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Gene: ITFG1 |
Gene summary for ITFG1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ITFG1 | Gene ID | 81533 |
Gene name | integrin alpha FG-GAP repeat containing 1 | |
Gene Alias | 2310047C21Rik | |
Cytomap | 16q12.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B4DXC2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81533 | ITFG1 | CCI_1 | Human | Cervix | CC | 2.44e-08 | 1.10e+00 | 0.528 |
81533 | ITFG1 | CCI_2 | Human | Cervix | CC | 8.26e-05 | 8.57e-01 | 0.5249 |
81533 | ITFG1 | CCI_3 | Human | Cervix | CC | 1.28e-07 | 1.03e+00 | 0.516 |
81533 | ITFG1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.66e-26 | -7.28e-01 | 0.0155 |
81533 | ITFG1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.45e-04 | -4.29e-01 | -0.1808 |
81533 | ITFG1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.94e-02 | -6.25e-01 | 0.0216 |
81533 | ITFG1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.28e-13 | -6.11e-01 | -0.1207 |
81533 | ITFG1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.80e-07 | -2.83e-01 | -0.1464 |
81533 | ITFG1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.20e-02 | -4.71e-01 | -0.2061 |
81533 | ITFG1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.06e-04 | -8.08e-01 | -0.00410000000000005 |
81533 | ITFG1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.30e-05 | -4.19e-01 | -0.0179 |
81533 | ITFG1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.11e-21 | -6.12e-01 | 0.096 |
81533 | ITFG1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.57e-05 | -7.74e-01 | 0.0528 |
81533 | ITFG1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.07e-07 | -5.44e-01 | 0.0338 |
81533 | ITFG1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.13e-08 | -4.67e-01 | 0.0674 |
81533 | ITFG1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.33e-02 | -4.24e-01 | 0.0112 |
81533 | ITFG1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.18e-04 | -5.09e-01 | 0.0588 |
81533 | ITFG1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.62e-16 | -5.06e-01 | 0.294 |
81533 | ITFG1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.20e-03 | -3.39e-01 | 0.3859 |
81533 | ITFG1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 7.29e-06 | -5.33e-01 | 0.2585 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITFG1 | SNV | Missense_Mutation | c.853N>C | p.Cys285Arg | p.C285R | Q8TB96 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ITFG1 | SNV | Missense_Mutation | c.1433N>T | p.Gly478Val | p.G478V | Q8TB96 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A0XV-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ITFG1 | SNV | Missense_Mutation | novel | c.1306N>A | p.Asp436Asn | p.D436N | Q8TB96 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
ITFG1 | SNV | Missense_Mutation | novel | c.1207N>A | p.Asp403Asn | p.D403N | Q8TB96 | protein_coding | deleterious(0.01) | probably_damaging(0.909) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
ITFG1 | insertion | Frame_Shift_Ins | novel | c.848_849insCTGCTTAGTTGTTT | p.Lys283AsnfsTer6 | p.K283Nfs*6 | Q8TB96 | protein_coding | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
ITFG1 | SNV | Missense_Mutation | c.1594G>C | p.Glu532Gln | p.E532Q | Q8TB96 | protein_coding | deleterious(0.02) | possibly_damaging(0.899) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
ITFG1 | SNV | Missense_Mutation | c.1423N>A | p.Asp475Asn | p.D475N | Q8TB96 | protein_coding | tolerated(0.2) | probably_damaging(0.964) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ITFG1 | SNV | Missense_Mutation | novel | c.1435T>A | p.Tyr479Asn | p.Y479N | Q8TB96 | protein_coding | tolerated(0.33) | benign(0.012) | TCGA-VS-A8EC-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
ITFG1 | SNV | Missense_Mutation | c.487T>G | p.Phe163Val | p.F163V | Q8TB96 | protein_coding | tolerated(0.17) | benign(0.061) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ITFG1 | SNV | Missense_Mutation | c.1232N>G | p.Asp411Gly | p.D411G | Q8TB96 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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