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Gene: ISPD |
Gene summary for ISPD |
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Gene information | Species | Human | Gene symbol | ISPD | Gene ID | 729920 |
Gene name | CDP-L-ribitol pyrophosphorylase A | |
Gene Alias | ISPD | |
Cytomap | 7p21.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A140VJM1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
729920 | ISPD | NAFLD1 | Human | Liver | NAFLD | 1.84e-03 | 6.33e-01 | -0.04 |
729920 | ISPD | S43 | Human | Liver | Cirrhotic | 2.16e-04 | -1.44e-01 | -0.0187 |
729920 | ISPD | HCC1_Meng | Human | Liver | HCC | 7.23e-05 | -1.31e-01 | 0.0246 |
729920 | ISPD | HCC2_Meng | Human | Liver | HCC | 2.25e-02 | -1.06e-01 | 0.0107 |
729920 | ISPD | HCC2 | Human | Liver | HCC | 1.32e-03 | 1.55e+00 | 0.5341 |
729920 | ISPD | Pt13.a | Human | Liver | HCC | 2.16e-04 | -1.40e-01 | 0.021 |
729920 | ISPD | Pt14.d | Human | Liver | HCC | 2.16e-04 | -1.44e-01 | 0.0143 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ISPD | SNV | Missense_Mutation | novel | c.1300G>T | p.Ala434Ser | p.A434S | A4D126 | protein_coding | tolerated(0.42) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ISPD | insertion | Frame_Shift_Ins | novel | c.535-1_535insCTGGATCAGAAGAGAGAGAT | p.Ala179LeufsTer28 | p.A179Lfs*28 | A4D126 | protein_coding | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ISPD | deletion | Frame_Shift_Del | novel | c.730delN | p.Ala244ProfsTer2 | p.A244Pfs*2 | A4D126 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ISPD | SNV | Missense_Mutation | novel | c.539C>T | p.Ala180Val | p.A180V | A4D126 | protein_coding | deleterious(0) | possibly_damaging(0.744) | TCGA-A6-3807-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Ancillary | leucovorin | SD |
ISPD | SNV | Missense_Mutation | novel | c.1137T>G | p.Phe379Leu | p.F379L | A4D126 | protein_coding | tolerated(0.65) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ISPD | SNV | Missense_Mutation | c.1289N>A | p.Ala430Asp | p.A430D | A4D126 | protein_coding | deleterious(0) | benign(0.368) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ISPD | SNV | Missense_Mutation | c.1013N>G | p.Phe338Cys | p.F338C | A4D126 | protein_coding | deleterious(0) | possibly_damaging(0.87) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ISPD | SNV | Missense_Mutation | c.590G>A | p.Gly197Asp | p.G197D | A4D126 | protein_coding | deleterious(0.01) | possibly_damaging(0.688) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ISPD | SNV | Missense_Mutation | c.703G>A | p.Glu235Lys | p.E235K | A4D126 | protein_coding | deleterious(0.01) | probably_damaging(0.936) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ISPD | SNV | Missense_Mutation | rs868538735 | c.1314N>T | p.Lys438Asn | p.K438N | A4D126 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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