![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: IMPAD1 |
Gene summary for IMPAD1 |
![]() |
Gene information | Species | Human | Gene symbol | IMPAD1 | Gene ID | 54928 |
Gene name | 3'(2'), 5'-bisphosphate nucleotidase 2 | |
Gene Alias | GPAPP | |
Cytomap | 8q12.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | A0A024R7W0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54928 | IMPAD1 | LZE20T | Human | Esophagus | ESCC | 8.93e-03 | 5.48e-03 | 0.0662 |
54928 | IMPAD1 | LZE24T | Human | Esophagus | ESCC | 8.72e-09 | 9.10e-02 | 0.0596 |
54928 | IMPAD1 | P2T-E | Human | Esophagus | ESCC | 7.27e-09 | 1.50e-01 | 0.1177 |
54928 | IMPAD1 | P4T-E | Human | Esophagus | ESCC | 1.55e-22 | 6.50e-01 | 0.1323 |
54928 | IMPAD1 | P5T-E | Human | Esophagus | ESCC | 2.57e-12 | 2.70e-01 | 0.1327 |
54928 | IMPAD1 | P8T-E | Human | Esophagus | ESCC | 3.28e-09 | 1.47e-01 | 0.0889 |
54928 | IMPAD1 | P9T-E | Human | Esophagus | ESCC | 9.75e-05 | 1.51e-01 | 0.1131 |
54928 | IMPAD1 | P10T-E | Human | Esophagus | ESCC | 6.67e-18 | 4.09e-01 | 0.116 |
54928 | IMPAD1 | P11T-E | Human | Esophagus | ESCC | 1.58e-05 | 1.70e-01 | 0.1426 |
54928 | IMPAD1 | P12T-E | Human | Esophagus | ESCC | 9.48e-15 | 1.78e-01 | 0.1122 |
54928 | IMPAD1 | P15T-E | Human | Esophagus | ESCC | 6.42e-12 | 1.36e-01 | 0.1149 |
54928 | IMPAD1 | P16T-E | Human | Esophagus | ESCC | 5.54e-12 | 2.53e-01 | 0.1153 |
54928 | IMPAD1 | P17T-E | Human | Esophagus | ESCC | 9.03e-04 | 2.11e-01 | 0.1278 |
54928 | IMPAD1 | P19T-E | Human | Esophagus | ESCC | 5.04e-04 | 2.18e-01 | 0.1662 |
54928 | IMPAD1 | P20T-E | Human | Esophagus | ESCC | 8.29e-10 | 4.00e-02 | 0.1124 |
54928 | IMPAD1 | P21T-E | Human | Esophagus | ESCC | 1.21e-19 | 4.40e-01 | 0.1617 |
54928 | IMPAD1 | P22T-E | Human | Esophagus | ESCC | 7.05e-12 | 2.33e-02 | 0.1236 |
54928 | IMPAD1 | P23T-E | Human | Esophagus | ESCC | 1.51e-12 | 3.91e-01 | 0.108 |
54928 | IMPAD1 | P26T-E | Human | Esophagus | ESCC | 3.74e-19 | 3.15e-01 | 0.1276 |
54928 | IMPAD1 | P27T-E | Human | Esophagus | ESCC | 1.11e-13 | 1.54e-01 | 0.1055 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00920 | Colorectum | AD | Sulfur metabolism | 8/2092 | 10/8465 | 3.78e-04 | 2.82e-03 | 1.80e-03 | 8 |
hsa009201 | Colorectum | AD | Sulfur metabolism | 8/2092 | 10/8465 | 3.78e-04 | 2.82e-03 | 1.80e-03 | 8 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IMPAD1 | SNV | Missense_Mutation | novel | c.881C>A | p.Thr294Lys | p.T294K | Q9NX62 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-S3-AA17-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
IMPAD1 | SNV | Missense_Mutation | c.337N>G | p.Ser113Ala | p.S113A | Q9NX62 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-C5-A7UE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
IMPAD1 | SNV | Missense_Mutation | c.661G>A | p.Asp221Asn | p.D221N | Q9NX62 | protein_coding | tolerated(0.36) | possibly_damaging(0.448) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
IMPAD1 | SNV | Missense_Mutation | c.1070N>A | p.Gly357Glu | p.G357E | Q9NX62 | protein_coding | tolerated_low_confidence(0.24) | benign(0.037) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IMPAD1 | SNV | Missense_Mutation | c.917C>G | p.Ala306Gly | p.A306G | Q9NX62 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
IMPAD1 | SNV | Missense_Mutation | rs763919379 | c.276N>T | p.Glu92Asp | p.E92D | Q9NX62 | protein_coding | tolerated(0.08) | probably_damaging(0.966) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IMPAD1 | SNV | Missense_Mutation | rs773790200 | c.989N>T | p.Gly330Val | p.G330V | Q9NX62 | protein_coding | tolerated(0.35) | benign(0.007) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
IMPAD1 | SNV | Missense_Mutation | c.860N>T | p.Ala287Val | p.A287V | Q9NX62 | protein_coding | deleterious(0.04) | possibly_damaging(0.817) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
IMPAD1 | SNV | Missense_Mutation | c.376N>A | p.Pro126Thr | p.P126T | Q9NX62 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IMPAD1 | SNV | Missense_Mutation | novel | c.743T>C | p.Met248Thr | p.M248T | Q9NX62 | protein_coding | tolerated(0.45) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |