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Gene: JPX |
Gene summary for JPX |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | JPX | Gene ID | 554203 |
| Gene name | JPX transcript, XIST activator | |
| Gene Alias | DCBALD06 | |
| Cytomap | Xq13.2 | |
| Gene Type | ncRNA | GO ID | GO:0008150 | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 554203 | JPX | CCI_1 | Human | Cervix | CC | 2.39e-20 | 9.37e-01 | 0.528 |
| 554203 | JPX | CCI_2 | Human | Cervix | CC | 2.30e-24 | 1.30e+00 | 0.5249 |
| 554203 | JPX | CCI_3 | Human | Cervix | CC | 2.29e-28 | 9.92e-01 | 0.516 |
| 554203 | JPX | CCII_1 | Human | Cervix | CC | 9.25e-04 | 1.72e-01 | 0.3249 |
| 554203 | JPX | Tumor | Human | Cervix | CC | 4.02e-10 | 2.01e-01 | 0.1241 |
| 554203 | JPX | sample1 | Human | Cervix | CC | 1.12e-16 | 4.79e-01 | 0.0959 |
| 554203 | JPX | sample3 | Human | Cervix | CC | 3.29e-32 | 4.56e-01 | 0.1387 |
| 554203 | JPX | H2 | Human | Cervix | HSIL_HPV | 4.34e-27 | 4.28e-01 | 0.0632 |
| 554203 | JPX | L1 | Human | Cervix | CC | 1.52e-10 | 4.18e-01 | 0.0802 |
| 554203 | JPX | T1 | Human | Cervix | CC | 2.33e-22 | 4.18e-01 | 0.0918 |
| 554203 | JPX | T2 | Human | Cervix | CC | 1.63e-12 | 4.06e-01 | 0.0709 |
| 554203 | JPX | T3 | Human | Cervix | CC | 4.67e-35 | 4.74e-01 | 0.1389 |
| 554203 | JPX | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.05e-37 | -8.61e-01 | 0.0155 |
| 554203 | JPX | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.23e-22 | -8.60e-01 | -0.1808 |
| 554203 | JPX | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.07e-04 | -8.33e-01 | 0.0216 |
| 554203 | JPX | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.01e-08 | -6.46e-01 | -0.0811 |
| 554203 | JPX | HTA11_78_2000001011 | Human | Colorectum | AD | 6.09e-15 | -6.95e-01 | -0.1088 |
| 554203 | JPX | HTA11_347_2000001011 | Human | Colorectum | AD | 1.32e-07 | -3.89e-01 | -0.1954 |
| 554203 | JPX | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.99e-03 | -7.90e-01 | -0.2196 |
| 554203 | JPX | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.13e-16 | -8.38e-01 | -0.1207 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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