![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ITPRIPL2 |
Gene summary for ITPRIPL2 |
![]() |
Gene information | Species | Human | Gene symbol | ITPRIPL2 | Gene ID | 162073 |
Gene name | ITPRIP like 2 | |
Gene Alias | ITPRIPL2 | |
Cytomap | 16p12.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q3MIP1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
162073 | ITPRIPL2 | LZE20T | Human | Esophagus | ESCC | 2.01e-03 | 1.29e-01 | 0.0662 |
162073 | ITPRIPL2 | LZE24T | Human | Esophagus | ESCC | 3.22e-02 | 1.12e-01 | 0.0596 |
162073 | ITPRIPL2 | P1T-E | Human | Esophagus | ESCC | 5.36e-07 | 3.68e-01 | 0.0875 |
162073 | ITPRIPL2 | P2T-E | Human | Esophagus | ESCC | 1.75e-12 | 2.08e-01 | 0.1177 |
162073 | ITPRIPL2 | P4T-E | Human | Esophagus | ESCC | 9.35e-08 | 2.60e-01 | 0.1323 |
162073 | ITPRIPL2 | P5T-E | Human | Esophagus | ESCC | 1.88e-05 | 9.88e-02 | 0.1327 |
162073 | ITPRIPL2 | P8T-E | Human | Esophagus | ESCC | 3.05e-23 | 4.74e-01 | 0.0889 |
162073 | ITPRIPL2 | P9T-E | Human | Esophagus | ESCC | 4.36e-10 | 1.03e-01 | 0.1131 |
162073 | ITPRIPL2 | P10T-E | Human | Esophagus | ESCC | 3.76e-02 | 9.10e-02 | 0.116 |
162073 | ITPRIPL2 | P11T-E | Human | Esophagus | ESCC | 7.89e-10 | 3.48e-01 | 0.1426 |
162073 | ITPRIPL2 | P12T-E | Human | Esophagus | ESCC | 1.56e-12 | 3.21e-01 | 0.1122 |
162073 | ITPRIPL2 | P15T-E | Human | Esophagus | ESCC | 7.65e-11 | 2.05e-01 | 0.1149 |
162073 | ITPRIPL2 | P16T-E | Human | Esophagus | ESCC | 2.44e-05 | 7.42e-02 | 0.1153 |
162073 | ITPRIPL2 | P17T-E | Human | Esophagus | ESCC | 2.04e-05 | 1.90e-01 | 0.1278 |
162073 | ITPRIPL2 | P20T-E | Human | Esophagus | ESCC | 1.16e-19 | 4.82e-01 | 0.1124 |
162073 | ITPRIPL2 | P21T-E | Human | Esophagus | ESCC | 5.20e-10 | 1.06e-01 | 0.1617 |
162073 | ITPRIPL2 | P22T-E | Human | Esophagus | ESCC | 4.88e-08 | 1.22e-01 | 0.1236 |
162073 | ITPRIPL2 | P23T-E | Human | Esophagus | ESCC | 1.62e-12 | 5.14e-01 | 0.108 |
162073 | ITPRIPL2 | P24T-E | Human | Esophagus | ESCC | 3.16e-11 | 3.35e-01 | 0.1287 |
162073 | ITPRIPL2 | P26T-E | Human | Esophagus | ESCC | 4.17e-08 | 8.51e-02 | 0.1276 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITPRIPL2 | SNV | Missense_Mutation | novel | c.1279N>A | p.Glu427Lys | p.E427K | Q3MIP1 | protein_coding | tolerated(0.09) | benign(0.251) | TCGA-A7-A6VX-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
ITPRIPL2 | insertion | Frame_Shift_Ins | novel | c.1337_1338insCAGGAACGGGCAGCTCCAGGTGCCTGCTACCTCAA | p.Arg448AsnfsTer37 | p.R448Nfs*37 | Q3MIP1 | protein_coding | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ITPRIPL2 | insertion | In_Frame_Ins | novel | c.882_883insTCACTGCAGCCT | p.Cys294_Arg295insSerLeuGlnPro | p.C294_R295insSLQP | Q3MIP1 | protein_coding | TCGA-AO-A0JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophospamide | SD | ||
ITPRIPL2 | insertion | Frame_Shift_Ins | novel | c.941_942insACAACAAACAAACAAACAAACAAAAACAGGAAAGGCTCTCTTTTCT | p.His314GlnfsTer41 | p.H314Qfs*41 | Q3MIP1 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
ITPRIPL2 | deletion | Frame_Shift_Del | novel | c.1513delC | p.Gln505SerfsTer34 | p.Q505Sfs*34 | Q3MIP1 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ITPRIPL2 | SNV | Missense_Mutation | novel | c.782G>A | p.Arg261His | p.R261H | Q3MIP1 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ITPRIPL2 | SNV | Missense_Mutation | c.1586G>T | p.Gly529Val | p.G529V | Q3MIP1 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.881) | TCGA-A6-2681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ITPRIPL2 | SNV | Missense_Mutation | c.170N>A | p.Leu57His | p.L57H | Q3MIP1 | protein_coding | deleterious(0) | possibly_damaging(0.907) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ITPRIPL2 | SNV | Missense_Mutation | c.883C>T | p.Arg295Cys | p.R295C | Q3MIP1 | protein_coding | deleterious(0) | possibly_damaging(0.535) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ITPRIPL2 | SNV | Missense_Mutation | c.1370N>A | p.Gly457Asp | p.G457D | Q3MIP1 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |