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Gene: INPP5J |
Gene summary for INPP5J |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | INPP5J | Gene ID | 27124 |
| Gene name | inositol polyphosphate-5-phosphatase J | |
| Gene Alias | INPP5 | |
| Cytomap | 22q12.2 | |
| Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q15735 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 27124 | INPP5J | Adj_PTCwithHT_6 | Human | Thyroid | HT | 5.67e-05 | -2.47e-01 | 0.02 |
| 27124 | INPP5J | male-WTA | Human | Thyroid | PTC | 2.10e-29 | 3.12e-01 | 0.1037 |
| 27124 | INPP5J | PTC01 | Human | Thyroid | PTC | 5.03e-10 | 3.58e-01 | 0.1899 |
| 27124 | INPP5J | PTC04 | Human | Thyroid | PTC | 4.78e-12 | 3.87e-01 | 0.1927 |
| 27124 | INPP5J | PTC05 | Human | Thyroid | PTC | 4.01e-11 | 4.94e-01 | 0.2065 |
| 27124 | INPP5J | PTC06 | Human | Thyroid | PTC | 3.38e-17 | 5.44e-01 | 0.2057 |
| 27124 | INPP5J | PTC07 | Human | Thyroid | PTC | 4.20e-19 | 4.65e-01 | 0.2044 |
| 27124 | INPP5J | ATC12 | Human | Thyroid | ATC | 1.21e-04 | -2.53e-01 | 0.34 |
| 27124 | INPP5J | ATC13 | Human | Thyroid | ATC | 3.13e-03 | -2.33e-01 | 0.34 |
| 27124 | INPP5J | ATC4 | Human | Thyroid | ATC | 9.61e-03 | -2.53e-01 | 0.34 |
| 27124 | INPP5J | ATC5 | Human | Thyroid | ATC | 1.08e-02 | -2.34e-01 | 0.34 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000193327 | Thyroid | HT | negative regulation of protein phosphorylation | 45/1272 | 342/18723 | 1.54e-05 | 3.80e-04 | 45 |
| GO:004232627 | Thyroid | HT | negative regulation of phosphorylation | 49/1272 | 385/18723 | 1.62e-05 | 3.95e-04 | 49 |
| GO:004593629 | Thyroid | HT | negative regulation of phosphate metabolic process | 54/1272 | 441/18723 | 1.86e-05 | 4.39e-04 | 54 |
| GO:001056329 | Thyroid | HT | negative regulation of phosphorus metabolic process | 54/1272 | 442/18723 | 1.99e-05 | 4.60e-04 | 54 |
| GO:190290330 | Thyroid | HT | regulation of supramolecular fiber organization | 47/1272 | 383/18723 | 6.02e-05 | 1.13e-03 | 47 |
| GO:003133327 | Thyroid | HT | negative regulation of protein-containing complex assembly | 23/1272 | 141/18723 | 7.64e-05 | 1.37e-03 | 23 |
| GO:004325430 | Thyroid | HT | regulation of protein-containing complex assembly | 50/1272 | 428/18723 | 1.24e-04 | 2.00e-03 | 50 |
| GO:001097519 | Thyroid | HT | regulation of neuron projection development | 50/1272 | 445/18723 | 3.18e-04 | 4.18e-03 | 50 |
| GO:001063925 | Thyroid | HT | negative regulation of organelle organization | 39/1272 | 348/18723 | 1.45e-03 | 1.36e-02 | 39 |
| GO:005125828 | Thyroid | HT | protein polymerization | 34/1272 | 297/18723 | 1.99e-03 | 1.77e-02 | 34 |
| GO:190290420 | Thyroid | HT | negative regulation of supramolecular fiber organization | 22/1272 | 167/18723 | 2.14e-03 | 1.87e-02 | 22 |
| GO:003111310 | Thyroid | HT | regulation of microtubule polymerization | 10/1272 | 55/18723 | 3.57e-03 | 2.73e-02 | 10 |
| GO:003227128 | Thyroid | HT | regulation of protein polymerization | 27/1272 | 233/18723 | 4.64e-03 | 3.28e-02 | 27 |
| GO:007050710 | Thyroid | HT | regulation of microtubule cytoskeleton organization | 19/1272 | 148/18723 | 5.50e-03 | 3.62e-02 | 19 |
| GO:1902903113 | Thyroid | PTC | regulation of supramolecular fiber organization | 202/5968 | 383/18723 | 1.16e-17 | 1.15e-15 | 202 |
| GO:0043254113 | Thyroid | PTC | regulation of protein-containing complex assembly | 215/5968 | 428/18723 | 1.23e-15 | 9.09e-14 | 215 |
| GO:0010563113 | Thyroid | PTC | negative regulation of phosphorus metabolic process | 219/5968 | 442/18723 | 4.47e-15 | 3.07e-13 | 219 |
| GO:0045936113 | Thyroid | PTC | negative regulation of phosphate metabolic process | 218/5968 | 441/18723 | 7.08e-15 | 4.75e-13 | 218 |
| GO:0001933113 | Thyroid | PTC | negative regulation of protein phosphorylation | 173/5968 | 342/18723 | 3.46e-13 | 1.75e-11 | 173 |
| GO:0051258113 | Thyroid | PTC | protein polymerization | 154/5968 | 297/18723 | 5.35e-13 | 2.66e-11 | 154 |
| Page: 1 2 3 4 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| INPP5J | SNV | Missense_Mutation | rs368017167 | c.2234N>G | p.Val745Gly | p.V745G | Q15735 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-A2-A1G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
| INPP5J | SNV | Missense_Mutation | c.1301N>A | p.Thr434Asn | p.T434N | Q15735 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
| INPP5J | SNV | Missense_Mutation | rs767028605 | c.1378G>A | p.Ala460Thr | p.A460T | Q15735 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| INPP5J | SNV | Missense_Mutation | rs760040491 | c.2231N>G | p.Glu744Gly | p.E744G | Q15735 | protein_coding | deleterious(0.05) | possibly_damaging(0.532) | TCGA-E9-A1RE-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
| INPP5J | SNV | Missense_Mutation | rs529365616 | c.1627N>A | p.Val543Met | p.V543M | Q15735 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A7CJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
| INPP5J | SNV | Missense_Mutation | c.2368N>A | p.Val790Ile | p.V790I | Q15735 | protein_coding | deleterious(0.04) | benign(0.325) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
| INPP5J | SNV | Missense_Mutation | rs760092310 | c.1589N>A | p.Arg530His | p.R530H | Q15735 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| INPP5J | SNV | Missense_Mutation | c.1547A>G | p.Tyr516Cys | p.Y516C | Q15735 | protein_coding | tolerated(0.1) | benign(0.187) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| INPP5J | SNV | Missense_Mutation | rs760092310 | c.1589N>A | p.Arg530His | p.R530H | Q15735 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| INPP5J | SNV | Missense_Mutation | rs759418802 | c.2342N>A | p.Arg781His | p.R781H | Q15735 | protein_coding | deleterious(0.03) | probably_damaging(0.972) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
| Page: 1 2 3 4 5 6 7 8 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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