Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: ITGA3

Gene summary for ITGA3

Gene summary.

Gene information	Species	Human
	Gene symbol	ITGA3
	Gene ID	3675
	Gene name	integrin subunit alpha 3
	Gene Alias	CD49C
	Cytomap	17q21.33
	Gene Type	protein-coding
	GO ID	GO:0000003
	UniProtAcc	A0A140VJM0

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
3675	ITGA3	CA_HPV_1	Human	Cervix	CC	9.00e-07	-1.97e-01	0.0264
3675	ITGA3	CCI_2	Human	Cervix	CC	1.79e-13	1.19e+00	0.5249
3675	ITGA3	Tumor	Human	Cervix	CC	1.32e-05	2.88e-01	0.1241
3675	ITGA3	sample1	Human	Cervix	CC	1.87e-09	4.88e-01	0.0959
3675	ITGA3	sample3	Human	Cervix	CC	2.14e-10	4.40e-01	0.1387
3675	ITGA3	T1	Human	Cervix	CC	1.79e-17	5.22e-01	0.0918
3675	ITGA3	T3	Human	Cervix	CC	8.51e-14	4.04e-01	0.1389
3675	ITGA3	HTA11_2487_2000001011	Human	Colorectum	SER	2.40e-12	7.73e-01	-0.1808
3675	ITGA3	HTA11_1938_2000001011	Human	Colorectum	AD	1.45e-06	5.49e-01	-0.0811
3675	ITGA3	HTA11_347_2000001011	Human	Colorectum	AD	5.03e-25	8.07e-01	-0.1954
3675	ITGA3	HTA11_411_2000001011	Human	Colorectum	SER	7.91e-10	1.27e+00	-0.2602
3675	ITGA3	HTA11_83_2000001011	Human	Colorectum	SER	1.66e-02	4.94e-01	-0.1526
3675	ITGA3	HTA11_696_2000001011	Human	Colorectum	AD	7.50e-08	5.68e-01	-0.1464
3675	ITGA3	HTA11_866_2000001011	Human	Colorectum	AD	1.08e-03	3.55e-01	-0.1001
3675	ITGA3	HTA11_1391_2000001011	Human	Colorectum	AD	2.27e-06	5.55e-01	-0.059
3675	ITGA3	HTA11_546_2000001011	Human	Colorectum	AD	5.09e-03	5.41e-01	-0.0842
3675	ITGA3	A002-C-010	Human	Colorectum	FAP	3.40e-02	-1.82e-01	0.242
3675	ITGA3	A015-C-203	Human	Colorectum	FAP	1.56e-09	-1.89e-01	-0.1294
3675	ITGA3	A002-C-201	Human	Colorectum	FAP	8.70e-04	-1.99e-01	0.0324
3675	ITGA3	A001-C-108	Human	Colorectum	FAP	8.45e-06	-1.78e-01	-0.0272

Page: 1 2 3 4 5 6 7 8

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Cervix		CC: Cervix cancer
		HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
		N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)		FAP: Familial adenomatous polyposis
		CRC: Colorectal cancer
Colorectum (HTA11)		AD: Adenomas
		SER: Sessile serrated lesions
		MSI-H: Microsatellite-high colorectal cancer
		MSS: Microsatellite stable colorectal cancer
Esophagus		ESCC: Esophageal squamous cell carcinoma
		HGIN: High-grade intraepithelial neoplasias
		LGIN: Low-grade intraepithelial neoplasias
Liver		HCC: Hepatocellular carcinoma
		NAFLD: Non-alcoholic fatty liver disease
Lung		AAH: Atypical adenomatous hyperplasia
		AIS: Adenocarcinoma in situ
		IAC: Invasive lung adenocarcinoma
		MIA: Minimally invasive adenocarcinoma
Oral Cavity		EOLP: Erosive Oral lichen planus
		LP: leukoplakia
		NEOLP: Non-erosive oral lichen planus
		OSCC: Oral squamous cell carcinoma
Skin		AK: Actinic keratosis
		cSCC: Cutaneous squamous cell carcinoma
		SCCIS:squamous cell carcinoma in situ
Thyroid		ATC: Anaplastic thyroid cancer
		HT: Hashimoto's thyroiditis
		PTC: Papillary thyroid cancer

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:001081010	Cervix	CC	regulation of cell-substrate adhesion	69/2311	221/18723	8.57e-14	5.69e-11	69
GO:00315898	Cervix	CC	cell-substrate adhesion	96/2311	363/18723	1.48e-13	8.85e-11	96
GO:009013210	Cervix	CC	epithelium migration	90/2311	360/18723	2.45e-11	6.11e-09	90
GO:00016679	Cervix	CC	ameboidal-type cell migration	110/2311	475/18723	2.66e-11	6.36e-09	110
GO:001063110	Cervix	CC	epithelial cell migration	89/2311	357/18723	3.72e-11	8.54e-09	89
GO:009013010	Cervix	CC	tissue migration	90/2311	365/18723	5.42e-11	1.05e-08	90
GO:00435884	Cervix	CC	skin development	71/2311	263/18723	8.04e-11	1.46e-08	71
GO:004578510	Cervix	CC	positive regulation of cell adhesion	101/2311	437/18723	1.96e-10	3.08e-08	101
GO:190382910	Cervix	CC	positive regulation of cellular protein localization	72/2311	276/18723	3.20e-10	4.46e-08	72
GO:007265910	Cervix	CC	protein localization to plasma membrane	73/2311	284/18723	4.95e-10	6.73e-08	73
GO:00510566	Cervix	CC	regulation of small GTPase mediated signal transduction	75/2311	302/18723	1.54e-09	1.74e-07	75
GO:001063210	Cervix	CC	regulation of epithelial cell migration	72/2311	292/18723	4.52e-09	4.43e-07	72
GO:00160557	Cervix	CC	Wnt signaling pathway	98/2311	444/18723	4.82e-09	4.65e-07	98
GO:01987387	Cervix	CC	cell-cell signaling by wnt	98/2311	446/18723	6.16e-09	5.58e-07	98
GO:00072656	Cervix	CC	Ras protein signal transduction	79/2311	337/18723	9.49e-09	7.77e-07	79
GO:19907788	Cervix	CC	protein localization to cell periphery	78/2311	333/18723	1.22e-08	9.73e-07	78
GO:00071608	Cervix	CC	cell-matrix adhesion	60/2311	233/18723	1.58e-08	1.23e-06	60
GO:00301117	Cervix	CC	regulation of Wnt signaling pathway	76/2311	328/18723	3.05e-08	2.08e-06	76
GO:00072295	Cervix	CC	integrin-mediated signaling pathway	34/2311	107/18723	1.01e-07	5.25e-06	34
GO:00106349	Cervix	CC	positive regulation of epithelial cell migration	47/2311	176/18723	1.73e-07	8.01e-06	47

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41

Enriched KEGG pathways.

Pathway ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	qvalue	Count
hsa0451010	Cervix	CC	Focal adhesion	59/1267	203/8465	1.53e-07	1.84e-06	1.09e-06	59
hsa0481016	Cervix	CC	Regulation of actin cytoskeleton	64/1267	229/8465	2.24e-07	2.59e-06	1.53e-06	64
hsa052226	Cervix	CC	Small cell lung cancer	29/1267	92/8465	4.38e-05	3.09e-04	1.83e-04	29
hsa051657	Cervix	CC	Human papillomavirus infection	74/1267	331/8465	1.70e-04	1.02e-03	6.03e-04	74
hsa0451014	Cervix	CC	Focal adhesion	59/1267	203/8465	1.53e-07	1.84e-06	1.09e-06	59
hsa0481017	Cervix	CC	Regulation of actin cytoskeleton	64/1267	229/8465	2.24e-07	2.59e-06	1.53e-06	64
hsa0522213	Cervix	CC	Small cell lung cancer	29/1267	92/8465	4.38e-05	3.09e-04	1.83e-04	29
hsa0516512	Cervix	CC	Human papillomavirus infection	74/1267	331/8465	1.70e-04	1.02e-03	6.03e-04	74
hsa04810	Colorectum	AD	Regulation of actin cytoskeleton	75/2092	229/8465	3.36e-03	1.76e-02	1.12e-02	75
hsa04510	Colorectum	AD	Focal adhesion	67/2092	203/8465	4.40e-03	2.17e-02	1.38e-02	67
hsa048101	Colorectum	AD	Regulation of actin cytoskeleton	75/2092	229/8465	3.36e-03	1.76e-02	1.12e-02	75
hsa045101	Colorectum	AD	Focal adhesion	67/2092	203/8465	4.40e-03	2.17e-02	1.38e-02	67
hsa048102	Colorectum	SER	Regulation of actin cytoskeleton	60/1580	229/8465	2.74e-03	2.02e-02	1.47e-02	60
hsa048103	Colorectum	SER	Regulation of actin cytoskeleton	60/1580	229/8465	2.74e-03	2.02e-02	1.47e-02	60
hsa045102	Colorectum	FAP	Focal adhesion	61/1404	203/8465	1.03e-06	2.15e-05	1.31e-05	61
hsa048106	Colorectum	FAP	Regulation of actin cytoskeleton	65/1404	229/8465	4.07e-06	5.91e-05	3.59e-05	65
hsa05412	Colorectum	FAP	Arrhythmogenic right ventricular cardiomyopathy	23/1404	77/8465	2.58e-03	1.19e-02	7.23e-03	23
hsa04151	Colorectum	FAP	PI3K-Akt signaling pathway	75/1404	354/8465	1.23e-02	4.19e-02	2.55e-02	75
hsa052222	Colorectum	FAP	Small cell lung cancer	24/1404	92/8465	1.33e-02	4.46e-02	2.71e-02	24
hsa045103	Colorectum	FAP	Focal adhesion	61/1404	203/8465	1.03e-06	2.15e-05	1.31e-05	61

Page: 1 2 3 4 5 6

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand	Receptor	LRpair	Pathway	Tissue	Disease Stage
COL1A1	ITGA3_ITGB1	COL1A1_ITGA3_ITGB1	COLLAGEN	Cervix	ADJ
COL1A2	ITGA3_ITGB1	COL1A2_ITGA3_ITGB1	COLLAGEN	Cervix	ADJ
COL4A1	ITGA3_ITGB1	COL4A1_ITGA3_ITGB1	COLLAGEN	Cervix	ADJ
COL4A2	ITGA3_ITGB1	COL4A2_ITGA3_ITGB1	COLLAGEN	Cervix	ADJ
COL6A1	ITGA3_ITGB1	COL6A1_ITGA3_ITGB1	COLLAGEN	Cervix	ADJ
COL6A2	ITGA3_ITGB1	COL6A2_ITGA3_ITGB1	COLLAGEN	Cervix	ADJ
COL6A3	ITGA3_ITGB1	COL6A3_ITGA3_ITGB1	COLLAGEN	Cervix	ADJ
LAMA2	ITGA3_ITGB1	LAMA2_ITGA3_ITGB1	LAMININ	Cervix	ADJ
LAMA3	ITGA3_ITGB1	LAMA3_ITGA3_ITGB1	LAMININ	Cervix	ADJ
LAMA4	ITGA3_ITGB1	LAMA4_ITGA3_ITGB1	LAMININ	Cervix	ADJ
LAMA5	ITGA3_ITGB1	LAMA5_ITGA3_ITGB1	LAMININ	Cervix	ADJ
LAMB1	ITGA3_ITGB1	LAMB1_ITGA3_ITGB1	LAMININ	Cervix	ADJ
LAMB2	ITGA3_ITGB1	LAMB2_ITGA3_ITGB1	LAMININ	Cervix	ADJ
LAMB3	ITGA3_ITGB1	LAMB3_ITGA3_ITGB1	LAMININ	Cervix	ADJ
LAMC1	ITGA3_ITGB1	LAMC1_ITGA3_ITGB1	LAMININ	Cervix	ADJ
LAMC2	ITGA3_ITGB1	LAMC2_ITGA3_ITGB1	LAMININ	Cervix	ADJ
FN1	ITGA3_ITGB1	FN1_ITGA3_ITGB1	FN1	Cervix	ADJ
THBS1	ITGA3_ITGB1	THBS1_ITGA3_ITGB1	THBS	Cervix	ADJ
THBS2	ITGA3_ITGB1	THBS2_ITGA3_ITGB1	THBS	Cervix	ADJ
JAM2	ITGA3_ITGB1	JAM2_ITGA3_ITGB1	JAM	Cervix	ADJ

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

ITGA3

SNV

Missense_Mutation

novel

c.2758N>A

p.Asp920Asn

p.D920N

P26006

protein_coding

tolerated(1)

benign(0.007)

TCGA-BH-A2L8-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

cytoxan

ITGA3

SNV

Missense_Mutation

novel

c.1321N>T

p.Asp441Tyr

p.D441Y

P26006

protein_coding

deleterious(0)

probably_damaging(1)

TCGA-LL-A740-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

adriamycin

ITGA3

insertion

Frame_Shift_Ins

novel

c.1814_1815insG

p.Asn605LysfsTer4

p.N605Kfs*4

P26006

protein_coding

TCGA-A2-A0ER-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

cytoxan

ITGA3

insertion

Frame_Shift_Ins

novel

c.1815_1816insCCTGTCTCTCCTCTTGGAGGGT

p.His606ProfsTer10

p.H606Pfs*10

P26006

protein_coding

TCGA-A2-A0ER-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

cytoxan

ITGA3

insertion

Frame_Shift_Ins

novel

c.1760_1761insTATTA

p.Leu588IlefsTer54

p.L588Ifs*54

P26006

protein_coding

TCGA-C8-A12T-01

Breast

breast invasive carcinoma

Female

<65

I/II

Unknown

ITGA3

insertion

Nonsense_Mutation

novel

c.1761_1762insTCCACCTTTCCAAGTAGGATATAGTTAAGACA

p.Leu588SerfsTer8

p.L588Sfs*8

P26006

protein_coding

TCGA-C8-A12T-01

Breast

breast invasive carcinoma

Female

<65

I/II

Unknown

ITGA3

deletion

Frame_Shift_Del

novel

c.1335delN

p.Pro446GlnfsTer4

p.P446Qfs*4

P26006

protein_coding

TCGA-D8-A27V-01

Breast

breast invasive carcinoma

Female

<65

I/II

Hormone Therapy

tamoxiphen

ITGA3

SNV

Missense_Mutation

novel

c.3026N>G

p.Ile1009Ser

p.I1009S

P26006

protein_coding

deleterious(0)

probably_damaging(0.999)

TCGA-DS-A1OD-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

cisplatin

ITGA3

SNV

Missense_Mutation

rs140248487

c.2501N>T

p.Thr834Met

p.T834M

P26006

protein_coding

deleterious(0)

probably_damaging(0.989)

TCGA-EA-A410-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

ITGA3

SNV

Missense_Mutation

rs778130201

c.494G>A

p.Arg165Gln

p.R165Q

P26006

protein_coding

deleterious(0.01)

probably_damaging(0.988)

TCGA-FU-A3TX-01

Cervix

cervical & endocervical cancer

Female

>=65

I/II

Unknown

Page: 1 2 3 4 5 6 7 8 9

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID	Symbol	Category	Interaction Types	Drug Claim Name	Drug Name	PMIDs
3675	ITGA3	DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE		252827506

Page: 1