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Gene: JRK |
Gene summary for JRK |
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Gene information | Species | Human | Gene symbol | JRK | Gene ID | 8629 |
Gene name | Jrk helix-turn-helix protein | |
Gene Alias | JH8 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | D3DWI5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8629 | JRK | HCC1_Meng | Human | Liver | HCC | 2.08e-31 | 4.48e-02 | 0.0246 |
8629 | JRK | HCC2_Meng | Human | Liver | HCC | 1.72e-17 | 1.05e-01 | 0.0107 |
8629 | JRK | HCC2 | Human | Liver | HCC | 1.62e-04 | 1.66e+00 | 0.5341 |
8629 | JRK | S014 | Human | Liver | HCC | 2.73e-13 | 5.36e-01 | 0.2254 |
8629 | JRK | S015 | Human | Liver | HCC | 3.14e-14 | 6.06e-01 | 0.2375 |
8629 | JRK | S016 | Human | Liver | HCC | 1.61e-15 | 4.56e-01 | 0.2243 |
8629 | JRK | S028 | Human | Liver | HCC | 5.51e-06 | 2.70e-01 | 0.2503 |
8629 | JRK | S029 | Human | Liver | HCC | 6.45e-09 | 2.75e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:019873821 | Liver | HCC | cell-cell signaling by wnt | 247/7958 | 446/18723 | 2.11e-08 | 4.96e-07 | 247 |
GO:001605521 | Liver | HCC | Wnt signaling pathway | 245/7958 | 444/18723 | 3.68e-08 | 8.09e-07 | 245 |
GO:003011121 | Liver | HCC | regulation of Wnt signaling pathway | 180/7958 | 328/18723 | 3.62e-06 | 4.72e-05 | 180 |
GO:006007021 | Liver | HCC | canonical Wnt signaling pathway | 162/7958 | 303/18723 | 7.00e-05 | 6.32e-04 | 162 |
GO:006082821 | Liver | HCC | regulation of canonical Wnt signaling pathway | 137/7958 | 253/18723 | 1.15e-04 | 9.70e-04 | 137 |
GO:003017721 | Liver | HCC | positive regulation of Wnt signaling pathway | 81/7958 | 140/18723 | 1.73e-04 | 1.36e-03 | 81 |
GO:009026321 | Liver | HCC | positive regulation of canonical Wnt signaling pathway | 62/7958 | 106/18723 | 6.44e-04 | 3.99e-03 | 62 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
JRK | SNV | Missense_Mutation | novel | c.1190N>G | p.Ser397Cys | p.S397C | protein_coding | tolerated(0.19) | benign(0.439) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
JRK | SNV | Missense_Mutation | novel | c.495C>G | p.Phe165Leu | p.F165L | protein_coding | deleterious(0.01) | benign(0.219) | TCGA-5M-AAT4-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
JRK | SNV | Missense_Mutation | rs375018716 | c.1129G>A | p.Val377Ile | p.V377I | protein_coding | tolerated(0.34) | benign(0.005) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
JRK | SNV | Missense_Mutation | novel | c.796N>T | p.Ile266Phe | p.I266F | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
JRK | SNV | Missense_Mutation | rs782134634 | c.718N>A | p.Gly240Ser | p.G240S | protein_coding | tolerated(0.59) | benign(0.009) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
JRK | SNV | Missense_Mutation | novel | c.1445N>A | p.Gly482Asp | p.G482D | protein_coding | tolerated(0.47) | benign(0) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
JRK | SNV | Missense_Mutation | novel | c.431N>A | p.Gly144Asp | p.G144D | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
JRK | SNV | Missense_Mutation | rs782654867 | c.1169N>T | p.Ala390Val | p.A390V | protein_coding | tolerated(1) | benign(0) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
JRK | SNV | Missense_Mutation | novel | c.914C>T | p.Pro305Leu | p.P305L | protein_coding | tolerated(0.05) | possibly_damaging(0.881) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
JRK | SNV | Missense_Mutation | rs782289704 | c.1114N>A | p.Ala372Thr | p.A372T | protein_coding | tolerated(0.57) | benign(0) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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