Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: KAL1

Gene summary for KAL1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

KAL1

Gene ID

3730

Gene nameanosmin 1
Gene AliasADMLX
CytomapXp22.31
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

P23352


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
3730KAL1GSM5353216_PA_PB1A_Pool_1_3_S50_L002HumanProstateTumor1.29e-046.02e-010.159
3730KAL1GSM5353221_PA_PB2A_Pool_1_3_S25_L001HumanProstateTumor2.76e-073.41e-010.1633
3730KAL1GSM5353222_PA_PB2B_Pool_1_3_S52_L002HumanProstateTumor6.05e-062.98e-010.1608
3730KAL1GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001HumanProstateTumor1.14e-042.66e-010.1621
3730KAL1GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002HumanProstateTumor3.50e-022.93e-010.1619
3730KAL1GSM5353236_PA_PR5251_T1_S7_L001HumanProstateTumor4.89e-095.20e-010.1608
3730KAL1GSM5353237_PA_PR5251_T2_S8_L001HumanProstateTumor2.03e-107.36e-010.1622
3730KAL1GSM5353244_PA_PR5261_T2_S24_L002HumanProstateTumor5.54e-032.33e-010.1569
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0034470ColorectumMSI-HncRNA processing48/1319395/187231.54e-044.47e-0348
GO:0034660ColorectumMSI-HncRNA metabolic process53/1319485/187239.66e-041.68e-0253
GO:00344707EndometriumAEHncRNA processing62/2100395/187233.93e-032.65e-0262
GO:003447012EndometriumEECncRNA processing63/2168395/187235.20e-033.26e-0263
GO:003447015EsophagusESCCncRNA processing300/8552395/187233.09e-353.26e-32300
GO:003466012EsophagusESCCncRNA metabolic process346/8552485/187234.35e-312.51e-28346
GO:00080333EsophagusESCCtRNA processing92/8552127/187237.83e-101.93e-0892
GO:00063992EsophagusESCCtRNA metabolic process122/8552179/187239.03e-102.19e-08122
GO:00094512EsophagusESCCRNA modification114/8552167/187232.76e-096.04e-08114
GO:00064002EsophagusESCCtRNA modification62/855290/187237.02e-067.04e-0562
GO:00344704LiverNAFLDncRNA processing57/1882395/187233.34e-032.93e-0257
GO:00344701LiverCirrhoticncRNA processing158/4634395/187231.09e-116.96e-10158
GO:00346603LiverCirrhoticncRNA metabolic process173/4634485/187233.64e-081.21e-06173
GO:00344702LiverHCCncRNA processing293/7958395/187234.26e-386.76e-35293
GO:00346601LiverHCCncRNA metabolic process332/7958485/187231.48e-317.80e-29332
GO:0008033LiverHCCtRNA processing87/7958127/187232.66e-097.23e-0887
GO:0006399LiverHCCtRNA metabolic process108/7958179/187231.07e-061.59e-05108
GO:0009451LiverHCCRNA modification101/7958167/187232.02e-062.78e-05101
GO:0006400LiverHCCtRNA modification60/795890/187233.09e-064.09e-0560
GO:00344709Oral cavityOSCCncRNA processing263/7305395/187234.38e-292.78e-26263
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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