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Gene: IQSEC2 |
Gene summary for IQSEC2 |
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Gene information | Species | Human | Gene symbol | IQSEC2 | Gene ID | 23096 |
Gene name | IQ motif and Sec7 domain ArfGEF 2 | |
Gene Alias | BRAG1 | |
Cytomap | Xp11.22 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q5JU85 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23096 | IQSEC2 | HCC2_Meng | Human | Liver | HCC | 2.75e-06 | 5.90e-02 | 0.0107 |
23096 | IQSEC2 | HCC2 | Human | Liver | HCC | 1.32e-03 | 8.90e-01 | 0.5341 |
23096 | IQSEC2 | S027 | Human | Liver | HCC | 5.76e-05 | 2.13e-01 | 0.2446 |
23096 | IQSEC2 | S028 | Human | Liver | HCC | 8.36e-16 | 4.52e-01 | 0.2503 |
23096 | IQSEC2 | S029 | Human | Liver | HCC | 3.57e-22 | 6.84e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:199077821 | Liver | HCC | protein localization to cell periphery | 200/7958 | 333/18723 | 6.07e-11 | 2.23e-09 | 200 |
GO:190547511 | Liver | HCC | regulation of protein localization to membrane | 113/7958 | 175/18723 | 2.90e-09 | 7.78e-08 | 113 |
GO:190437521 | Liver | HCC | regulation of protein localization to cell periphery | 83/7958 | 125/18723 | 5.60e-08 | 1.19e-06 | 83 |
GO:000726521 | Liver | HCC | Ras protein signal transduction | 187/7958 | 337/18723 | 8.89e-07 | 1.35e-05 | 187 |
GO:00315031 | Liver | HCC | protein-containing complex localization | 129/7958 | 220/18723 | 9.38e-07 | 1.42e-05 | 129 |
GO:004657811 | Liver | HCC | regulation of Ras protein signal transduction | 100/7958 | 189/18723 | 2.42e-03 | 1.18e-02 | 100 |
GO:1902683 | Liver | HCC | regulation of receptor localization to synapse | 13/7958 | 18/18723 | 1.05e-02 | 3.89e-02 | 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IQSEC2 | SNV | Missense_Mutation | c.3438N>G | p.Asp1146Glu | p.D1146E | Q5JU85 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-A1-A0SN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD | |
IQSEC2 | SNV | Missense_Mutation | novel | c.3871N>T | p.Pro1291Ser | p.P1291S | Q5JU85 | protein_coding | deleterious_low_confidence(0.02) | benign(0.028) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
IQSEC2 | SNV | Missense_Mutation | c.3775N>C | p.Asp1259His | p.D1259H | Q5JU85 | protein_coding | deleterious_low_confidence(0.04) | benign(0.265) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IQSEC2 | SNV | Missense_Mutation | c.1354N>C | p.Glu452Gln | p.E452Q | Q5JU85 | protein_coding | deleterious(0.04) | benign(0.399) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IQSEC2 | SNV | Missense_Mutation | novel | c.3143N>G | p.Ser1048Cys | p.S1048C | Q5JU85 | protein_coding | deleterious(0.02) | probably_damaging(0.973) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
IQSEC2 | SNV | Missense_Mutation | c.3082N>C | p.Val1028Leu | p.V1028L | Q5JU85 | protein_coding | tolerated(0.55) | benign(0.102) | TCGA-AN-A0AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IQSEC2 | SNV | Missense_Mutation | c.1001N>A | p.Val334Glu | p.V334E | Q5JU85 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AR-A251-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
IQSEC2 | SNV | Missense_Mutation | rs782769582 | c.1111C>A | p.Arg371Ser | p.R371S | Q5JU85 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BH-A0DD-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | CR |
IQSEC2 | SNV | Missense_Mutation | c.1235N>T | p.Ser412Leu | p.S412L | Q5JU85 | protein_coding | tolerated_low_confidence(0.11) | possibly_damaging(0.838) | TCGA-BH-A0H7-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
IQSEC2 | SNV | Missense_Mutation | rs782769582 | c.1111N>A | p.Arg371Ser | p.R371S | Q5JU85 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BH-A1EV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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