0236
GO:00183935EsophagusHGINinternal peptidyl-lysine acetylation35/2587158/187232.82e-032.75e-0235
GO:001657015EsophagusESCChistone modification323/8552463/187232.61e-267.88e-24323
GO:001820514EsophagusESCCpeptidyl-lysine modification259/8552376/187233.90e-205.26e-18259
GO:001839413EsophagusESCCpeptidyl-lysine acetylation123/8552169/187236.58e-132.94e-11123
GO:004354313EsophagusESCCprotein acylation165/8552243/187231.69e-127.14e-11165
GO:000647313EsophagusESCCprotein acetylation140/8552201/187234.37e-121.69e-10140
GO:001839313EsophagusESCCinternal peptidyl-lysine acetylation114/8552158/187231.16e-114.24e-10114
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
KANSL1SNVMissense_Mutationrs369793673c.103N>Ap.Glu35Lysp.E35KQ7Z3B3protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KANSL1SNVMissense_Mutationnovelc.1527N>Ap.Asp509Glup.D509EQ7Z3B3protein_codingtolerated(0.62)benign(0.017)TCGA-BH-A18L-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
KANSL1SNVMissense_Mutationrs779806189c.2660C>Tp.Thr887Metp.T887MQ7Z3B3protein_codingdeleterious(0)probably_damaging(0.999)TCGA-OL-A6VQ-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
KANSL1SNVMissense_Mutationnovelc.2358N>Ap.Met786Ilep.M786IQ7Z3B3protein_codingdeleterious(0.03)benign(0.037)TCGA-PE-A5DE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
KANSL1insertionIn_Frame_Insnovelc.3091_3092insGGAGATATATGGAACTAGTGGAGATATATGGAAp.Ser1031delinsTrpArgTyrMetGluLeuValGluIleTyrGlyThrp.S1031delinsWRYMELVEIYGTQ7Z3B3protein_codingTCGA-A8-A07G-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapy5-fluorouracilCR
KANSL1deletionFrame_Shift_Delc.2902delNp.Gln968SerfsTer46p.Q968Sfs*46Q7Z3B3protein_codingTCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KANSL1insertionFrame_Shift_Insnovelc.2277_2278insAACCAGTTTTATTCTCATCACCTGCTCTCTATCTCTGGCTCTAAATp.Val760AsnfsTer36p.V760Nfs*36Q7Z3B3protein_codingTCGA-AN-A0FN-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
KANSL1deletionFrame_Shift_Delnovelc.1710delNp.Gln570HisfsTer8p.Q570Hfs*8Q7Z3B3protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
KANSL1SNVMissense_Mutationnovelc.2201N>Tp.Ala734Valp.A734VQ7Z3B3protein_codingtolerated(0.27)benign(0.148)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
KANSL1SNVMissense_Mutationrs775472991c.31N>Ap.Ala11Thrp.A11TQ7Z3B3protein_codingdeleterious(0)probably_damaging(0.977)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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