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Gene: ITPA |
Gene summary for ITPA |
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Gene information | Species | Human | Gene symbol | ITPA | Gene ID | 3704 |
Gene name | inosine triphosphatase | |
Gene Alias | C20orf37 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0S2Z423 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3704 | ITPA | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.22e-03 | 3.14e-01 | -0.1808 |
3704 | ITPA | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.32e-06 | 4.73e-01 | -0.0811 |
3704 | ITPA | HTA11_347_2000001011 | Human | Colorectum | AD | 2.08e-05 | 2.60e-01 | -0.1954 |
3704 | ITPA | HTA11_696_2000001011 | Human | Colorectum | AD | 2.49e-05 | 3.34e-01 | -0.1464 |
3704 | ITPA | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.18e-07 | 5.57e-01 | -0.059 |
3704 | ITPA | HTA11_866_3004761011 | Human | Colorectum | AD | 3.45e-15 | 7.00e-01 | 0.096 |
3704 | ITPA | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.11e-04 | 7.55e-01 | 0.0171 |
3704 | ITPA | HTA11_10711_2000001011 | Human | Colorectum | AD | 8.31e-04 | 4.33e-01 | 0.0338 |
3704 | ITPA | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.00e-14 | 4.77e-01 | 0.0674 |
3704 | ITPA | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.11e-02 | 3.21e-01 | 0.294 |
3704 | ITPA | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.70e-08 | 6.33e-01 | 0.281 |
3704 | ITPA | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.41e-03 | 6.00e-01 | 0.2585 |
3704 | ITPA | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.30e-24 | 7.23e-01 | 0.3005 |
3704 | ITPA | A015-C-203 | Human | Colorectum | FAP | 2.26e-03 | -9.56e-02 | -0.1294 |
3704 | ITPA | A015-C-104 | Human | Colorectum | FAP | 1.48e-04 | 3.79e-03 | -0.1899 |
3704 | ITPA | A002-C-016 | Human | Colorectum | FAP | 5.75e-03 | -1.10e-01 | 0.0521 |
3704 | ITPA | A002-C-116 | Human | Colorectum | FAP | 5.13e-05 | -1.37e-01 | -0.0452 |
3704 | ITPA | LZE4T | Human | Esophagus | ESCC | 3.87e-18 | 3.53e-01 | 0.0811 |
3704 | ITPA | LZE7T | Human | Esophagus | ESCC | 6.73e-10 | 6.85e-01 | 0.0667 |
3704 | ITPA | LZE8T | Human | Esophagus | ESCC | 2.66e-10 | 2.49e-01 | 0.067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0009144 | Colorectum | AD | purine nucleoside triphosphate metabolic process | 43/3918 | 88/18723 | 5.05e-09 | 3.19e-07 | 43 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0009205 | Colorectum | AD | purine ribonucleoside triphosphate metabolic process | 39/3918 | 82/18723 | 6.58e-08 | 3.40e-06 | 39 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0009141 | Colorectum | AD | nucleoside triphosphate metabolic process | 48/3918 | 112/18723 | 1.27e-07 | 6.02e-06 | 48 |
GO:0009199 | Colorectum | AD | ribonucleoside triphosphate metabolic process | 40/3918 | 89/18723 | 3.04e-07 | 1.21e-05 | 40 |
GO:0006195 | Colorectum | AD | purine nucleotide catabolic process | 18/3918 | 46/18723 | 3.67e-03 | 2.60e-02 | 18 |
GO:0072523 | Colorectum | AD | purine-containing compound catabolic process | 19/3918 | 52/18723 | 6.92e-03 | 4.26e-02 | 19 |
GO:00061631 | Colorectum | SER | purine nucleotide metabolic process | 109/2897 | 396/18723 | 4.26e-10 | 5.44e-08 | 109 |
GO:00091501 | Colorectum | SER | purine ribonucleotide metabolic process | 103/2897 | 368/18723 | 4.69e-10 | 5.68e-08 | 103 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa00983 | Liver | Cirrhotic | Drug metabolism - other enzymes | 34/2530 | 80/8465 | 1.08e-02 | 3.57e-02 | 2.20e-02 | 34 |
hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa009831 | Liver | Cirrhotic | Drug metabolism - other enzymes | 34/2530 | 80/8465 | 1.08e-02 | 3.57e-02 | 2.20e-02 | 34 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa009832 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa009833 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0123221 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
hsa0123231 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITPA | SNV | Missense_Mutation | c.481N>A | p.Glu161Lys | p.E161K | Q9BY32 | protein_coding | tolerated(0.43) | benign(0.003) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ITPA | SNV | Missense_Mutation | rs142979373 | c.128N>T | p.Pro43Leu | p.P43L | Q9BY32 | protein_coding | tolerated(0.07) | benign(0.17) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
ITPA | SNV | Missense_Mutation | novel | c.562T>G | p.Tyr188Asp | p.Y188D | Q9BY32 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-AA-3678-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | CR |
ITPA | SNV | Missense_Mutation | rs777033296 | c.70N>A | p.Val24Ile | p.V24I | Q9BY32 | protein_coding | tolerated(0.32) | benign(0) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITPA | SNV | Missense_Mutation | rs776945646 | c.202N>A | p.Val68Met | p.V68M | Q9BY32 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ITPA | SNV | Missense_Mutation | rs538432614 | c.117N>C | p.Lys39Asn | p.K39N | Q9BY32 | protein_coding | tolerated(0.28) | benign(0.009) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
ITPA | SNV | Missense_Mutation | rs201119006 | c.184N>T | p.Arg62Cys | p.R62C | Q9BY32 | protein_coding | deleterious(0.01) | benign(0.018) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ITPA | SNV | Missense_Mutation | novel | c.457N>T | p.Pro153Ser | p.P153S | Q9BY32 | protein_coding | tolerated(0.13) | benign(0.21) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ITPA | SNV | Missense_Mutation | novel | c.19N>A | p.Gly7Arg | p.G7R | Q9BY32 | protein_coding | tolerated(0.14) | benign(0.005) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
ITPA | SNV | Missense_Mutation | novel | c.424G>A | p.Ala142Thr | p.A142T | Q9BY32 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3704 | ITPA | ENZYME | peginterferon alfa-2b | 26441325,23730840,21274861,26916827,26670100,20173735,26071337,23707372,26438033,21246582,27833958,20547162,21503919,20637204 | ||
3704 | ITPA | ENZYME | ribavirin | RIBAVIRIN | 26441325,25713999,23730840,21274861,26916827,26670100,20173735,26071337,23707372,26438033,21246582,27833958,20547162,21503919,20637204 | |
3704 | ITPA | ENZYME | peginterferon alfa-2a | 25713999 | ||
3704 | ITPA | ENZYME | mercaptopurine | MERCAPTOPURINE | 26237184,18685564,21395650 | |
3704 | ITPA | ENZYME | methotrexate | METHOTREXATE | 26237184,19858780,27217051,29520081,16947783 | |
3704 | ITPA | ENZYME | purine analogues | 19129747 | ||
3704 | ITPA | ENZYME | azathioprine | AZATHIOPRINE | 26674571,16431304,21961091,18616518,18662289,15973722,19129747 | |
3704 | ITPA | ENZYME | interferon alfa-2b, recombinant | 21503919 |
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