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Gene: JKAMP |
Gene summary for JKAMP |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | JKAMP | Gene ID | 51528 |
| Gene name | JNK1/MAPK8 associated membrane protein | |
| Gene Alias | C14orf100 | |
| Cytomap | 14q23.1 | |
| Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9P055 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 51528 | JKAMP | LZE4T | Human | Esophagus | ESCC | 2.51e-17 | 5.78e-01 | 0.0811 |
| 51528 | JKAMP | LZE8T | Human | Esophagus | ESCC | 2.03e-11 | 4.79e-01 | 0.067 |
| 51528 | JKAMP | LZE20T | Human | Esophagus | ESCC | 1.03e-04 | 3.42e-01 | 0.0662 |
| 51528 | JKAMP | LZE22T | Human | Esophagus | ESCC | 3.75e-06 | 5.64e-01 | 0.068 |
| 51528 | JKAMP | LZE24T | Human | Esophagus | ESCC | 4.17e-14 | 4.40e-01 | 0.0596 |
| 51528 | JKAMP | LZE6T | Human | Esophagus | ESCC | 5.92e-03 | 3.20e-01 | 0.0845 |
| 51528 | JKAMP | P2T-E | Human | Esophagus | ESCC | 9.33e-29 | 4.32e-01 | 0.1177 |
| 51528 | JKAMP | P4T-E | Human | Esophagus | ESCC | 8.34e-17 | 5.08e-01 | 0.1323 |
| 51528 | JKAMP | P5T-E | Human | Esophagus | ESCC | 4.37e-19 | 4.36e-01 | 0.1327 |
| 51528 | JKAMP | P8T-E | Human | Esophagus | ESCC | 5.07e-32 | 6.37e-01 | 0.0889 |
| 51528 | JKAMP | P9T-E | Human | Esophagus | ESCC | 1.48e-08 | 2.71e-01 | 0.1131 |
| 51528 | JKAMP | P10T-E | Human | Esophagus | ESCC | 3.57e-25 | 4.85e-01 | 0.116 |
| 51528 | JKAMP | P11T-E | Human | Esophagus | ESCC | 2.17e-22 | 9.11e-01 | 0.1426 |
| 51528 | JKAMP | P12T-E | Human | Esophagus | ESCC | 2.53e-44 | 7.62e-01 | 0.1122 |
| 51528 | JKAMP | P15T-E | Human | Esophagus | ESCC | 1.25e-45 | 1.02e+00 | 0.1149 |
| 51528 | JKAMP | P16T-E | Human | Esophagus | ESCC | 1.31e-24 | 4.37e-01 | 0.1153 |
| 51528 | JKAMP | P17T-E | Human | Esophagus | ESCC | 1.31e-06 | 4.29e-01 | 0.1278 |
| 51528 | JKAMP | P19T-E | Human | Esophagus | ESCC | 8.70e-13 | 8.09e-01 | 0.1662 |
| 51528 | JKAMP | P20T-E | Human | Esophagus | ESCC | 7.19e-21 | 4.72e-01 | 0.1124 |
| 51528 | JKAMP | P21T-E | Human | Esophagus | ESCC | 8.59e-41 | 7.57e-01 | 0.1617 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
| GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
| GO:0034976111 | Esophagus | ESCC | response to endoplasmic reticulum stress | 192/8552 | 256/18723 | 7.15e-22 | 1.30e-19 | 192 |
| GO:0035966111 | Esophagus | ESCC | response to topologically incorrect protein | 125/8552 | 159/18723 | 1.44e-17 | 1.27e-15 | 125 |
| GO:0006986111 | Esophagus | ESCC | response to unfolded protein | 107/8552 | 137/18723 | 7.01e-15 | 3.87e-13 | 107 |
| GO:003650315 | Esophagus | ESCC | ERAD pathway | 82/8552 | 107/18723 | 5.80e-11 | 1.84e-09 | 82 |
| GO:003043314 | Esophagus | ESCC | ubiquitin-dependent ERAD pathway | 66/8552 | 85/18723 | 1.64e-09 | 3.78e-08 | 66 |
| GO:001049812 | Liver | Cirrhotic | proteasomal protein catabolic process | 216/4634 | 490/18723 | 2.52e-21 | 9.29e-19 | 216 |
| GO:00349767 | Liver | Cirrhotic | response to endoplasmic reticulum stress | 130/4634 | 256/18723 | 1.72e-19 | 3.86e-17 | 130 |
| GO:004316112 | Liver | Cirrhotic | proteasome-mediated ubiquitin-dependent protein catabolic process | 184/4634 | 412/18723 | 4.52e-19 | 8.85e-17 | 184 |
| GO:00359667 | Liver | Cirrhotic | response to topologically incorrect protein | 91/4634 | 159/18723 | 2.07e-18 | 3.60e-16 | 91 |
| GO:00069867 | Liver | Cirrhotic | response to unfolded protein | 79/4634 | 137/18723 | 1.99e-16 | 2.49e-14 | 79 |
| GO:0030433 | Liver | Cirrhotic | ubiquitin-dependent ERAD pathway | 45/4634 | 85/18723 | 2.19e-08 | 7.75e-07 | 45 |
| GO:00365032 | Liver | Cirrhotic | ERAD pathway | 53/4634 | 107/18723 | 2.58e-08 | 8.89e-07 | 53 |
| GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
| GO:004316122 | Liver | HCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 299/7958 | 412/18723 | 7.82e-36 | 8.27e-33 | 299 |
| GO:003497612 | Liver | HCC | response to endoplasmic reticulum stress | 189/7958 | 256/18723 | 1.43e-24 | 4.06e-22 | 189 |
| GO:003596612 | Liver | HCC | response to topologically incorrect protein | 123/7958 | 159/18723 | 2.60e-19 | 3.44e-17 | 123 |
| GO:003650311 | Liver | HCC | ERAD pathway | 88/7958 | 107/18723 | 2.87e-17 | 2.85e-15 | 88 |
| GO:00304331 | Liver | HCC | ubiquitin-dependent ERAD pathway | 72/7958 | 85/18723 | 9.78e-16 | 7.47e-14 | 72 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| JKAMP | SNV | Missense_Mutation | c.58C>G | p.Gln20Glu | p.Q20E | protein_coding | tolerated(0.33) | benign(0.017) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | ||
| JKAMP | SNV | Missense_Mutation | c.529T>C | p.Phe177Leu | p.F177L | protein_coding | tolerated(0.85) | benign(0.391) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| JKAMP | SNV | Missense_Mutation | c.898N>G | p.Thr300Ala | p.T300A | protein_coding | tolerated(0.34) | benign(0) | TCGA-AA-3854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| JKAMP | SNV | Missense_Mutation | c.393T>G | p.Ile131Met | p.I131M | protein_coding | deleterious(0) | benign(0.428) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
| JKAMP | SNV | Missense_Mutation | c.277N>C | p.Tyr93His | p.Y93H | protein_coding | tolerated(0.48) | benign(0.366) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| JKAMP | SNV | Missense_Mutation | c.772N>A | p.Leu258Ile | p.L258I | protein_coding | tolerated(0.06) | benign(0.319) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| JKAMP | SNV | Missense_Mutation | novel | c.833G>A | p.Gly278Glu | p.G278E | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| JKAMP | SNV | Missense_Mutation | novel | c.302C>A | p.Ala101Glu | p.A101E | protein_coding | tolerated(0.47) | possibly_damaging(0.698) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| JKAMP | SNV | Missense_Mutation | novel | c.444C>A | p.Asn148Lys | p.N148K | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| JKAMP | SNV | Missense_Mutation | c.812A>G | p.His271Arg | p.H271R | protein_coding | deleterious(0) | benign(0.343) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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