Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: IQCE

Gene summary for IQCE

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

IQCE

Gene ID

23288

Gene nameIQ motif containing E
Gene Alias1700028P05Rik
Cytomap7p22.3
Gene Typeprotein-coding
GO ID

GO:0007275

UniProtAcc

A0A087WX45


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
23288IQCELZE22THumanEsophagusESCC4.30e-022.30e-010.068
23288IQCELZE24THumanEsophagusESCC4.01e-021.13e-010.0596
23288IQCEP1T-EHumanEsophagusESCC3.67e-042.37e-010.0875
23288IQCEP2T-EHumanEsophagusESCC1.57e-173.72e-010.1177
23288IQCEP4T-EHumanEsophagusESCC2.27e-061.00e-010.1323
23288IQCEP8T-EHumanEsophagusESCC5.85e-071.27e-010.0889
23288IQCEP10T-EHumanEsophagusESCC6.41e-041.20e-010.116
23288IQCEP11T-EHumanEsophagusESCC2.20e-042.72e-010.1426
23288IQCEP12T-EHumanEsophagusESCC1.46e-099.28e-020.1122
23288IQCEP15T-EHumanEsophagusESCC1.83e-101.64e-010.1149
23288IQCEP16T-EHumanEsophagusESCC4.60e-112.15e-010.1153
23288IQCEP19T-EHumanEsophagusESCC1.10e-032.92e-010.1662
23288IQCEP20T-EHumanEsophagusESCC1.28e-081.18e-010.1124
23288IQCEP21T-EHumanEsophagusESCC9.56e-081.46e-010.1617
23288IQCEP22T-EHumanEsophagusESCC1.22e-091.84e-010.1236
23288IQCEP23T-EHumanEsophagusESCC5.87e-061.42e-010.108
23288IQCEP26T-EHumanEsophagusESCC7.58e-071.48e-010.1276
23288IQCEP27T-EHumanEsophagusESCC5.14e-092.27e-010.1055
23288IQCEP28T-EHumanEsophagusESCC7.28e-091.49e-010.1149
23288IQCEP30T-EHumanEsophagusESCC1.37e-041.94e-010.137
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00487367EsophagusESCCappendage development98/8552172/187231.83e-038.37e-0398
GO:00601737EsophagusESCClimb development98/8552172/187231.83e-038.37e-0398
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
IQCESNVMissense_Mutationrs555990190c.506N>Tp.Thr169Metp.T169Mprotein_codingdeleterious(0)probably_damaging(0.981)TCGA-AR-A5QQ-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapycarboplatinPD
IQCEinsertionFrame_Shift_Insnovelc.1906_1907insAAATTACTp.Arg636LysfsTer40p.R636Kfs*40protein_codingTCGA-A7-A0CG-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
IQCEinsertionFrame_Shift_Insnovelc.1907_1908insAGGCTGCTGTAAACCTCAGAp.Arg637GlyfsTer43p.R637Gfs*43protein_codingTCGA-A7-A0CG-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
IQCEinsertionFrame_Shift_Insnovelc.283_284insGp.Ser95CysfsTer18p.S95Cfs*18protein_codingTCGA-A8-A079-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapy5-fluorouracilSD
IQCEinsertionNonsense_Mutationnovelc.284_285insAGTGGAACCAGATCTGGACCCCGTTCTGTGAGATCTGGp.Pro96ValfsTer10p.P96Vfs*10protein_codingTCGA-A8-A079-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapy5-fluorouracilSD
IQCEinsertionFrame_Shift_Insnovelc.1108_1109insACAGGAGGGAAGATGTGCAGAGTCGTTTGAGTCCp.Ala370AspfsTer122p.A370Dfs*122protein_codingTCGA-BH-A0BM-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
IQCESNVMissense_Mutationnovelc.501N>Ap.Met167Ilep.M167Iprotein_codingdeleterious(0)possibly_damaging(0.611)TCGA-C5-A8XJ-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinSD
IQCESNVMissense_Mutationrs775017409c.363N>Cp.Lys121Asnp.K121Nprotein_codingdeleterious(0)possibly_damaging(0.802)TCGA-IR-A3LK-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinPD
IQCESNVMissense_Mutationrs779690833c.1217C>Tp.Ala406Valp.A406Vprotein_codingdeleterious(0.05)benign(0.03)TCGA-AA-3492-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
IQCESNVMissense_Mutationnovelc.1621N>Ap.Val541Ilep.V541Iprotein_codingtolerated(0.16)benign(0.071)TCGA-AA-3860-01Colorectumcolon adenocarcinomaFemale<65III/IVChemotherapyfolinicCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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