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Gene: INTU |
Gene summary for INTU |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | INTU | Gene ID | 27152 |
| Gene name | inturned planar cell polarity protein | |
| Gene Alias | CPLANE4 | |
| Cytomap | 4q28.1 | |
| Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | Q9ULD6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 27152 | INTU | HTA12-23-1 | Human | Pancreas | PDAC | 5.20e-08 | 6.61e-01 | 0.3405 |
| 27152 | INTU | HTA12-25-1 | Human | Pancreas | PDAC | 3.33e-07 | 4.94e-01 | 0.313 |
| 27152 | INTU | HTA12-26-1 | Human | Pancreas | PDAC | 1.03e-14 | 6.60e-01 | 0.3728 |
| 27152 | INTU | HTA12-29-1 | Human | Pancreas | PDAC | 6.38e-18 | 4.06e-01 | 0.3722 |
| 27152 | INTU | male-WTA | Human | Thyroid | PTC | 6.57e-12 | 9.87e-02 | 0.1037 |
| 27152 | INTU | PTC01 | Human | Thyroid | PTC | 2.37e-19 | 2.43e-01 | 0.1899 |
| 27152 | INTU | PTC03 | Human | Thyroid | PTC | 2.47e-09 | 2.81e-01 | 0.1784 |
| 27152 | INTU | PTC04 | Human | Thyroid | PTC | 1.81e-12 | 2.09e-01 | 0.1927 |
| 27152 | INTU | PTC05 | Human | Thyroid | PTC | 1.87e-13 | 5.48e-01 | 0.2065 |
| 27152 | INTU | PTC06 | Human | Thyroid | PTC | 1.08e-22 | 5.14e-01 | 0.2057 |
| 27152 | INTU | PTC07 | Human | Thyroid | PTC | 1.72e-35 | 5.86e-01 | 0.2044 |
| 27152 | INTU | ATC09 | Human | Thyroid | ATC | 4.71e-02 | 1.17e-01 | 0.2871 |
| 27152 | INTU | ATC12 | Human | Thyroid | ATC | 5.38e-13 | 1.52e-01 | 0.34 |
| 27152 | INTU | ATC13 | Human | Thyroid | ATC | 9.79e-26 | 4.11e-01 | 0.34 |
| 27152 | INTU | ATC2 | Human | Thyroid | ATC | 9.60e-13 | 7.16e-01 | 0.34 |
| 27152 | INTU | ATC3 | Human | Thyroid | ATC | 1.74e-03 | 1.83e-01 | 0.338 |
| 27152 | INTU | ATC4 | Human | Thyroid | ATC | 2.26e-15 | 1.73e-01 | 0.34 |
| 27152 | INTU | ATC5 | Human | Thyroid | ATC | 7.61e-28 | 4.45e-01 | 0.34 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0001503110 | Thyroid | PTC | ossification | 176/5968 | 408/18723 | 9.26e-07 | 1.40e-05 | 176 |
| GO:002191514 | Thyroid | PTC | neural tube development | 76/5968 | 152/18723 | 2.40e-06 | 3.17e-05 | 76 |
| GO:00302785 | Thyroid | PTC | regulation of ossification | 51/5968 | 115/18723 | 3.30e-03 | 1.61e-02 | 51 |
| GO:00017389 | Thyroid | PTC | morphogenesis of a polarized epithelium | 41/5968 | 94/18723 | 1.10e-02 | 4.38e-02 | 41 |
| GO:000150332 | Thyroid | ATC | ossification | 206/6293 | 408/18723 | 9.23e-13 | 3.95e-11 | 206 |
| GO:002191515 | Thyroid | ATC | neural tube development | 80/6293 | 152/18723 | 9.87e-07 | 1.29e-05 | 80 |
| GO:003027813 | Thyroid | ATC | regulation of ossification | 60/6293 | 115/18723 | 3.01e-05 | 2.51e-04 | 60 |
| GO:00513027 | Thyroid | ATC | regulation of cell division | 80/6293 | 177/18723 | 8.54e-04 | 4.68e-03 | 80 |
| GO:00600211 | Thyroid | ATC | roof of mouth development | 42/6293 | 85/18723 | 1.83e-03 | 9.02e-03 | 42 |
| GO:00351074 | Thyroid | ATC | appendage morphogenesis | 63/6293 | 138/18723 | 2.13e-03 | 1.00e-02 | 63 |
| GO:00351084 | Thyroid | ATC | limb morphogenesis | 63/6293 | 138/18723 | 2.13e-03 | 1.00e-02 | 63 |
| GO:0008589 | Thyroid | ATC | regulation of smoothened signaling pathway | 40/6293 | 81/18723 | 2.36e-03 | 1.10e-02 | 40 |
| GO:00487368 | Thyroid | ATC | appendage development | 76/6293 | 172/18723 | 2.41e-03 | 1.12e-02 | 76 |
| GO:00601738 | Thyroid | ATC | limb development | 76/6293 | 172/18723 | 2.41e-03 | 1.12e-02 | 76 |
| GO:000173814 | Thyroid | ATC | morphogenesis of a polarized epithelium | 45/6293 | 94/18723 | 2.86e-03 | 1.30e-02 | 45 |
| GO:0050673111 | Thyroid | ATC | epithelial cell proliferation | 174/6293 | 437/18723 | 3.49e-03 | 1.55e-02 | 174 |
| GO:0050678110 | Thyroid | ATC | regulation of epithelial cell proliferation | 151/6293 | 381/18723 | 7.47e-03 | 2.92e-02 | 151 |
| GO:00303262 | Thyroid | ATC | embryonic limb morphogenesis | 52/6293 | 116/18723 | 7.67e-03 | 3.00e-02 | 52 |
| GO:00351132 | Thyroid | ATC | embryonic appendage morphogenesis | 52/6293 | 116/18723 | 7.67e-03 | 3.00e-02 | 52 |
| GO:0007224 | Thyroid | ATC | smoothened signaling pathway | 60/6293 | 138/18723 | 9.75e-03 | 3.57e-02 | 60 |
| Page: 1 2 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| INTU | SNV | Missense_Mutation | c.824N>A | p.Arg275Lys | p.R275K | Q9ULD6 | protein_coding | tolerated(0.71) | benign(0) | TCGA-A2-A0CM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD | |
| INTU | SNV | Missense_Mutation | novel | c.1575N>C | p.Leu525Phe | p.L525F | Q9ULD6 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
| INTU | SNV | Missense_Mutation | c.55N>A | p.Asp19Asn | p.D19N | Q9ULD6 | protein_coding | tolerated_low_confidence(0.06) | benign(0.196) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| INTU | SNV | Missense_Mutation | c.593N>A | p.Arg198Lys | p.R198K | Q9ULD6 | protein_coding | tolerated(0.15) | benign(0) | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
| INTU | SNV | Missense_Mutation | c.97N>C | p.Asp33His | p.D33H | Q9ULD6 | protein_coding | deleterious(0.01) | benign(0.443) | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| INTU | SNV | Missense_Mutation | c.2557N>A | p.Glu853Lys | p.E853K | Q9ULD6 | protein_coding | tolerated(0.5) | benign(0.003) | TCGA-AO-A0JC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
| INTU | SNV | Missense_Mutation | c.2804A>C | p.Lys935Thr | p.K935T | Q9ULD6 | protein_coding | deleterious(0) | possibly_damaging(0.714) | TCGA-BH-A1F6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| INTU | SNV | Missense_Mutation | rs376167283 | c.1337C>T | p.Ala446Val | p.A446V | Q9ULD6 | protein_coding | tolerated(0.25) | benign(0.052) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| INTU | SNV | Missense_Mutation | rs755278340 | c.1735A>G | p.Thr579Ala | p.T579A | Q9ULD6 | protein_coding | tolerated(0.75) | benign(0) | TCGA-BI-A0VS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| INTU | SNV | Missense_Mutation | c.2144N>A | p.Gly715Glu | p.G715E | Q9ULD6 | protein_coding | tolerated(0.21) | benign(0.127) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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