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Gene: ISOC2 |
Gene summary for ISOC2 |
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Gene information | Species | Human | Gene symbol | ISOC2 | Gene ID | 79763 |
Gene name | isochorismatase domain containing 2 | |
Gene Alias | ISOC2 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q96AB3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79763 | ISOC2 | GSM4909285 | Human | Breast | IDC | 3.86e-21 | 6.81e-01 | 0.21 |
79763 | ISOC2 | GSM4909291 | Human | Breast | IDC | 3.54e-05 | 3.95e-01 | 0.1753 |
79763 | ISOC2 | GSM4909294 | Human | Breast | IDC | 3.17e-10 | 5.61e-01 | 0.2022 |
79763 | ISOC2 | GSM4909297 | Human | Breast | IDC | 5.74e-04 | -5.68e-02 | 0.1517 |
79763 | ISOC2 | GSM4909308 | Human | Breast | IDC | 6.06e-04 | 2.72e-01 | 0.158 |
79763 | ISOC2 | GSM4909311 | Human | Breast | IDC | 2.93e-19 | -7.35e-02 | 0.1534 |
79763 | ISOC2 | GSM4909312 | Human | Breast | IDC | 3.40e-06 | 5.84e-02 | 0.1552 |
79763 | ISOC2 | GSM4909319 | Human | Breast | IDC | 1.43e-23 | 4.05e-04 | 0.1563 |
79763 | ISOC2 | GSM4909320 | Human | Breast | IDC | 2.80e-02 | 3.09e-01 | 0.1575 |
79763 | ISOC2 | GSM4909321 | Human | Breast | IDC | 1.06e-10 | 2.27e-01 | 0.1559 |
79763 | ISOC2 | DCIS2 | Human | Breast | DCIS | 1.28e-27 | 1.47e-02 | 0.0085 |
79763 | ISOC2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.63e-04 | 2.63e-01 | -0.1808 |
79763 | ISOC2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.57e-02 | 2.16e-01 | -0.0811 |
79763 | ISOC2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.90e-15 | 4.29e-01 | -0.1954 |
79763 | ISOC2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 9.76e-03 | 4.73e-01 | -0.2196 |
79763 | ISOC2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.24e-03 | 3.77e-01 | -0.1207 |
79763 | ISOC2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.94e-02 | 3.47e-01 | -0.1526 |
79763 | ISOC2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.17e-07 | 3.31e-01 | -0.1464 |
79763 | ISOC2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.05e-14 | 4.63e-01 | -0.059 |
79763 | ISOC2 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.79e-02 | 3.28e-01 | -0.0842 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003164714 | Breast | IDC | regulation of protein stability | 50/1434 | 298/18723 | 1.14e-07 | 6.57e-06 | 50 |
GO:003164724 | Breast | DCIS | regulation of protein stability | 51/1390 | 298/18723 | 1.63e-08 | 1.15e-06 | 51 |
GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
GO:00316471 | Colorectum | SER | regulation of protein stability | 86/2897 | 298/18723 | 2.56e-09 | 2.42e-07 | 86 |
GO:00316472 | Colorectum | MSS | regulation of protein stability | 103/3467 | 298/18723 | 2.52e-11 | 3.49e-09 | 103 |
GO:003164727 | Esophagus | HGIN | regulation of protein stability | 96/2587 | 298/18723 | 2.21e-16 | 5.76e-14 | 96 |
GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
GO:00316486 | Esophagus | ESCC | protein destabilization | 33/8552 | 46/18723 | 3.06e-04 | 1.83e-03 | 33 |
GO:003164712 | Liver | Cirrhotic | regulation of protein stability | 144/4634 | 298/18723 | 6.74e-19 | 1.28e-16 | 144 |
GO:00316481 | Liver | Cirrhotic | protein destabilization | 20/4634 | 46/18723 | 4.15e-03 | 2.22e-02 | 20 |
GO:003164722 | Liver | HCC | regulation of protein stability | 211/7958 | 298/18723 | 2.29e-23 | 5.01e-21 | 211 |
GO:00316482 | Liver | HCC | protein destabilization | 29/7958 | 46/18723 | 3.95e-03 | 1.74e-02 | 29 |
GO:003164720 | Oral cavity | OSCC | regulation of protein stability | 193/7305 | 298/18723 | 1.30e-19 | 1.95e-17 | 193 |
GO:00316485 | Oral cavity | OSCC | protein destabilization | 29/7305 | 46/18723 | 8.26e-04 | 4.38e-03 | 29 |
GO:0031647110 | Oral cavity | LP | regulation of protein stability | 132/4623 | 298/18723 | 8.16e-14 | 7.99e-12 | 132 |
GO:003164729 | Skin | cSCC | regulation of protein stability | 144/4864 | 298/18723 | 6.51e-17 | 6.80e-15 | 144 |
GO:0031647113 | Thyroid | PTC | regulation of protein stability | 174/5968 | 298/18723 | 2.05e-21 | 4.05e-19 | 174 |
GO:003164734 | Thyroid | ATC | regulation of protein stability | 177/6293 | 298/18723 | 4.08e-20 | 6.46e-18 | 177 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ISOC2 | SNV | Missense_Mutation | c.293N>T | p.Arg98Leu | p.R98L | Q96AB3 | protein_coding | tolerated(0.71) | benign(0.006) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ISOC2 | SNV | Missense_Mutation | rs561051209 | c.83G>A | p.Arg28His | p.R28H | Q96AB3 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AA-A024-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ISOC2 | SNV | Missense_Mutation | novel | c.622N>A | p.Gly208Arg | p.G208R | Q96AB3 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ISOC2 | SNV | Missense_Mutation | rs537689871 | c.464N>A | p.Arg155His | p.R155H | Q96AB3 | protein_coding | deleterious(0.02) | benign(0.16) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ISOC2 | SNV | Missense_Mutation | rs561051209 | c.83G>A | p.Arg28His | p.R28H | Q96AB3 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ISOC2 | SNV | Missense_Mutation | novel | c.138N>T | p.Lys46Asn | p.K46N | Q96AB3 | protein_coding | deleterious(0.04) | benign(0.161) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ISOC2 | SNV | Missense_Mutation | novel | c.190N>T | p.Gly64Cys | p.G64C | Q96AB3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A3FS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ISOC2 | SNV | Missense_Mutation | novel | c.398N>G | p.Asn133Ser | p.N133S | Q96AB3 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ISOC2 | SNV | Missense_Mutation | c.535N>T | p.Gly179Trp | p.G179W | Q96AB3 | protein_coding | deleterious(0.01) | probably_damaging(0.915) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
ISOC2 | SNV | Missense_Mutation | novel | c.646N>A | p.Gln216Lys | p.Q216K | Q96AB3 | protein_coding | tolerated_low_confidence(0.16) | benign(0.007) | TCGA-FI-A2D6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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