Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: KANK4

Gene summary for KANK4

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

KANK4

Gene ID

163782

Gene nameKN motif and ankyrin repeat domains 4
Gene AliasANKRD38
Cytomap1p31.3
Gene Typeprotein-coding
GO ID

GO:0006996

UniProtAcc

Q5T7N3


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
163782KANK4HCC1HumanLiverHCC1.95e-112.42e+000.5336
163782KANK4HCC2HumanLiverHCC1.14e-241.89e+000.5341
163782KANK4HCC5HumanLiverHCC2.18e-151.17e+000.4932
163782KANK4S014HumanLiverHCC5.58e-062.24e-010.2254
163782KANK4S015HumanLiverHCC5.13e-042.59e-010.2375
163782KANK4S016HumanLiverHCC1.76e-041.96e-010.2243
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:004325422LiverHCCregulation of protein-containing complex assembly264/7958428/187235.47e-164.39e-14264
GO:005125822LiverHCCprotein polymerization182/7958297/187234.17e-111.58e-09182
GO:190290322LiverHCCregulation of supramolecular fiber organization224/7958383/187231.54e-105.33e-09224
GO:000701522LiverHCCactin filament organization252/7958442/187233.83e-101.25e-08252
GO:001063912LiverHCCnegative regulation of organelle organization204/7958348/187237.67e-102.37e-08204
GO:003253522LiverHCCregulation of cellular component size217/7958383/187231.28e-083.14e-07217
GO:003227122LiverHCCregulation of protein polymerization141/7958233/187232.00e-084.72e-07141
GO:003297022LiverHCCregulation of actin filament-based process222/7958397/187233.81e-088.30e-07222
GO:003295622LiverHCCregulation of actin cytoskeleton organization202/7958358/187236.18e-081.29e-06202
GO:003133312LiverHCCnegative regulation of protein-containing complex assembly91/7958141/187231.01e-071.98e-0691
GO:000815422LiverHCCactin polymerization or depolymerization130/7958218/187232.31e-074.14e-06130
GO:003004122LiverHCCactin filament polymerization116/7958191/187232.66e-074.68e-06116
GO:011005322LiverHCCregulation of actin filament organization158/7958278/187239.01e-071.37e-05158
GO:003083212LiverHCCregulation of actin filament length113/7958189/187231.16e-061.71e-05113
GO:003083322LiverHCCregulation of actin filament polymerization104/7958172/187231.46e-062.08e-05104
GO:000806412LiverHCCregulation of actin polymerization or depolymerization112/7958188/187231.65e-062.31e-05112
GO:190290412LiverHCCnegative regulation of supramolecular fiber organization90/7958167/187231.90e-039.69e-0390
GO:003227212LiverHCCnegative regulation of protein polymerization46/795880/187234.81e-032.03e-0246
GO:00514946LiverHCCnegative regulation of cytoskeleton organization84/7958163/187231.22e-024.43e-0284
GO:003083712LiverHCCnegative regulation of actin filament polymerization37/795865/187231.33e-024.77e-0237
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
KANK4SNVMissense_Mutationrs367566584c.59N>Tp.Pro20Leup.P20LQ5T7N3protein_codingdeleterious(0.02)probably_damaging(0.909)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KANK4SNVMissense_Mutationc.2099A>Gp.Asp700Glyp.D700GQ5T7N3protein_codingtolerated(0.2)benign(0.005)TCGA-B6-A0I9-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownPD
KANK4SNVMissense_Mutationrs745408659c.1897G>Ap.Val633Metp.V633MQ5T7N3protein_codingtolerated(0.35)benign(0)TCGA-BH-A0HK-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
KANK4SNVMissense_Mutationc.2032N>Ap.Glu678Lysp.E678KQ5T7N3protein_codingdeleterious(0)probably_damaging(0.965)TCGA-D8-A27G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KANK4insertionNonsense_Mutationnovelc.560_561insAAGATCATTCTAACCTGTGAp.Pro188ArgfsTer4p.P188Rfs*4Q5T7N3protein_codingTCGA-A8-A06X-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KANK4insertionFrame_Shift_Insnovelc.1935_1936insTTTGATTTAGAATATTTTCTAAATCAGTCATTCAACAAACp.Lys646PhefsTer25p.K646Ffs*25Q5T7N3protein_codingTCGA-BH-A0HF-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
KANK4SNVMissense_Mutationrs150098757c.1234G>Ap.Val412Metp.V412MQ5T7N3protein_codingdeleterious(0)benign(0.057)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
KANK4SNVMissense_Mutationrs201256809c.656G>Ap.Arg219Glnp.R219QQ5T7N3protein_codingtolerated(0.96)benign(0)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
KANK4SNVMissense_Mutationrs371348159c.910N>Ap.Glu304Lysp.E304KQ5T7N3protein_codingdeleterious(0.03)possibly_damaging(0.886)TCGA-C5-A1BL-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
KANK4SNVMissense_Mutationnovelc.2164N>Ap.Glu722Lysp.E722KQ5T7N3protein_codingtolerated(0.12)benign(0.003)TCGA-ZJ-AAXJ-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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