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Gene: JRKL |
Gene summary for JRKL |
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Gene information | Species | Human | Gene symbol | JRKL | Gene ID | 8690 |
Gene name | JRK like | |
Gene Alias | HHMJG | |
Cytomap | 11q21 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q9Y4A0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8690 | JRKL | HCC1 | Human | Liver | HCC | 3.35e-03 | 2.23e+00 | 0.5336 |
8690 | JRKL | HCC2 | Human | Liver | HCC | 7.10e-03 | 1.54e+00 | 0.5341 |
8690 | JRKL | S029 | Human | Liver | HCC | 7.26e-03 | 1.47e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
JRKL | SNV | Missense_Mutation | rs781678964 | c.998N>T | p.Thr333Met | p.T333M | Q9Y4A0 | protein_coding | tolerated(0.07) | benign(0.274) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
JRKL | SNV | Missense_Mutation | novel | c.153N>T | p.Lys51Asn | p.K51N | Q9Y4A0 | protein_coding | deleterious(0.02) | possibly_damaging(0.583) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
JRKL | SNV | Missense_Mutation | novel | c.261C>G | p.Phe87Leu | p.F87L | Q9Y4A0 | protein_coding | deleterious(0.01) | possibly_damaging(0.892) | TCGA-C5-A1M7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
JRKL | SNV | Missense_Mutation | c.511N>A | p.Glu171Lys | p.E171K | Q9Y4A0 | protein_coding | deleterious(0.01) | probably_damaging(0.925) | TCGA-FU-A770-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
JRKL | SNV | Missense_Mutation | novel | c.1498C>G | p.Leu500Val | p.L500V | Q9Y4A0 | protein_coding | deleterious(0.03) | benign(0.401) | TCGA-VS-A9UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
JRKL | SNV | Missense_Mutation | c.229N>A | p.Glu77Lys | p.E77K | Q9Y4A0 | protein_coding | tolerated(0.26) | benign(0.191) | TCGA-ZJ-AAXN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
JRKL | SNV | Missense_Mutation | c.481N>T | p.Asp161Tyr | p.D161Y | Q9Y4A0 | protein_coding | deleterious(0.02) | benign(0.133) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
JRKL | SNV | Missense_Mutation | c.803N>C | p.Lys268Thr | p.K268T | Q9Y4A0 | protein_coding | deleterious(0.05) | possibly_damaging(0.723) | TCGA-AA-3673-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
JRKL | SNV | Missense_Mutation | rs745956441 | c.1438G>A | p.Ala480Thr | p.A480T | Q9Y4A0 | protein_coding | tolerated(0.09) | benign(0.005) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
JRKL | SNV | Missense_Mutation | novel | c.1286A>T | p.Glu429Val | p.E429V | Q9Y4A0 | protein_coding | tolerated(0.09) | possibly_damaging(0.794) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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